Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury

Kidney injury molecule-1 (KIM-1) is a specific histological biomarker for diagnosing early tubular injury on renal biopsies. In this study, KIM-1 expression was quantitated in renal transplant biopsies by immunohistochemistry and correlated with renal function. None of the 25 protocol biopsies showed detectable tubular injury on histologic examination, yet 28% had focal positive KIM-1 expression. Proximal tubule KIM-1 expression was present in all biopsies from patients with histological changes showing acute tubular damage and deterioration of kidney function. In this group, higher KIM-1 staining predicted a better outcome with improved blood urea nitrogen (BUN), serum creatinine, and estimated glomerular filtration rate (eGFR) over an ensuing 18 months. KIM-1 was expressed focally in affected tubules in 92% of kidney biopsies from patients with acute cellular rejection. By contrast, there was little positive staining for Ki-67, a cell proliferation marker, in any of the groups. KIM-1 expression significantly correlated with serum creatinine and BUN, and inversely with the eGFR on the biopsy day. Our study shows that KIM-1 staining sensitively and specifically identified proximal tubular injury and correlated with the degree of renal dysfunction. KIM-1 expression is more sensitive than histology for detecting early tubular injury, and its level of expression in transplant biopsies may indicate the potential for recovery of kidney function

Discussion on the paper 'Analyzing short time series data from periodically fluctuating rodent populations by threshold models: a nearest block bootstrap approach'

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Preparation of polarization entangled mixed states of two photons

We propose a scheme for preparing arbitrary two photons polarization entangled mixed states via controlled location decoherence. The scheme uses only linear optical devices and single-mode optical fibers, and may be feasible in experiment within current optical technology.Comment: 3 pages, 5 figs. The article has been rewritten. Discussion about experiment are added. To appear in Phys. Rev.

Frozen thermal fluctuations in adsorbate-induced step restructuring

Ammonia adsorbed on a Pt(443) surface causes meandering of the initially straight edges at 300 K. Based on density-functional theory calculations and on kinetic Monte Carlo simulations it is shown that the meandering is not an equilibrium structure stabilized by the larger adsorption energy of ammonia at step and kink sites. Rather the meandering has to be interpreted as a frozen thermal fluctuation caused by ammonia which strongly reduces the stiffness of the step edges at intermediate ammonia coverages

Relaxation kinetics in two-dimensional structures

We have studied the approach to equilibrium of islands and pores in two dimensions. The two-regime scenario observed when islands evolve according to a set of particular rules, namely relaxation by steps at low temperature and smooth at high temperature, is generalized to a wide class of kinetic models and the two kinds of structures. Scaling laws for equilibration times are analytically derived and confirmed by kinetic Monte Carlo simulations.Comment: 6 pages, 7 figures, 1 tabl

Entanglement in the One-dimensional Kondo Necklace Model

We discuss the thermal and magnetic entanglement in the one-dimensional Kondo necklace model. Firstly, we show how the entanglement naturally present at zero temperature is distributed among pairs of spins according to the strength of the two couplings of the chain, namely, the Kondo exchange interaction and the hopping energy. The effect of the temperature and the presence of an external magnetic field is then investigated, being discussed the adjustment of these variables in order to control the entanglement available in the system. In particular, it is indicated the existence of a critical magnetic field above which the entanglement undergoes a sharp variation, leading the ground state to a completely unentangled phase.Comment: 8 pages, 13 EPS figures. v2: four references adde

Entanglement Sudden Death in Band Gaps

Using the pseudomode method, we evaluate exactly time-dependent entanglement for two independent qubits, each coupled to a non-Markovian structured environment. Our results suggest a possible way to control entanglement sudden death by modifying the qubit-pseudomode detuning and the spectrum of the reservoirs. Particularly, in environments structured by a model of a density-of-states gap which has two poles, entanglement trapping and prevention of entanglement sudden death occur in the weak-coupling regime

Quantum teleportation of light beams

We experimentally demonstrate quantum teleportation for continuous variables using squeezed-state entanglement. The teleportation fidelity for a real experimental system is calculated explicitly, including relevant imperfection factors such as propagation losses, detection inefficiencies and phase fluctuations. The inferred fidelity for input coherent states is F = 0.61 +- 0.02, which when corrected for the efficiency of detection by the output observer, gives a fidelity of 0.62. By contrast, the projected result based on the independently measured entanglement and efficiencies is 0.69. The teleportation protocol is explained in detail, including a discussion of discrepancy between experiment and theory, as well as of the limitations of the current apparatus.Comment: 17 pages, 19 figures, submitted to PR

Optimal discrimination of mixed quantum states involving inconclusive results

We propose a generalized discrimination scheme for mixed quantum states. In the present scenario we allow for certain fixed fraction of inconclusive results and we maximize the success rate of the quantum-state discrimination. This protocol interpolates between the Ivanovic-Dieks-Peres scheme and the Helstrom one. We formulate the extremal equations for the optimal positive operator valued measure describing the discrimination device and establish a criterion for its optimality. We also devise a numerical method for efficient solving of these extremal equations.Comment: 5 pages, 1 figur

Modular Equations and Distortion Functions

Modular equations occur in number theory, but it is less known that such equations also occur in the study of deformation properties of quasiconformal mappings. The authors study two important plane quasiconformal distortion functions, obtaining monotonicity and convexity properties, and finding sharp bounds for them. Applications are provided that relate to the quasiconformal Schwarz Lemma and to Schottky's Theorem. These results also yield new bounds for singular values of complete elliptic integrals.Comment: 23 page