Effect of Ultra-high Pressure Treatment on the Chemical Properties, Colour and Sensory Quality of Young Red Wine

The effects of ultra-high pressure (UHP) treatment on the chemical properties, colour and sensory qualityof young red wine were studied. UHP did not significantly affect the alcohol content, and the methanolcontent was higher than that of the control, with the latter first increasing and then decreasing with theincrease in the pressure or period of treatment. The glycerol content was also markedly changed by UHP,although without a regular pattern. The pH value was not markedly changed by the treatments, and thecontents of total acids and volatile acids were scarcely affected. The fructose and glucose contents wereclearly changed according to the different treatment conditions. The tartaric acid, citric acid and lacticacid levels showed evident changes, whereas the malic acid level was not changed by UHP treatment. Thetrend of these changes was similar to what occurs during natural ageing. As the pressure of the treatmentwas increased to 200 MPa, the chroma value increased, followed by a decline upon higher pressuretreatments. The hue of the wine was significantly changed by treatment at different pressures, reachingthe highest value after treatment at 400 MPa and then decreasing with increasing pressure. The chromaand hue values of the wine were changed significantly according to the duration of the UHP. After UHP, theappearance, aroma and taste of the wine was improved, with the score for appearance obviously increased.When the wine was treated at 500 MPa for 30 min, its sensory quality received the highest score

Lymphocyte apoptosis, macrophage function and disease activity in systemic lupus erythematosus

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The Effects of Ultra-high Pressure Treatment on the Phenolic Composition of Red Wine

Wine is usually aged in oak barrels. In this study, young red wines were treated with ultra-high pressure(UHP) to stimulate the ageing process. Changes in phenolic acids, flavan-3-ols and proanthocyanidinswere determined by reverse-phase high pressure liquid chromatography (RP-HPLC). The concentrationof phenolic acids increased, while the levels of flavan-3-ols decreased. The content and structure ofproanthocyanidins also changed and the tendency was similar to that of natural ageing

Endothelial Cell Cortactin Phosphorylation by Src Contributes to Polymorphonuclear Leukocyte Transmigration In Vitro

The underlying mechanisms that regulate leukocyte transendothelial migration through the vascular endothelium remain unclear. Cortactin is a substrate of Src tyrosine kinases and a regulator of cytoskeletal dynamics. Previous studies demonstrated a role for Src phosphorylation of cortactin in clustering of E-selectin and intercellular cell adhesion molecule-1 around adherent leukocytes. In the current study, we used an in vitro flow model to investigate the role of Src-induced cortactin phosphorylation in endothelium during polymorphonuclear leukocyte (PMN) transmigration through human umbilical vein endothelium (HUVEC) monolayers preactivated with tumor necrosis factor-{alpha}. Inhibition of Src in HUVEC using Src kinase inhibitors PP2 and SU6656 reduced PMN transmigration by 45±8% and 36±6%, respectively. Live cell imaging of green fluorescent protein–tagged cortactin in HUVEC revealed redistribution of cortactin in the region surrounding transmigrating PMN. Knockdown of cortactin in HUVEC by small interfering RNA also impaired transmigration to a similar degree, and this phenotype was rescued by reexpression of wild-type cortactin. Analysis of the location of initial arrest and locomotion of PMN adherent to HUVEC demonstrated that inhibition of Src tyrosine kinases or pretreatment with cortactin small interfering RNA reduced PMN transmigration at endothelial cell-to-cell junctions and not adhesion. Tyrosine phosphorylation of cortactin was important for transmigration, because expression of a mutant, in which the tyrosine phosphorylation sites were mutated to phenylalanine (cortactin3F), failed to rescue PMN transmigration. Moreover, expression of cortactin3F alone partially blocked PMN transmigration. These data suggest a model whereby tyrosine phosphorylation of cortactin by Src family kinases regulates PMN transmigratio

Comprehensive experimental study on prevention of land subsidence caused by dewatering in deep foundation pit with hanging waterproof curtain

Land subsidence caused by dewatering of deep foundations pit has currently become the focus of prevention and control of land subsidence in Shanghai. Because of the reliance on deep foundation dewatering pit projects, two comprehensive test sites were established to help prevent land subsidence. Through geological environmental monitoring during dewatering of a deep foundation pit, the analysis of the relation between artesian water level and soil subsidence, some basic features of land subsidence caused by dewatering of deep foundation pits are elucidated. The results provide a scientific basis for prevention and control of land subsidence caused by dewatering in deep foundation pits

Development of "green" construction in Belarus and China

This article discusses the development of the time management information system. The target platform audience is students of Polotsk State University. A conceptual solution based on data processing and transmission technologies is proposed using the following technologies: TypeScript, Angular, Java, Spring, PostgreSQL. It describes the architectural approaches and solutions to solve the problem

Development of "green" construction in Belarus and China

This article discusses the development of the time management information system. The target platform audience is students of Polotsk State University. A conceptual solution based on data processing and transmission technologies is proposed using the following technologies: TypeScript, Angular, Java, Spring, PostgreSQL. It describes the architectural approaches and solutions to solve the problem

Tungsten Disulphide Based All Fiber Q-Switching Cylindrical-Vector Beam Generation

We proposed and demonstrated an all fiber passively Q-switching laser to generate cylindrical-vectorbeam, a two dimensional material,tungsten disulphide (WS2), was adopted as a saturable absorber inside the laser cavity, while a few-mode fiber Bragg grating was used as a transverse mode-selective output coupler. The repetition rate of the Q-switching output pulses can be varied from 80 kHz to 120 kHz with a shortest duration of 958 ns. Attributed to the high damage threshold and polarization insensitivity of the WS2 based saturable absorber, the radially polarized beam and azimuthally polarized beam can be easily generated in the Q-switchingfiber laser