Fabrication and magnetic properties of Sm2Co17 and Sm2Co17/Fe7Co3 magnetic nanowires via AAO templates

AbstractThe Sm2Co17 single-phase and Sm2Co17/Fe7Co3 double-phase nanowire arrays with smaller diameter (around 50nm) have been fabricated into the anodic aluminum oxide (AAO) templates by direct-current electrodeposition. The crystal structure and micrograph of these nanowire arrays were characterized by X-ray diffraction, field-emission scanning electron microscopy and transmission electron microscopy (TEM). It is found that the as-deposited Sm2Co17 nanowires have the amorphous microstructure. The magnetic hysteresis loops obtained by vibrating sample magnetometer (VSM) show that the easily magnetized direction of the Sm2Co17 single-phase and Sm2Co17/Fe7Co3 double-phase nanowire arrays is parallel to the nanowire arrays and the exchange coupling interaction in nanocomposite Sm2Co17/Fe7Co3 is discussed. The study of the Sm2Co17 single-phase and Sm2Co17/Fe7Co3 double-phase nanowires with small diameter may open up new opportunities for the design and control of nanostructures such as the fabrication of magnetic recording devices

Exploratory analysis of gut microbiota differences in childhood asthma with different severity

Objective·To explore the characteristics and differences of gut microbiota in children with different severity of bronchial asthma, and build a prediction model of gut microbiota in severe asthma.Methods·In this study, children aged 5 to 14 diagnosed with asthma in the Department of Respiratory Medicine of Children's Hospital of Fudan University from Sep 1, 2020 to Aug 31, 2022 were selected, and children with severe asthma (SA) according to the Recommendations for Standardized Diagnosis and Management of Bronchial Asthma in Children (2020) were included. Children with mild to moderate asthma (MMA) and healthy children in the same period were matched according to age and gender. Stool samples collected from the three groups were subjected to 16S rRNA gene sequencing and the gut microbiota diversity, structure, and composition were assessed. The area under the receiver operating characteristic (ROC) curve (AUC) was applied to compare the predictive efficacy for SA.Results·Fifty children were enrolled in the SA group, 54 children matched by gender and age were in the MMA group and 39 healthy children were in the healthy control group. The α diversity of gut microbiota significantly decreased in the asthma children (P<0.05), compared with that in the healthy control group. The relative abundance of Treponema was the highest in the SA group, followed by the MMA group and healthy control group (P<0.001). The relative abundance of Lactobacillus in the MMA group and SA group was higher than that in the healthy control group (both P<0.05). The SA group had a higher relative abundance of Prevotella, Lactobacillus, Eubacterium_eligens_group, Treponema, and Fusicatenibacter. The MMA group had a higher relative abundance of Barnesiella, Holdemanella, Romboutsia and Turicibacter. The healthy control group had a higher relative abundance of the uncultured and Muribaculaceae. Among them, the relative abundance of Barnesiella decreased in the SA group, and it was found to have the highest sensitivity and specificity in predicting SA (AUC 0.713, 95%CI 0.604‒0.815).Conclusion·The diversity of gut microbiota in asthma children is lower than that in healthy children, and the composition of gut microbiota differs among childhood asthma with different severity. The abundance of Barnesiella decreases in the SA group significantly, suggesting that analysis of gut microbiota may help in the assessment of childhood asthma with different severity

Intermittent protein restriction before but not after the onset of diabetic kidney disease attenuates disease progression in mice

BackgroundHigh dietary protein intake exacerbates proteinuria in individuals with diabetic kidney disease (DKD). However, studies on the impacts of low protein diet (LPD) on DKD have yielded conflicting results. Furthermore, patient compliance to continuous protein restriction is challenging.ObjectiveThe current study aims to investigate the effects of intermittent protein restriction (IPR) on disease progression of DKD.MethodsDiabetic KK-Ay mice were used in this study. For the IPR treatment, three consecutive days of LPD were followed by four consecutive days of normal protein diet (NPD) within each week. For early intervention, mice received IPR before DKD onset. For late intervention, mice received IPR after DKD onset. In both experiments, age-matched mice fed continuous NPD served as the control group. Kidney morphology, structure and function of mice in different groups were examined.ResultsIntermittent protein restriction before DKD onset ameliorated pathological changes in kidney, including nephromegaly, glomerular hyperfiltration, tubular injuries and proteinuria, without improving glycemic control. Meanwhile, IPR initiated after DKD onset showed no renoprotective effects despite improved glucose homeostasis.ConclusionIntermittent protein restriction before rather than after DKD onset protects kidneys, and the impacts of IPR on the kidneys are independent of glycemic control. IPR shows promise as an effective strategy for managing DKD and improving patient compliance

