Corporate religiosity and individual decision on conducting entrepreneurial activity : The contingent effects of institutional environments in China

Feng Zhang acknowledges the financial support from the Research Project of Ministry of Education of China (Grant No. 18JJD630003) and the Fundamental Research Funds for the Central Universities (Grant No. 63185009 and 63,185,011), and Haina Zhang acknowledges the financial support from Skills Acquisition Award received from the British Academy (award reference: SQ140008). Open Access via Springer Compact Agreement.Peer reviewedPublisher PD

Reconfigurable Intelligent Surfaces for Wireless Communications: Principles, Challenges, and Opportunities

Recently there has been a flurry of research on the use of reconfigurable intelligent surfaces (RIS) in wireless networks to create smart radio environments. In a smart radio environment, surfaces are capable of manipulating the propagation of incident electromagnetic waves in a programmable manner to actively alter the channel realization, which turns the wireless channel into a controllable system block that can be optimized to improve overall system performance. In this article, we provide a tutorial overview of reconfigurable intelligent surfaces (RIS) for wireless communications. We describe the working principles of reconfigurable intelligent surfaces (RIS) and elaborate on different candidate implementations using metasurfaces and reflectarrays. We discuss the channel models suitable for both implementations and examine the feasibility of obtaining accurate channel estimates. Furthermore, we discuss the aspects that differentiate RIS optimization from precoding for traditional MIMO arrays highlighting both the arising challenges and the potential opportunities associated with this emerging technology. Finally, we present numerical results to illustrate the power of an RIS in shaping the key properties of a MIMO channel.Comment: to appear in the IEEE Transactions on Cognitive Communications and Networking (TCCN

Variability of Image Features Computed from Conventional and Respiratory-Gated PET/CT Images of Lung Cancer

AbstractRadiomics is being explored for potential applications in radiation therapy. How various imaging protocols affect quantitative image features is currently a highly active area of research. To assess the variability of image features derived from conventional [three-dimensional (3D)] and respiratory-gated (RG) positron emission tomography (PET)/computed tomography (CT) images of lung cancer patients, image features were computed from 23 lung cancer patients. Both protocols for each patient were acquired during the same imaging session. PET tumor volumes were segmented using an adaptive technique which accounted for background. CT tumor volumes were delineated with a commercial segmentation tool. Using RG PET images, the tumor center of mass motion, length, and rotation were calculated. Fifty-six image features were extracted from all images consisting of shape descriptors, first-order features, and second-order texture features. Overall, 26.6% and 26.2% of total features demonstrated less than 5% difference between 3D and RG protocols for CT and PET, respectively. Between 10 RG phases in PET, 53.4% of features demonstrated percent differences less than 5%. The features with least variability for PET were sphericity, spherical disproportion, entropy (first and second order), sum entropy, information measure of correlation 2, Short Run Emphasis (SRE), Long Run Emphasis (LRE), and Run Percentage (RPC); and those for CT were minimum intensity, mean intensity, Root Mean Square (RMS), Short Run Emphasis (SRE), and RPC. Quantitative analysis using a 3D acquisition versus RG acquisition (to reduce the effects of motion) provided notably different image feature values. This study suggests that the variability between 3D and RG features is mainly due to the impact of respiratory motion

Synthesis and Anti-Inflammatory Activity of 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-Derived NRF2 Activators

This is the first study investigating the nuclear factor (erythroid‐derived 2)‐like 2 (NRF2) activity of compounds containing a new scaffold, tetrahydrobenzo[b]thiophene. Eighteen compounds were synthesised and confirmed their NRF2 activation through NQO1 enzymatic activity and mRNA expression of NQO1 and HO‐1 in Hepa‐1c1c7 cells. The compounds disrupted the interaction between Kelch‐like ECH‐associated protein 1 (KEAP1) and NRF2 via interfering with the KEAP1’s Kelch domain. The compounds exhibited anti‐inflammatory activity in Escherichia coli Lipopolysaccharide (LPS( Ec ))‐stimulated RAW 264.7 cells. The anti‐inflammatory activity of the compounds was associated with their ability to activate NRF2. The compounds reversed the elevated levels of pro‐inflammatory cytokines (IL‐1β, IL‐6, TNF‐α, and IFN‐γ) and inflammatory mediators (PGE2, COX‐2, and NF‐κB). The compounds were metabolically stable in human, rat, and mouse liver microsomes and showed optimum half‐life (T(1/2)) and intrinsic clearance (Cl(int)). The binding mode of the compounds and physicochemical properties were predicted via in silico studies

Intense duskside lower band chorus waves observed by Van Allen Probes: Generation and potential acceleration effect on radiation belt electrons

Abstract Local acceleration driven by whistler mode chorus waves largely accounts for the enhancement of radiation belt relativistic electron fluxes, whose favored region is usually considered to be the plasmatrough with magnetic local time approximately from midnight through dawn to noon. On 2 October 2013, the Van Allen Probes recorded a rarely reported event of intense duskside lower band chorus waves (with power spectral density up to 10-3nT 2/Hz) in the low-latitude region outside of L=5. Such chorus waves are found to be generated by the substorm-injected anisotropic suprathermal electrons and have a potentially strong acceleration effect on the radiation belt energetic electrons. This event study demonstrates the possibility of broader spatial regions with effective electron acceleration by chorus waves than previously expected. For such intense duskside chorus waves, the occurrence probability, the preferential excitation conditions, the time duration, and the accurate contribution to the long-term evolution of radiation belt electron fluxes may need further investigations in future

