Design and experiment of a bionic flapping wing mechanism with flapping–twist–swing motion based on a single rotation

In the present study, a bionic flapping mechanism of a spatial six-bar configuration was designed to transform a single rotation of a motor into a three degrees of freedom “flapping–twist–swing” cooperative motion of a flapping wing. The kinematics model of the flapping mechanism movement was constructed. The flapping trajectory of the wing based on the kinematics model was to mimic the motion of a pigeon wing in landing flight. To reduce the manufacturing complexity, the flapping mechanism was simplified with only two degrees of freedom (flapping and twist) retained. Finally, a prototype model with a 0.9 m wing span was built and tested. A comparison among the experimental data, theoretical calculation results, and ADAMS simulation results revealed that the difference in the flapping and the twist amplitude between experimental observations and theoretical calculation results was 12.5% and 2.3%, respectively. This was owing to the elastic deformation of the bar and the mechanism simplification. The comparison results also indicated that the maximum difference in the inertial force was 5.9% in up-stroke and 6.7% in down-stroke, respectively. The experimental results showed that the inertial force of the model with the wing patagium was approximately 2.2 N, and the maximum positive and negative lift was 2.1 N and −1.5 N, respectively. It is hoped that this study can provide guidance for the design of bionic flapping wing mechanisms of a flapping wing aircraft for short landing flight

Aerodynamic analysis of a flapping wing aircraft for short landing

An investigation into the aerodynamic characteristics has been presented for a bio-inspired flapping wing aircraft. Firstly, a mechanism has been developed to transform the usual rotation powered by a motor to a combined flapping and pitching motion of the flapping wing. Secondly, an experimental model of the flapping wing aircraft has been built and tested to measure the motion and aerodynamic forces produced by the flapping wing. Thirdly, aerodynamic analysis is carried out based on the measured motion of the flapping wing model using an unsteady aerodynamic model (UAM) and validated by a computational fluid dynamics (CFD) method. The difference of the average lift force between the UAM and CFD method is 1.3%, and the difference between the UAM and experimental results is 18%. In addition, a parametric study is carried out by employing the UAM method to analyze the effect of variations of the pitching angle on the aerodynamic lift and drag forces. According to the study, the pitching amplitude for maximum lift is in the range of 60°~70° as the flight velocity decreases from 5 m/s to 1 m/s during landing

An Improved Biometric-Based User Authentication Scheme for C/S System

The authors first review the recently proposed Das's biometric-based remote user authentication scheme, and then show that Das's scheme is still insecure against some attacks and has some problems in password change phase. In order to overcome the design flaws in Das's scheme, an improvement of the scheme is further proposed. Cryptanalysis shows that our scheme is more efficient and secure against most of attacks; moreover, our scheme can provide strong mutual authentication by using verifying biometric, password as well as random nonces generated by the user and server

Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory and Cognitive Impairment Induced by Multiple Cerebral Infarctions

This study aimed to illustrate the mechanism by which Shenmayizhi decoction (SMYZD) improves the learning memory of rats with vascular cognitive impairment (VCI). Fifty male and female Wistar rats of specific pathogen-free grade (SPF grade) were used to establish the model by the administration of a microsphere embolization. This was accomplished by injecting sterile, standardized, mass-produced microspheres of uniform particle size (100–200 µm in diameter) in a sodium alginate microsphere vascular embolic agent suspension to induce VCI. The VCI model was successfully established in 40 rats, including both male and female rats, and the rats were randomly divided into 4 groups of 10 rats each. The model group was administered an equal volume of distilled water. The donepezil group was administered 0.45 mg/kg/d donepezil, which is equivalent to the clinical dosage. The SMYZ-H group was administered 11.88 g/kg/d SMYZ, which is 4 times higher than the clinically equivalent dosage. The SMYZ-L group was administered 2.97 g/kg/d SMYZ, which is the clinically equivalent dosage. A sham-operated group was used as the control group and administered an equal volume of distilled water. The rats in the 4 groups were treated by gavage with equal volumes of liquid and the indicated concentration of drug diluted in distilled water for 8 consecutive weeks. Two months later, the Morris water maze (MWM) was used to evaluate the spatial memory of all the rats. Ultrastructural and ultrapathological changes in the capillaries of the cerebral cortex were observed by transmission electron microscopy. Furthermore, Western blot and RT-PCR analyses were used to assess the levels of platelet-derived growth factor receptor-β (PDGFR-β), neuron-glial antigen 2 (NG2), vascular endothelial growth factor A (VEGF-A), and angiopoietin 1 (Ang1) in the cerebral cortex of the rats. The results showed that SMYZD at concentrations of 11.88 g/kg/d and 2.97 g/kg/d (SMYZ-H and SMYZ-L) significantly shortened the escape latency (EL). In addition, SMYZ-H significantly prolonged the distance traveled and the time spent in the original platform quadrant by the rats with VCI. SMYZ-H significantly increased the NG2 and Ang1 protein expression levels and increased the PDGFR-β and Ang1 mRNA levels. These results demonstrated that Shenmayizhi decoction can improve the memory abilities of rats with VCI induced by multiple cerebral infarctions by preventing pericyte degeneration

Hepatic involvement by T-cell neoplasms: a clinicopathologic study of 40 cases

Hepatic involvement by a T-cell neoplasm is rare and often challenging to diagnose in liver biopsies. We collected 40 cases of T-cell neoplasms diagnosed in the liver from five large academic institutions to assess the clinicopathologic features. The patients included 11 women and 29 men, with a median age of 54 (range: 2-75) years and a high mortality rate (31/37, 83.8%). Fourteen (35%) patients were diagnosed with hepatosplenic T-cell lymphoma (HSTCL), 13 (32.5%) peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 (32.5%) other types of T-cell neoplasms. Patients with HSTCL were much younger and had worse survival than PTCL-NOS and other T-cell neoplasms (P \u3c 0.05). On imaging studies, 20 cases (50%) showed abnormalities, including 10 with mass lesions that correlated with normal or cholestatic pattern enzyme elevation. Histomorphological analysis revealed four main patterns; with the exception of mass forming lesions (pattern 4; n = 8), cases with sinusoidal predominant (pattern 1; n = 12), portal predominant with sinusoidal infiltrates (pattern 2; n = 13) or lobular aggregates (pattern 3; n = 5) demonstrated small to medium lymphocytes resembling a reactive/inflammatory process. In addition, we described two cases of T-cell large granular lymphocytic leukemia that mimicked HSTCL, and a case of aggressive post-transplant lymphoproliferative disorder that developed after chronic Epstein-barr virus (EBV) infection, suggesting the importance of EBV testing in some lymphoma cases. As the largest cohort of T-cell neoplasms in liver, our study provides critical data on disease frequency, distribution, and clinicopathologic features that are essential for accurate diagnosis