Very Low Frequency Propagation Characteristics Analysis in Coal Mines

Electromagnetic wave penetration coal-rock communication is a significant part for the smart mine communication technology, there are great challenges for electromagnetic wave is rapidly attenuated by factors such as geology and coal seam structure. In order to provide a theory basis for wireless communication technology development in coal rock, based on the Maxwell's equations, this paper establishes a physical model of wireless communication under the conditions of coal seam. To characterize the performance of the electromagnetic wave propagation, we use the Maxwell's equations to derive the exact expression of attenuation coefficient. Also, the parameters of coal and other factors affecting the electromagnetic wave propagation are analyzed and discussed. To further obtain more insights, the attenuation coefficient and skin depth of the very low-frequency (VLF) electromagnetic wave in coal medium with different degrees of metamorphism are studied, as well as the influence of resistivity. This provides scientific theoretical support for the application of VLF communication in coal mines. Finally, our theoretical analyses are verified by computer simulation, and the simulated numerical results show that: 1) The range of frequency of electromagnetic wave suitable for coal medium propagation is 3~3KHz (VLF); 2) The order of the electromagnetic waves attenuation coefficient in coal with different degrees of metamorphism is: anthracite> lignite > fat coal > coking coal > lean coal, and the order of skin depth is: lean coal > coking coal > fat coal> lignite > anthracite; 3) The resistivity of coal has little effect on the attenuation of electromagnetic wave when VLF is used for communication

Research on Traffic Signal Timing Method Based on Ant Colony Algorithm and Fuzzy Control Theory

The number of private cars has a blowout growth with the development of economics, which leads to the existing limited traffic resources cannot meet the normal traffic demand. The emergence of intelligent traffic has improved this phenomenon. Using intelligent traffic technology to conduct intersection vehicles can alleviate the congestion effectively. Traffic signal timing method plays an important role in intelligent traffic research. An independent intersection dynamic timing method combined with fuzzy control theory and improved ant colony algorithm is proposed in this paper. According to the characteristics of traffic flow distribution, the timing period is obtained with the improved webster algorithm. Through the optimal solution obtained by ant colony algorithm and the added delay of traffic signal calculated by fuzzy control method, the dynamic timing period of the traffic signal is obtained. The validity of the proposed method is proved by comparing with the original time period and the traditional algorithm

Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis

© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Xu, X., Li, G., Li, C., Zhang, J., Wang, Q., Simmons, D. K., Chen, X., Wijesena, N., Zhu, W., Wang, Z., Wang, Z., Ju, B., Ci, W., Lu, X., Yu, D., Wang, Q., Aluru, N., Oliveri, P., Zhang, Y. E., Martindale, M. Q., & Liu, J. Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis. National Science Review, 6(5), (2019):993-1003, doi:10.1093/nsr/nwz064.Major evolutionary transitions are enigmas, and the most notable enigma is between invertebrates and vertebrates, with numerous spectacular innovations. To search for the molecular connections involved, we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across metazoans. We focused on gametes and early embryos, where the methylomes are known to evolve divergently between fish and mammals. Here, we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects, but clearly presents in deuterostomes such as echinoderms and invertebrate chordates, and then becomes more evident in vertebrates. Functional association analysis suggests that DNA methylation reprogramming is associated with development, reproduction and adaptive immunity for vertebrates, but not for invertebrates. Interestingly, the single HOX cluster of invertebrates maintains unmethylated status in all stages examined. In contrast, the multiple HOX clusters show dramatic dynamics of DNA methylation during vertebrate embryogenesis. Notably, the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in mammals. Our study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution, especially after the evolutionary transitions from invertebrates to vertebrates, and then to mammals.This work was supported by the National Key Research and Development Program of China (2018YFC1003303), the Strategic Priority Research Program of the CAS (XDB13040200), the National Natural Science Foundation of China (91519306, 31425015), the Youth Innovation Promotion Association of the CAS and the Key Research Program of Frontier Sciences, CAS (QYZDY-SSW-SMC016)

TNFAIP1 contributes to the neurotoxicity induced by Aβ25–35 in Neuro2a cells

Background: Amyloid-beta (Aβ) accumulation is a hallmark of Alzheimer’s disease (AD) that can lead to neuronal dysfunction and apoptosis. Tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) is an apoptotic protein that was robustly induced in the transgenic C. elegans AD brains. However, the roles of TNFAIP1 in AD have not been investigated. Results: We found TNFAIP1 protein and mRNA levels were dramatically elevated in primary mouse cortical neurons and Neuro2a (N2a) cells exposed to Aβ25–35. Knockdown and overexpression of TNFAIP1 significantly attenuated and exacerbated Aβ25–35-induced neurotoxicity in N2a cells, respectively. Further studies showed that TNFAIP1 knockdown significantly blocked Aβ25–35-induced cleaved caspase 3, whereas TNFAIP1 overexpression enhanced Aβ25–35-induced cleaved caspase 3, suggesting that TNFAIP1 plays an important role in Aβ25–35-induced neuronal apoptosis. Moreover, we observed that TNFAIP1 was capable of inhibiting the levels of phosphorylated Akt and CREB, and also anti-apoptotic protein Bcl-2. TNFAIP1 overexpression enhanced the inhibitory effect of Aβ25–35 on the levels of p-CREB and Bcl-2, while TNFAIP1 knockdown reversed Aβ25–35-induced attenuation in the levels of p-CREB and Bcl-2. Conclusion: These results suggested that TNFAIP1 contributes to Aβ25–35-induced neurotoxicity by attenuating Akt/CREB signaling pathway, and Bcl-2 expression

Strength Characteristics of Biochar-Amended Clay Covered Soil Mixed with Methane-Oxidizing Bacteria

Adding biochar to soil can improve the soil’s physical–chemical properties, microscopic pore structure, and bacterial habitat. This affects the soil’s strength characteristics and the oxidization of methane. Using a Humboldt pneumatic direct shear instrument, this study investigated the effect of the amount of biochar in the soil, the soil’s methane-oxidizing bacteria, aeration time, and carbon content on the strength characteristics of a biochar-amended clay. The results show that when the biochar content is low, the soil’s stress–strain curve shows a strain hardening state as the strain increases. When the biochar content is greater than 10%, the methane-oxidizing bacteria increase as the shear strain increases. The stress–strain curves of the biochar–clay mixture all showed a softened state. Under the same biochar content, the soil’s stress–strain curves show strain softening as the methane filling time increases. However, with an increase in the amount of biochar, cohesion gradually increased and the internal friction angle did not change significantly. A scanning electron microscope (SEM) image of the biochar–clay mixture with methane oxidizing bacteria revealed the influence of the evolution law of the samples’ micropore structure on the soil’s stress–strain curve and strength properties