Rapidly progressive interstitial lung disease risk prediction in anti-MDA5 positive dermatomyositis: the CROSS model

BackgroundThe prognosis of anti-melanoma differentiation-associated gene 5 positive dermatomyositis (anti-MDA5+DM) is poor and heterogeneous. Rapidly progressive interstitial lung disease (RP-ILD) is these patients’ leading cause of death. We sought to develop prediction models for RP-ILD risk in anti-MDA5+DM patients.MethodsPatients with anti-MDA5+DM were enrolled in two cohorts: 170 patients from the southern region of Jiangsu province (discovery cohort) and 85 patients from the northern region of Jiangsu province (validation cohort). Cox proportional hazards models were used to identify risk factors of RP-ILD. RP-ILD risk prediction models were developed and validated by testing every independent prognostic risk factor derived from the Cox model.ResultsThere are no significant differences in baseline clinical parameters and prognosis between discovery and validation cohorts. Among all 255 anti-MDA5+DM patients, with a median follow-up of 12 months, the incidence of RP-ILD was 36.86%. Using the discovery cohort, four variables were included in the final risk prediction model for RP-ILD: C-reactive protein (CRP) levels, anti-Ro52 antibody positivity, short disease duration, and male sex. A point scoring system was used to classify anti-MDA5+DM patients into moderate, high, and very high risk of RP-ILD. After one-year follow-up, the incidence of RP-ILD in the very high risk group was 71.3% and 85.71%, significantly higher than those in the high-risk group (35.19%, 41.69%) and moderate-risk group (9.54%, 6.67%) in both cohorts.ConclusionsThe CROSS model is an easy-to-use prediction classification system for RP-ILD risk in anti-MDA5+DM patients. It has great application prospect in disease management

Study on Improving the Air Quality with Emission Enhanced Control Measures in Beijing during a National Parade Event

Research on the enhanced control and emission-reduction measures to improve air quality during major events could provide data theory and scientific support for air-quality improvement during non-activities. Based on the air-quality data published by the China Environmental Monitoring Station and the meteorological elements and weather conditions released by the China Meteorological Administration, this paper explored the characteristics of air-quality evolution in Beijing from 5 August to 18 September 2015 and the weather situation during the Military Parade. The results showed that: (1) Emission-reduction measures implemented for air quality by Beijing and its surrounding area were induced, and we explored the contribution of these measures to pollutants or AQI in the locality. (2) During the 2015 Military Parade, Beijing was in the front or lower part of the high-pressure system. Due to the strong effect of North or Northeast winds, the weather situation was conducive to the diffusion of pollutants. When before or after the implementation, once the atmospheric diffusion was poor, the pollutants would accumulate gradually. Thus, it can be seen that the weather situation had a great impact on air quality. (3) During the implementation, PM2.5, PM10, NO2 and other pollutants decreased significantly, of which the concentration of PM10 decreased the most, from 109 μg·m−3 down to 34 μg·m−3, and the concentration of PM2.5 decreased by 72.73%. According to the changes between before and during the implementation or during and after the implementation, the concentration of PM10 and PM2.5 increased when the implementation of the emission-reduction measures had been finished, indicating that the enhanced control measures made a great contribution to the emission reduction in particles. (4) In addition, the annual average of AQI in the three years is 87.49, and the average value of a normal year was the average value of 2013 and 2014. The average value of the normal year during the military parade is 64.63, which was 70.40% lower than the average value of AQI during the military parade. The goal of reaching the secondary standard of GB-3095-2012 was achieved, and there was still a long way to go from the primary standard. In a few words, in order to achieve the goal of better air quality throughout the year, all parties still needed to coordinate control and make joint efforts

Study on Improving the Air Quality with Emission Enhanced Control Measures in Beijing during a National Parade Event

Research on the enhanced control and emission-reduction measures to improve air quality during major events could provide data theory and scientific support for air-quality improvement during non-activities. Based on the air-quality data published by the China Environmental Monitoring Station and the meteorological elements and weather conditions released by the China Meteorological Administration, this paper explored the characteristics of air-quality evolution in Beijing from 5 August to 18 September 2015 and the weather situation during the Military Parade. The results showed that: (1) Emission-reduction measures implemented for air quality by Beijing and its surrounding area were induced, and we explored the contribution of these measures to pollutants or AQI in the locality. (2) During the 2015 Military Parade, Beijing was in the front or lower part of the high-pressure system. Due to the strong effect of North or Northeast winds, the weather situation was conducive to the diffusion of pollutants. When before or after the implementation, once the atmospheric diffusion was poor, the pollutants would accumulate gradually. Thus, it can be seen that the weather situation had a great impact on air quality. (3) During the implementation, PM2.5, PM10, NO2 and other pollutants decreased significantly, of which the concentration of PM10 decreased the most, from 109 μg·m−3 down to 34 μg·m−3, and the concentration of PM2.5 decreased by 72.73%. According to the changes between before and during the implementation or during and after the implementation, the concentration of PM10 and PM2.5 increased when the implementation of the emission-reduction measures had been finished, indicating that the enhanced control measures made a great contribution to the emission reduction in particles. (4) In addition, the annual average of AQI in the three years is 87.49, and the average value of a normal year was the average value of 2013 and 2014. The average value of the normal year during the military parade is 64.63, which was 70.40% lower than the average value of AQI during the military parade. The goal of reaching the secondary standard of GB-3095-2012 was achieved, and there was still a long way to go from the primary standard. In a few words, in order to achieve the goal of better air quality throughout the year, all parties still needed to coordinate control and make joint efforts