Interaction between electrical storm and left ventricular ejection fraction as predictors of mortality in patients with implantable cardioverter defibrillator: A Chinese cohort study

AimsTo determine the interaction of electrical storm (ES) and impaired left ventircular ejection fraction (LVEF) on the mortality risk of patients with implantable cardioverter defibrillator (ICD).Methods and resultsA total of 554 Chinese ICD recipients from 2010 to 2014 were retrospectively included and the mean follow-up was 58 months. The proportions of dilated cardiomyopathy and the hypertrophic cardiomyopathy were 26.0% (144/554) and 5.6% (31/554), respectively. There were 8 cases with long QT syndrome, 6 with arrhythmogenic right ventricular cardiomyopathy and 2 with Brugada syndrome. Patients with prior MI accounted for 15.5% (86/554) and pre-implantation syncope accounted for 23.3% (129/554). A total of 199 (35.9%) patients had primary prevention indications for ICD therapy. Both ES and impaired LVEF (<40%) were independent predictors for all-cause mortality [hazard ratio (HR) 2.40, 95% CI 1.57–3.68, P < 0.001; HR 1.94, 95% CI 1.30–2.90, P = 0.001, respectively] and cardiovascular mortality (HR 4.63, 95% CI 2.68–7.98, P < 0.001; HR 2.56, 95% CI 1.47–4.44, p = 0.001, respectively). Compared with patients with preserved LVEF (≥40%) and without ES, patients with impaired LVEF and ES had highest all-cause and cardiovascular mortality risks (HR 4.17, 95% CI 2.16–8.06, P < 0.001; HR 11.91, 95% CI 5.55–25.56, P < 0.001, respectively). In patients with impaired LVEF, ES increased the all-cause and cardiovascular mortality risks (HR 1.84, 95% CI 1.00–3.37, P = 0.034; HR 4.86, 95% CI 2.39–9.86, P < 0.001, respectively). In patients with ES, the deleterious effects of impaired LVEF seemed confined to cardiovascular mortality (HR 2.54, 95% CI 1.25–5.14, p = 0.038), and the HR for all-cause mortality was not significant statistically (HR 1.14, 95% CI 0.54–2.38, P = 0.735).ConclusionBoth ES and impaired LVEF are independent predictors of mortality risk in this Chinese cohort of ICD recipients. The interaction of ES and impaired LVEF in patients significantly amplifies the deleterious effects of each other as distinct disease

Asymptotic Behaviors of the Eigenvalues of Schrödinger Operator with Critical Potential

We study the asymptotic behaviors of the discrete eigenvalue of Schrödinger operator P(λ)=P0+λV with P0=-Δ+qθ/r2. We obtain the leading terms of discrete eigenvalues of P(λ) when the eigenvalues tend to 0. In particular, we obtain the asymptotic behaviors of eigenvalues when (P0−α)−1 has singularity at α=0

Development of Manipulator Digital Twin Experimental Platform Based on RCP

From the perspective of teaching and researching, we developed a manipulator digital twin experiment platform (named the remote experience platform, REP) based on a rapid control prototype (RCP). The platform consisted of a controlled target, a real-time controller, rapid prototype configuration software, and supervisory control software. The controlled target was a 6-DOF manipulator, divided into a physical entity and its digital twin. The 3D model and mathematical model of the manipulator were constructed as an experimental entity in a digital space. The whole system provided flexible and intuitive experimental scenes without the restraints of time and place. Based on RCP technology, students can design various complex control strategies using simulation tools such as Matlab/Simulink, then convert the graphical model into executable code to be performed in target hardware. The framework and development methods of the proposed system are elaborated in this paper. An example is demonstrated, including invocation of algorithms, one-click code generation and compilation, real-time verification and online parameter adjustment, and more. The feasibility and practicability of the system are verified through the PID control experiment of the manipulator