Choice of dual antiplatelet therapy in patients with acute coronary syndrome after percutaneous coronary intervention

The article presents modern approaches to choosing a P2Y12 inhibitor as part of combined antithrombotic therapy in patients with acute coronary syndrome, depending on the indications for interventional treatment and the presence of comorbidities such as atrial fibrillation and diabetes

VESSEL WALL STIFFNESS IN ARTERIAL HYPERTENSION AND OPPORTUNITIES FOR ITS MODULATION

Arterial hypertension (AH) is a serious medical and social problem due to its complications leading to disability. Recently, there is a lot of attention paid to markers evaluation for cardiovascular pathology — endothelial dysfunction,  arteries  elasticity decline,  increased  pulse  wave velocity (vascular  wall stiffness)  and  studying  of  an  influence  of  various antihypertension  treatments. Current  article  focuses  on  the  modern influences on remodeling of vessel wall in AH and opportunities  of its pharmacological   correction   with  angiotensine   converting  enzyme inhibitors, calcium channel blockers and beta-blockers as monotherapy and combination

Environmental factors’ influence on blood pressure variability and circadian rhythm in arterial hypertension patients

Aim. Using twin models, to demonstrate the leading role of environmental factors for blood pressure (BP) variability (Var) and circadian rhythm (CR) parameters. Material and methods. In total, 74 twin pairs with normal BP (mean age 42,4±2,3 years) and 64 twin pairs with arterial hypertension (AH) (mean age 52,76±3,2 years) were examined. Simultaneous pair-wise 24-hour BP monitoring (BPM) was performed with АВРМ-02 device (“MEDITECH”, Hungary). Var of mean systolic BP (VMSBP), mean diastolic BP (DBP), mean hemodynamic BP (VMBP) and mean pulse BP (VPBP) was investigated, as well as Var of mean heart rate (HR) and circadian indices (CI) for SBP, DPB and MBP. Results. In participants with normal BP, environmental factors played the leading role in forming BP Var parameters. In AH patients, hereditary factors input in daytime VPBP was about 21%. Nighttime VSBP and VMBP were genotype-influenced by 22% and 36%, respectively. Random environmental factors were more influential for CIin AH patients; in AH-free individuals, environmental and hereditary factors were equally influential. Conclusion. Random and systematic environmental factors play a leading role in forming BP Var and CR in AH twins, with minimal role of hereditary factors