1 research outputs found
Lack of significant association between Helicobacter pylori infection and homocysteine levels in patients with cardiac syndrome X
Background: Helicobacter pylori (H.pylori) has been implicated in the pathogenesis of
several diseases such as cardiac syndrome X (CSX), which includes chest pain, positive
exercise stress test and normal angiography. Also, elevation of homocysteine (Hcy) level is
associated with CSX, as it can severely disturb vascular endothelial function. We aimed to
elucidate whether the infection of H.pylori affect the level of Hcy in CSX.
Methods: Eighty-eight patients with CSX (32 men, 56 women; mean age: 53.8 ± 11.9) and
97 healthy controls (36 men, 61 women; mean age: 45.7 ± 7.3) were enrolled. Plasma samples
were tested for the presence of IgG antibody to H.pylori using enzyme linked immunosorbent
assay method. Hcy levels were measured enzymatically.
Results: Plasma Hcy concentration in CSX patients is higher than control group (13.1 ± 2.6
vs. 11.8 ± 2.5 mmol/L; p = 0.002). There was no significant difference between Hcy in H.pylori+
and H.pylori– individuals in CSX group (13.1 ± 2.7 vs. 12.2 ± 0.6 mmol/L; p = 0.554) and
between two groups in controls, respectively (12.1 ± 2.2 vs. 11.4 ± 2.9 mmol/L; p = 0.148).
Conclusions: Although there is Hcy level increase in H.pylori+ CSX patients and controls
comparing to H.pylori– subjects, but other factors may affect on Hcy level, too. (Cardiol J 2012;
19, 5: 466-469