Tislelizumab in Patients with Previously Treated Advanced Hepatocellular Carcinoma (RATIONALE-208): A Multicenter, Non-Randomized, Open-Label, Phase 2 Trial

Introduction: Tislelizumab (anti-programmed cell death protein 1 antibody) showed preliminary antitumor activity and tolerability in patients with advanced solid tumors, including hepatocellular carcinoma (HCC). This study aimed to assess the efficacy and safety of tislelizumab in patients with previously treated advanced HCC. Methods: The multi-regional phase 2 study, RATIONALE-208, examined single-agent tislelizumab (200 mg intravenously every three weeks) in patients with advanced HCC with Child-Pugh A, Barcelona Clinic Liver Cancer stage B or C, and who had received one or more prior lines of systemic therapy. The primary endpoint was objective response rate (ORR), radiologically confirmed per Response Evaluation Criteria in Solid Tumors version 1.1 by Independent Review Committee. Safety was assessed in patients who received ≥1 dose of tislelizumab. Results: Between April 9, 2018 and February 27, 2019, 249 eligible patients were enrolled and treated. After a median study follow-up of 12.7 months, ORR was 13% (n = 32/249; 95% confidence interval [CI], 9–18), including five complete and 27 partial responses. Number of prior lines of therapy did not impact ORR (one prior line, 13% [95% CI, 8–20]; two or more prior lines, 13% [95% CI, 7–20]). Median duration of response was not reached. Disease control rate was 53% and median overall survival was 13.2 months. Of the 249 total patients, grade ≥3 treatment-related adverse events were reported in 38 (15%) patients; the most common was liver transaminase elevations in 10 (4%) patients. Treatment-related adverse events led to treatment discontinuation in 13 (5%) patients or dose delay in 46 (19%) patients. No deaths were attributed to the treatment per investigator assessment. Conclusion: Tislelizumab demonstrated durable objective responses, regardless of the number of prior lines of therapy, and acceptable tolerability in patients with previously treated advanced HCC

New town - model for a sustainable new town planning and its application in China

