Well-being and ill-being on campus

Enquiries into the low mental health of university students are exposing the relative merits of competing theoretical and empirical models. The debate is important because the models used to characterise the problem imply alternative causations, consequences, and possible interventions. The purpose of our study is to highlight the value of recognising the presence of both well-being and ill-being within individual students (the dual continua model) as opposed to viewing their well-being and ill-being as opposite ends of a single continuum of mental health (the bipolar model). Using a baseline survey completed by 1,581 first year undergraduate students who enrolled in a New Zealand university at the beginning of 2019, we document the inverse correlation between their scores on the WHO-5 measure of psychological well-being and the PHQ-9 measure of psychological distress or ill-being. Contrary to the assumption of the bipolar model we find their inverse correlation is not strong and that many students are located off the diagonal, some reporting both high well-being and high ill-being over the two-week reference period and many more recording low scores on both screening instruments. We represent this heterogeneity in terms of six clusters of students based on a latent profile analysis of their two scores. We also find that students’ well-being and ill-being respond differently to variations in their physical and financial health both in cross-section and over time, confirming that well-being and ill-being can also be functionally independent. The results are important both diagnostically and in terms of the interventions they suggest

Deep Learning-based Image Analysis for High-content Screening

High-content screening is an empirical strategy in drug discovery toidentify substances capable of altering cellular phenotype — the set ofobservable characteristics of a cell — in a desired way. Throughout thepast two decades, high-content screening has gathered significant attentionfrom academia and the pharmaceutical industry. However, imageanalysis remains a considerable hindrance to the widespread applicationof high-content screening. Standard image analysis relies on feature engineeringand suffers from inherent drawbacks such as the dependence onannotated inputs. There is an urging need for reliable and more efficientmethods to cope with increasingly large amounts of data produced. This thesis centres around the design and implementation of a deeplearning-based image analysis pipeline for high-content screening. Theend goal is to identify and cluster hit compounds that significantly alterthe phenotype of a cell. The proposed pipeline replaces feature engineeringwith a k-nearest neighbour-based similarity analysis. In addition, featureextraction using convolutional autoencoders is applied to reduce thenegative effects of noise on hit selection. As a result, the feature engineeringprocess is circumvented. A novel similarity measure is developed tofacilitate similarity analysis. Moreover, we combine deep learning withstatistical modelling to achieve optimal results. Preliminary explorationssuggest that the choice of hyperparameters have a direct impact on neuralnetwork performance. Generalised estimating equation models are usedto predict the most suitable neural network architecture for the input data. Using the proposed pipeline, we analyse an extensive set of images acquiredfrom a series of cell-based assays examining the effect of 282 FDAapproved drugs. The analysis of this data set produces a shortlist of drugsthat can significantly alter a cell’s phenotype, then further identifies fiveclusters of the shortlisted drugs. The clustering results present groups ofexisting drugs that have the potential to be repurposed for new therapeuticuses. Furthermore, our findings align with published studies. Comparedwith other neural networks, the image analysis pipeline proposedin this thesis provides reliable and better results in a shorter time frame.</p

Well-being and ill-being on campus

Enquiries into the low mental health of university students are exposing the relative merits of competing theoretical and empirical models. The debate is important because the models used to characterise the problem imply alternative causations, consequences, and possible interventions. The purpose of our study is to highlight the value of recognising the presence of both well-being and ill-being within individual students (the dual continua model) as opposed to viewing their well-being and ill-being as opposite ends of a single continuum of mental health (the bipolar model). Using a baseline survey completed by 1,581 first year undergraduate students who enrolled in a New Zealand university at the beginning of 2019, we document the inverse correlation between their scores on the WHO-5 measure of psychological well-being and the PHQ-9 measure of psychological distress or ill-being. Contrary to the assumption of the bipolar model we find their inverse correlation is not strong and that many students are located off the diagonal, some reporting both high well-being and high ill-being over the two-week reference period and many more recording low scores on both screening instruments. We represent this heterogeneity in terms of six clusters of students based on a latent profile analysis of their two scores. We also find that students’ well-being and ill-being respond differently to variations in their physical and financial health both in cross-section and over time, confirming that well-being and ill-being can also be functionally independent. The results are important both diagnostically and in terms of the interventions they suggest

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