COULD AFFECTIVE TEMPERAMENT PREDICT OBSESSIVE COMPULSIVE SYMPTOM DIMENSIONS?

Background: In this study, we aimed to investigate the relationship between affective temperament characteristics and obsessive- compulsive disorder (OCD) symptom dimensions and severity. Subjects and Methods: 100 patients diagnosed with OCD and 100 healthy controls by random sampling method were included in the study. SCID-5-CV was administered to all participants. Dimensional Obsessive-Compulsive Scale (DOCS), Temperament Evaluation of Memphis, Pisa, Paris, San Diego Autoquestionnaire (TEMPS-A), Beck Anxiety (BAI), Depression Inventories (BDI) were provided to all participants. p<0.05 was taken as statistically significant. Results: It was found that cyclothymic temperament predicted all OCD symptom dimensions except contamination dimension, and predicted the OCD severity. Moreover, irritable temperament predicted the OCD symmetry dimension. Conclusion: In our study, the first study in terms of scrutinizing the relationship between symptom dimensions of OCD and affective temperament, it was revealed that irritable and cyclothymic temperament significantly predicted the dimensions of OCD, and cyclothymic temperament was associated with OCD severity. Affective temperaments appear to make a remarkable contribution to OCD heterogeneity

Resilience and traumatic childhood experiences of patients with opioid use disorder

We aim to explore childhood traumatic experiences and resilience of patients with OUD and compare these variables to healthy controls. Ninety-five patients and 83 healthy controls completed the Sociodemographic Data Form, Connor Davidson Psychological Resilience Scale (CDRS), and Childhood Trauma Questionnaire-33 (CTQ-33). We found that CTQ correlated negatively with CDRS in patients. T-test results showed significant differences between both groups regarding total and subscales’ scores of CTQ-except overprotection-over control. Physical neglect predicted a decrease in resilience in patients with OUD. In conclusion, childhood traumas and resilience could be essential factors during patients’ follow-up and treatment process with OUD. © 2023 Taylor & Francis Group, LLC

OPRD1 rs569356 polymorphism has an effect on plasma norbuprenorphine levels and dose/kg-normalized norbuprenorphine values in individuals with opioid use disorder

This study aimed to determine the effects of nine OPRM1, OPRD1 and OPRK1 polymorphisms on plasma BUP and norbuprenorphine (norBUP) concentrations and various treatment responses in a sample of 122 patients receiving BUP/naloxone. Plasma concentrations of BUP and norBUP were detected by LC–MS/MS. PCR-RFLP method was used to genotype polymorphisms. OPRD1 rs569356 GG had significantly lower plasma norBUP concentration (p = 0.018), dose- (p = 0.049) and dose/kg-normalized norBUP values (p = 0.036) compared with AA. Craving and withdrawal symptoms were significantly higher in OPRD1 rs569356 AG+GG relative to AA. There was a statistically significant difference between the OPRD1 rs678849 genotypes in the intensity of anxiety (13.5 for CT+TT and 7.5 for TT). OPRM1 rs648893 TT (18.8 ± 10.8) was significantly different to CC+CT (14.82 ± 11.3; p = 0.049) in view of the intensity of depression. This current study provides the first data on a prominent effect of the OPRD1 rs569356 variation on BUP pharmacology due to its metabolite norBUP. © 2023 Elsevier B.V