1,470 research outputs found
1H-Pyrrole-2-carboxylic acid
In the title compound, C5H5NO2, the pyrrole ring and its carboxyl substituent are close to coplanar, with a dihedral angle of 11.7 (3)° between the planes. In the crystal structure, adjacent molecules are linked by pairs of O—H⋯O hydrogen bonds to form inversion dimers. Additional N—H⋯O hydrogen bonds link these dimers into chains extending along the a axis
1-Ethyl-1H,6H-pyrrolo[2,3-c]azepine-4,8(5H,7H)-dione
The title compound, C10H12N2O2, was synthesized by cyclization of 3-(1-ethylpyrrole-2-carboxamido)propanoic acid in the presence of polyphosphoric acid and diphosphorus pentoxide. In the crystal structure, adjacent molecules are linked by N—H⋯O hydrogen bonds, forming chains extending along the b axis
Methyl 3-[(1-butyl-1H-indol-3-yl)carbonylamino]propionate
In the title molecule, C17H22N2O3, the mean plane of the terminal (C=O)OMe fragment and the indole plane form a dihedral angle of 78.94 (3)°. Intermolecular N—H⋯O hydrogen bonds link the molecules into chains extended along the c axis. The crystal packing exhibits π–π interactions, indicated by the short distance of 3.472 (2) Å between the centroids of the five-membered heterocycles of neighbouring molecules
Methyl (1H-pyrrol-2-ylcarbonylamino)acetate
In the crystal structure of the title compound, C8H10N2O3, molecules are linked by N—H⋯O hydrogen bonds, forming ribbons of centrosymmetric dimers extending along the c axis
Heterologous SH3-p85β inhibits influenza A virus replication
Phosphatidylinositol 3-kinase (PI3K)/Akt signalling pathway can support the replication of influenza A virus through binding of viral NS1 protein to the Src homology 3 (SH3) domain of p85β regulatory subunit of PI3K. Here we investigated the effect of heterologously overexpressed SH3 on the replication of different influenza A virus subtypes/strains, and on the phosphorylation of Akt in the virus-infected cells. We found that heterologous SH3 reduced replication of influenza A viruses at varying degrees in a subtype/strain-dependent manner and SH3 overexpression reduced the induction of the phosphorylation of Akt in the cells infected with PR8(H1N1) and ST364(H3N2), but not with ST1233(H1N1), Ph2246(H9N2), and Qa199(H9N2). Our results suggest that interference with the NS1-p85β interaction by heterologous SH3 can be served as a useful antiviral strategy against influenza A virus infection
Potential super-hard Osmium di-nitride with fluorite structure: First-principles calculations
We have performed systematic first-principles calculations on di-carbide,
-nitride, -oxide and -boride of platinum and osmium with the fluorite
structure. It is found that only PtN, OsN and OsO are
mechanically stable. In particular OsN has the highest bulk modulus of
360.7 GPa. Both the band structure and density of states show that the new
phase of OsN is metallic. The high bulk modulus is owing to the strong
covalent bonding between Os 5\textit{d} and N 2\textit{p} states and the dense
packed fluorite structure.Comment: Phys. Rev. B 74,125118 (2006
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