445 research outputs found
Di-μ-chlorido-bisÂ{aquaÂchlorido[3-ethyl-4-phenyl-5-(2-pyridÂyl)-4H-1,2,4-triazole-κ2 N 1,N 5]manganese(II)}
In the centrosymmetric dinuclear title compound, [Mn2Cl4(C15H14N4)2(H2O)2], the MnII atom is coordinated by an N,N′-bidentate ligand, a water molÂecule, a terminal chloride ion and two bridging chloride ions in a distorted MnN2OCl3 octaÂhedral geometry. The Mn⋯Mn separation is 3.6563 (9) Å. In the crystal structure, O—H⋯N and O—H⋯Cl hydrogen bonds help to establish the packing
Research on the performance and application of low traffic hardened lime-fly ash pavement materials in rural areas
By means of curing agent hardening technology applied for lime-fly ash road surface, the performance of unconfined compressive strength, water stability and freezing stability of hardened fly ash mixture has been tested, and the feasibility of the technology has been verified. At the same time, combined with the indoor test results, the test road has been paved which achieved good results, and the construction technology is simple, economical and reasonable, so it has a good value of popularization and application
Advances of two-stage riser catalytic cracking of heavy oil for maximizing propylene yield (TMP) process
Three novel α-L-iduronidase mutations in 10 unrelated Chinese mucopolysaccharidosis type I families
Mucopolysaccharidosis type I (MPS I) arises from a deficiency in the α-L-iduronidase (IDUA) enzyme. Although the clinical spectrum in MPS I patients is continuous, it was possible to recognize 3 phenotypes reflecting the severity of symptoms, viz., the Hurler, Scheie and Hurler/Scheie syndromes. In this study, 10 unrelated Chinese MPS I families (nine Hurler and one Hurler/Scheie) were investigated, and 16 mutant alleles were identified. Three novel mutations in IDUA genes, one missense p.R363H (c.1088G > A) and two splice-site mutations (c.1190-1G > A and c.792+1G > T), were found. Notably, 45% (nine out of 20) and 30% (six out of 20) of the mutant alleles in the 10 families studied were c.1190-1G > A and c.792+1G > T, respectively. The novel missense mutation p.R363H was transiently expressed in CHO cells, and showed retention of 2.3% IDUA activity. Neither p.W402X nor p.Q70X associated with the Hurler phenotype, or even p.R89Q associated with the Scheie phenotype, was found in this group. Finally, it was noted that the Chinese MPS I patients proved to be characterized with a unique set of IDUA gene mutations, not only entirely different from those encountered among Europeans and Americans, but also apparently not even the same as those found in other Asian countries
Neural-Hidden-CRF: A Robust Weakly-Supervised Sequence Labeler
We propose a neuralized undirected graphical model called Neural-Hidden-CRF
to solve the weakly-supervised sequence labeling problem. Under the umbrella of
probabilistic undirected graph theory, the proposed Neural-Hidden-CRF embedded
with a hidden CRF layer models the variables of word sequence, latent ground
truth sequence, and weak label sequence with the global perspective that
undirected graphical models particularly enjoy. In Neural-Hidden-CRF, we can
capitalize on the powerful language model BERT or other deep models to provide
rich contextual semantic knowledge to the latent ground truth sequence, and use
the hidden CRF layer to capture the internal label dependencies.
Neural-Hidden-CRF is conceptually simple and empirically powerful. It obtains
new state-of-the-art results on one crowdsourcing benchmark and three
weak-supervision benchmarks, including outperforming the recent advanced model
CHMM by 2.80 F1 points and 2.23 F1 points in average generalization and
inference performance, respectively.Comment: 13 pages, 4 figures, accepted by SIGKDD-202
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