Features of the Three Dimensional Structure in the Pacific Sub-surface Layer in Summer

The anomaly of the summer sea temperature is analyzed by a spatial-temporal synthetically rotated orthogonal function (REOF) at three different depths (0 m, 40 m, and 120 m) over the area 110°E~100°W and 30°S~60°N. The spatial-temporal distribution shows that the “signal” of annual anomaly is stronger in the sub-surface layer than the surface layer, and it is stronger in the eastern equatorial Pacific than in the western area. The spatial structure of the sea temperature anomaly at different layers is related to both the ocean current and the interaction of ocean and atmosphere. The temporal changing trend of the sub-surface sea temperature in different areas shows that the annual mean sea temperature increases and the annual variability evidently increases from the 1980s, and these keep the same trend with the increasing El Nino phenomenon very well

Improved performance of diatomite-based dental nanocomposite ceramics using layer-by-layer assembly

To fabricate high-strength diatomite-based ceramics for dental applications, the layer-by-layer technique was used to coat diatomite particles with cationic [poly(allylamine hydrochloride)] and anionic [poly(sodium 4-styrenesulfonate)] polymers to improve the dispersion and adsorption of positively charged nano-ZrO2 (zirconia) as a reinforcing agent. The modified diatomite particles had reduced particle size, narrower size distribution, and were well dispersed, with good adsorption of nano-ZrO2. To determine the optimum addition levels for nano-ZrO2, ceramics containing 0, 20, 25, 30, and 35 wt% nano-ZrO2 were sintered and characterized by the three-point bending test and microhardness test. In addition to scanning electron microscopy, propagation phase-contrast synchrotron X-ray microtomography was used to examine the internal structure of the ceramics. The addition of 30 wt% nano-ZrO2 resulted in the highest flexural strength and fracture toughness with reduced porosity. Shear bond strength between the core and veneer of our diatomite ceramics and the most widely used dental ceramics were compared; the shear bond strength value for the diatomite-based ceramics was found to be significantly higher than for other groups (P < 0.05). Our results show that diatomite-based nanocomposite ceramics are good potential candidates for ceramic-based dental materials

Case report: A case study on the treatment using icaritin soft capsules in combination with lenvatinib achieving impressive PR and stage reduction in unresectable locally progressive pancreatic cancer and a literature review

Background: Pancreatic cancer is one of the most deadly malignancies in the world. It is characterized by rapid progression and a very poor prognosis. The five-year survival rate of pancreatic cancer in China is only 7.2%, which is the lowest among all cancers and the use of combined paclitaxel albumin, capecitabine, and digital has been the clinical standard treatment for advanced pancreatic cancer since 1997. Also, the application of multidrug combinations is often limited by the toxicity of chemotherapy. Therefore, there is an urgent need for a more appropriate and less toxic treatment modality for pancreatic cancer.Case presentation: The patient was a 79-year-old woman, admitted to the hospital with a diagnosis of unresectable locally advanced pancreatic cancer (T3N0M0, stage IIA), with its imaging showing overgrowth of SMV involvement and unresectable reconstruction of the posterior vein after evaluation. As the patient refused chemotherapy, lenvatinib (8 mg/time, qd) and icaritin soft capsules (three tablets/time, bid) were recommended according to our past experience and a few clinical research cases. The tumor lesion was greatly reduced by 57.5% after the treatment, and the extent of vascular involvement also decreased. The aforementioned medication resulted in a significant downstaging of the patient’s tumor.Conclusion: Better results were achieved in the treatment with icaritin soft capsules and lenvatinib in this case. Because of its less toxic effect on the liver and kidney and bone marrow suppression, it was suitable to combine icaritin soft capsules with targeted drugs for treating intermediate and advanced malignancies, which brings hope to patients who cannot or refuse to take chemotherapy

Numerical Simulation of Near-Surface Wind during a Severe Wind Event in a Complex Terrain by Multisource Data Assimilation and Dynamic Downscaling

Accurate forecast and simulation of near-surface wind is a great challenge for numerical weather prediction models due to the significant transient and intermittent nature of near-surface wind. Based on the analyses of the impact of assimilating in situ and Advanced Tiros Operational Vertical Sounder (ATOVS) satellite radiance data on the simulation of near-surface wind during a severe wind event, using the new generation mesoscale Weather Research and Forecasting (WRF) model and its three-dimensional variational (3DVAR) data assimilation system, the dynamic downscaling of near-surface wind is further investigated by coupling the microscale California Meteorological (CALMET) model with the WRF and its 3DVAR system. Results indicate that assimilating in situ and ATOVS radiance observations strengthens the airflow across the Alataw valley and triggers the downward transport of momentum from the upper atmosphere in the downstream area of the valley in the initial conditions, thus improving near-surface wind simulations. Further investigations indicate that the CALMET model provides more refined microtopographic structures than the WRF model in the vicinity of the wind towers. Although using the CALMET model achieves the best simulation of near-surface wind through dynamic downscaling of the output from the WRF and its 3DVAR assimilation, the simulation improvements of near-surface wind speed are mainly within 1 m s−1. Specifically, the mean improvement proportions of near-surface wind speed are 64.8% for the whole simulation period, 58.7% for the severe wind period, 68.3% for the severe wind decay period, and 75.4% for the weak wind period. The observed near-surface wind directions in the weak wind conditions are better simulated in the coupled model with CALMET downscaling than in the WRF and its 3DVAR system. It is concluded that the simulation improvements of CALMET downscaling are distinct when near-surface winds are weak, and the downscaling effects are mainly manifested in the simulation of near-surface wind directions