Seit dem Beginn des 20. Jahrhunderts ist die Entwicklung Neuer Städte ein sehr wichtiges Element der modernen Städtebautheorie und Städtebaupraxis. Auf der materiellen „Ebene“ haben die Neuen Städte mit der Unterstützung der Öffentlichen Hand eine hohe „Quantität“ der Massenbebauung ermöglicht, sie dient unterschiedlichen Entwicklungszielen auf der Ebene der Kommune, der Region und des Landes, ebenso wie der Behebung der Wohnungsnot, der Entlastung der Metropolen oder der Förderung von Wirtschaftszentren. Die Neue Stadt hat eine besondere natürliche „Qualität“, die regionale, gut eingebundene Lage der Neuen Städte, ihre Einbindung in die natürliche Umwelt und das hohe Niveau ihrer Infrastruktur und ihrer öffentlichen Einrichtungen. Der Bau Neuer Städte erweist sich geschichtlich immer als eines der wichtigsten Mittel zur Stärkung der kommunalen und regionalen Kompetenzkraft; deshalb wurden auch immer dann noch Neue Stadt-Quartiere gebaut, wenn die Wohnungsnot nicht mehr vorhanden war. Die Entwicklung der Neuen Städte ist auch ein ständiger Zeuge der Entwicklung der Städtebautheorien und von diesen im Positiven wie im Negativen ständig beeinflusst. Die Planung ganzer Neuer Städte ist eine der kompliziertesten Aufgaben des Städtebaus - die Realisierung ungeprüfter Innovationen, das schnelle Planungs- und Entwicklungstempo, die aus finanziellen Gründen oft schwach ausgeprägten öffentlichen Einrichtungen oder die Folgen einseitiger Sozialpolitik verstärken die Schwierigkeiten bei der Entwicklung einer Neuen Stadt. Das einseitige Übergewicht quantitativer Maßstäbe erzeugt eine Diskrepanz zwischen Qualität und Quantität. Die Neuen Städte als Aufgabe Das Thema der - so definierten - „Neuen Städte“ ist heute sowohl wegen der Erneuerungsbedürfnisse der „alten“ Neuen Städte, der Entwicklungsbedürfnisse der Neuen Stadt-Quartiere, sowohl in Europa, wie auch in der globalen Neue Stadt-Entwicklung von höchster Aktualität. Als ein Spiegel der modernen Städtebau-Entwicklung ist die Neue Stadt sowohl auf der Ebene der Forschung als auch der Praxis von sehr hoher Bedeutung, jedoch gibt es seit den 1970er Jahren zu dem Thema „Neue Stadt“ kaum noch Forschungsaktivitäten. In China ist die „Neue Stadt“, bereits in der Historie, immer ein wichtiges Element des Stadtentwicklungsmodells gewesen. Die Stadt ist der klar definierte Träger der speziellen Bedeutung: von der Gesellschaftsordnung über die Philosophie bis insbesondere zu der Politik. Die einschneidende Veränderung der chinesischen Kultur am Ende des Kaiserreiches - zu Beginn des 20. Jahrhunderts - führte zu einer Philosophie, welche die „westliche Kultur“ in Bezug auf Funktion und Form aufnimmt, jedoch die chinesische lokale Kultur als Seele - der Stadt - begreift. Diese Art der Trennung - der Stadtauffassung - beeinflusst die Philosophie der chinesischen Stadtentwicklung noch heute. Die 80er Jahre des 20. Jahrhunderts waren der Anfang der Ausbreitung der chinesischen Verstädterung. In diesem rasanten Verstädterungsprozess haben nicht nur die Metropolen, sondern auch die chinesischen Mittel- und Kleinstädte, die Neue Stadt als das wichtigste Instrument der Stadtentwicklung gewählt. Jedoch ist aufgrund des begrenzten Überblickes und des mangelhaften Wissensstandes, insbesondere für eine chinesische Neue Stadt heute, deren Grundlage in materieller sowie immaterieller Hinsicht schwach. Leitgedanken der Planung Neuer Städte Aus der hier dargestellten Forschungsarbeit lassen sich, als erster Teil der Arbeitsergebnisse, folgende Erfahrungen zusammenfassen: - Soziale Stadtgesellschaft: In der Planung einer Neuen Stadt ist nicht die Stadt selbst das wichtigste Entwicklungsziel, sondern vielmehr die Gesellschaft der Neuen Stadt. - Harmonische Humanität: Der eigentliche Zweck einer Neuen Stadt ist die harmonische Humanität, - d.h. die Schaffung eines Gleichgewichts der oft polaren Bedürfnisse der Menschen. - Global-historisches Stadtbild: Das Stadtbild, der Spiegel der immateriellen Qualität einer „Neuen Stadt“, ist deshalb ebenso wichtig wie die materielle Stadt und ihre funktionale Effektivität. Die Identität des Stadtbildes beruht auf einer Synthese von moderner, globaler Weltkultur und historischer, regionaler Kultur. Modell einer nachhaltigen Neue Stadt-Planung Aus diesem ergeben sich die Anforderungen an den Sinn, Inhalt und Ablauf der Planung einer Neuen Stadt sowie an den Hintergrund der Gründungsinitiative, die Gruppe der Initiatoren, den Planungsinhalt, den Arbeitsprozess, allgemeine Grundsätze des Städtebaus und der Planung Neuer Städte. Als Beispiele werden europäische und chinesische Neue Städte vor dem Hintergrund der Ansprüche der Menschen an ihre physische und psychische Umwelt analysiert.Since the beginning of the 20th Century, the development of new towns is a very important element of the modern urban planning theory and the practice of urban development. On a physical level, the new towns have a special “quantity” of large buildings and rich developed areas with support from the public