Discovery of natural nicking endonucleases Nb.BsrDI and Nb.BtsI and engineering of top-strand nicking variants from BsrDI and BtsI

BsrDI and BtsI restriction endonucleases recognize and cleave double-strand DNA at the sequences GCAATG (2/0) and GCAGTG (2/0), respectively. We have purified and partially characterized these two enzymes, and analyzed the genes that encode them. BsrDI and BtsI are unusual in two respects: each cleaves DNA as a heterodimer of one large subunit (B subunit) and one small subunit (A subunit); and, in the absence of their small subunits, the large subunits behave as sequence-specific DNA nicking enzymes and only nick the bottom strand of the sequences at these respective positions: GCAATG (−/0) and GCAGTG (−/0). We refer to the single subunit, the bottom-strand nicking forms as ‘hemidimers’. Amino acid sequence comparisons reveal that BsrDI and BtsI belong to a family of restriction enzymes that possess two catalytic sites: a canonical PD-Xn-EXK and a second non-canonical PD-Xn-E-X12-QR. Interestingly, the other family members, which include BsrI (ACTGG 1/−1) and BsmI/Mva1269I (GAATGC 1/−1) are single polypeptide chains, i.e. monomers, rather than heterodimers. In BsrDI and BtsI, the two catalytic sites are found in two separate subunits. Site-directed mutagenesis confirmed that the canonical catalytic site located at the N-terminus of the large subunit is responsible for the bottom-strand cleavage, whereas the non-canonical catalytic site located in the small subunit is responsible for hydrolysis of the top strand. Top-strand specific nicking variants, Nt.BsrDI and Nt.BtsI, were successfully engineered by combining the catalytic-deficient B subunit with wild-type A subunit

Chiral patterns arising from electrostatic growth models

Recently, unusual and strikingly beautiful seahorse-like growth patterns have been observed under conditions of quasi-two-dimensional growth. These `S'-shaped patterns strongly break two-dimensional inversion symmetry; however such broken symmetry occurs only at the level of overall morphology, as the clusters are formed from achiral molecules with an achiral unit cell. Here we describe a mechanism which gives rise to chiral growth morphologies without invoking microscopic chirality. This mechanism involves trapped electrostatic charge on the growing cluster, and the enhancement of growth in regions of large electric field. We illustrate the mechanism with a tree growth model, with a continuum model for the motion of the one-dimensional boundary, and with microscopic Monte Carlo simulations. Our most dramatic results are found using the continuum model, which strongly exhibits spontaneous chiral symmetry breaking, and in particular finned `S' shapes like those seen in the experiments.Comment: RevTeX, 12 pages, 9 figure

Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus

RecG is a DNA translocase encoded by most species of bacteria. The Escherichia coli protein targets branched DNA substrates and drives the unwinding and rewinding of DNA strands. Its ability to remodel replication forks and to genetically interact with PriA protein have led to the idea that it plays an important role in securing faithful genome duplication. Here we report that RecG co-localises with sites of DNA replication and identify conserved arginine and tryptophan residues near its C-terminus that are needed for this localisation. We establish that the extreme C-terminus, which is not resolved in the crystal structure, is vital for DNA unwinding but not for DNA binding. Substituting an alanine for a highly conserved tyrosine near the very end results in a substantial reduction in the ability to unwind replication fork and Holliday junction structures but has no effect on substrate affinity. Deleting or substituting the terminal alanine causes an even greater reduction in unwinding activity, which is somewhat surprising as this residue is not uniformly present in closely related RecG proteins. More significantly, the extreme C-terminal mutations have little effect on localisation. Mutations that do prevent localisation result in only a slight reduction in the capacity for DNA repair. © 2014 The Author(s)

Generation and Characterization of Magnetized Electron Beam From a DC High Voltage Photogun for Electron Beam Cooling Application

One of the most challenging requirements for the proposed Electron–Ion Collider is the strong cooling of the proton beam, which is key to achieving the collider’s desired luminosity of order 1033–1034cm−2s−1. Magnetized bunched-beam electron cooling could be a means to achieve the required high luminosity, where strong cooling is accomplished inside a cooling solenoid where the ions co-propagate with an electron beam generated from a source immersed in a magnetic field. To increase the cooling efficiency, a bunched electron beam with high bunch charge and high repetition rate is required. This work describes the production and characterization of magnetized electron beam using a compact 300 kV DC high voltage photogun and bi-alkali antimonide photocathode. Beam magnetization was studied using a diagnostic beamline that includes viewer screens for measuring the shearing angle of the electron beamlet passing through a narrow upstream slit. Simulations and corresponding measurements of beam magnetization are presented as a function of laser spot size and magnetic field strength. Correlated beam emittance with magnetic field (0–0.15T) at the photocathode was measured for various laser spot sizes. Measurements of photocathode lifetime were carried out at different magnetized electron beam currents up to 28 mA, and bunch charge up to 0.7 nC (not simultaneously)