Land Use/Cover Change and Its Relationship with Regional Development in Xixian New Area, China

There is a close relationship between land use/cover change and regional development in new urban areas. In this paper, based on the land-use data before (2010, 2013) and after (2015, 2018) the establishment of Xixian New Area and the economic development data of the corresponding period, with the help of indexes such as the land use transfer matrix, relative change rate/net change rate and the composite index of land use degree, the temporal and spatial differences of land-use change and land use degree in the ten years before and after the establishment of Xixian New Area were analyzed, and the driving factors of land-use change and their relationship with the level of social and economic development were discussed. The results indicate that cultivated land and construction land are the main land-use types in Xixian New Area in the whole studying period. From 2010 to 2018, the area of cultivated land and forest land in the region decreased over time, but the construction land area continuously increased dramatically (increased by 36.5% from 2010 to 2018) and the land-use change corresponds basically to the construction and development process of the New Area. In the spatial transfer of land use, the transformation of cultivated land to construction land was the most evident, and the urbanization construction in the New Area occupied the most cultivated land. The composite index of land use degree in the New Area was generally high and increased with time. Geographical location and policy guidance are the main reasons for the spatial difference of land use degree. The land use benefits in the New Area increased significantly, and the land use degree was positively correlated with the level of regional, social and economic development. The main driving factor of land-use change was human activities guided by policy

Research on Hydroecology Management from the Perspective of Philosophy

To be nature-friendly is to do good to human beings themselves. Ultimately, the relation between human beings and water is being water-friendly. From the perspective of philosophy, this paper conducts indepth analysis and research on the Dujiang Weir Irrigation System, the typical case among water conservancy projects in ancient times, follows the philosophy and scientificity of Taiji Diagram in water control in ancient times, respects the rule of water itself and reduces the philosophy of Taiji Diagram into “one divides into two, unity of opposites, extremes meet, dynamic equilibrium”. Meanwhile, it proposes that “those who are good at managing and utilizing water are kind to water”. They are good at learning about water, comprehending water, mastering the essence of water, the features of water, the moving rule of water; good at utilizing water in a scientific way, control water in a unified way and taking water in a planned way; good at controlling water separately and utilizing water in a unified way; good at blocking water and releasing water; good at resisting water, diverting water and controlling water; good at protecting water, conserving water and maintaining water; good at coordinating the relation between human and water, integrating human and water and codeveloping human and water. With the intention of loving nature and water, people are kind to water, the source of life, from the philosophy of China’s traditional science culture, in combination with modern water conservancy experience and methods. Human beings and water are symbiotic as people need to fight against flood and draught and strike a balance among the dependence on water, the utilization of water and the control of water. Those who are kind to water deem water as family members, friends and live by water, enjoy harmonious relation and integration with water and co-develop with water, thereby living long and prosper in an endless succession. In this way, human beings can better grasp the lifeline of ecology, improve ecological environment and achieve sustainable development

Potential Role of Superoxide Dismutase 3 (SOD3) in Resistance to Influenza A Virus Infection

Influenza A virus infection induces the production of excessive reactive oxygen species (ROS). Overproduction of ROS can overwhelm the antioxidant defense system, leading to increasing intensive oxidative stress. However, antioxidant defense against oxidative damage induced by influenza A virus infection, and in particular the significance of the SOD3 response in the pathogenesis of influenza virus infection, has not been well characterized. Here, we investigated the potential role of SOD3 in resistance to influenza A virus infection. In this study, SOD3, as an important antioxidant enzyme, was shown to be highly elevated in A549 cells following influenza A virus infection. Furthermore, inhibition of SOD3 impacted viral replication and virulence. We found that SOD3 disrupts IAV replication by impairing the synthesis of vRNA, whereas it did not affect viral ribonucleoprotein nuclear export. In addition, overexpression of SOD3 greatly reduced the levels of ROS caused by influenza A virus infection, regulated the inflammatory response to virus infection by inhibiting the phosphorylation of p65 of the NF-κB signaling pathway, and inhibited virus-induced apoptosis to a certain extent. Taken together, these findings indicate that SOD3 is actively involved in influenza A virus replication. Pharmacological modulation or targeting of SOD3 may pave the way for a novel therapeutic approach to combating influenza A virus infection