sector. They serve different development objectives at local, regional and national levels, such as solving the housing shortage, the discharge of the metropolis, or the promotion of economic centers. The new city also has special natural born qualities, the location of the new towns, their integration into the natural environment, its high level of infrastructure and new public facilities. Historically, the establishment of new cities always proves to be one of the most important means to strengthen local and regional expertise; therefore nowadays more and more new city blocks are built, even when the housing shortage has no longer existed. The development of new towns is like witnessing the evolution of urban planning theories, from those in both the positive and negative influences. The planning of complete new towns is already one of the most complicated tasks of urban planning - it is believed that the problems are worsened by the realization of untested innovations, the rapid pace of development and planning, financial reasons, weak public facilities, or a one-sided social policy. The unilateral emphasis on the quantity causes discrepancies between quality and quantity. The new towns as a task The topic of the – so called – “new towns” requirements today both concern the renovation needs of the “old” new towns and the development needs of new communities in Europe and the global new urban development, from the most up-to-date. The new town as a mirror of modern urban development is highly meaningful from both a research and a practical level. However the research on the topic "New Town" has been almost complete since the 1970's. In China, the "new town" had historically been an important element of the urban development model. The town is a well-defined carrier having special importance to the social order and particularly in philosophy and politics too. The dramatic change in the Chinese culture at the end of the empire - at the beginning of the 20th Century - has led to a philosophy that accommodates the western culture in both form and functionalities, but the local Chinese culture as a soul – can be seen in the towns. This kind of separation - the town view - influenced the philosophy of the Chinese town development today. The 1980s was the beginning of the spread of Chinese urbanization. In this rapid urbanization process, it was not only the metropolises, but also the Chinese medium and small towns that chose the "new towns" as the most important characteristic of urban development. Nowadays, because of a limited overview and insufficient knowledge, the foundation of Chinese new towns seems to be weak materially and immaterially. Guide principle in planning new towns As the first part of the results of this paper, the following experience is summarized: - Social urban society: To plan a new town, the most important thing is not the town per se, but the society in a new town. - Harmonic Humanity: The real purpose of a New Town is a harmonious humanity – it means a human living environment - that is capable of all material and immaterial needs of all classes and all levels of generation to meet the prospective city inhabitant. - Global historical town: the town, a mirror of the immaterial qualities of a "New Town", is just as important as the physical town and its functional effectiveness. The identity of the cityscape is based on a synthesis of modern, global culture and historical, regional culture. Model of a sustainable new town planning Therefore the basis of a theoretical model for a new city can be determined. Things such as the background to the start-up initiative, the group of initiators, the content of planning, the work process and the general principles of urban design and planning of new towns. As an example, a new Chinese "New Towns" is analyzed with the context of requirements from a Chinese family on their physical and psychological environment

Yoshinothrips Kudo 1985

Yoshinothrips Kudo This genus consists of four species, and a key to these was provided by Mirab-balou et al. (2012). Three of the species are known from China, pasekamui, ponkamui and tianmushanensis (Zhang et al. 2018). Yoshinothrips species usually have the pronotal posteroangular setae much longer than the posteromarginal setae (Fig. 32), and antennal segment III with a simple sense-cone.Published as part of Li, Yajin, Li, Zhengyue & Zhang, Hongrui, 2019, Trichromothrips genus-group (Thysanoptera, Thripidae) from China, with descriptions of three new species and ten new records, pp. 79-92 in Zootaxa 4544 (1) on page 85, DOI: 10.11646/zootaxa.4544.1.3, http://zenodo.org/record/261814

Trichromothrips genus-group (Thysanoptera, Thripidae) from China, with descriptions of three new species and ten new records

Li, Yajin, Li, Zhengyue, Zhang, Hongrui (2019): Trichromothrips genus-group (Thysanoptera, Thripidae) from China, with descriptions of three new species and ten new records. Zootaxa 4544 (1): 79-92, DOI: https://doi.org/10.11646/zootaxa.4544.1.