Quality of life in hidradenitis suppurativa: an update

Knowledge on hidradenitis suppurativa/acne inversa (HS) is rapidly increasing. HS has a profound impact on patients and their family life. Several factors, such as comorbidities, unemployment and HS severity, make this impact even more severe. The most widely used instrument to measure this impact is the dermatology-specific DLQI. We also identified six HS-specific health-related quality of life (HRQoL) instruments. Of them, HIDRAdisk, HSIA, HiSQOL and HSQoL-24 are better validated but there is still lack of experience of its use. Several treatment methods showed positive effect on patients’ HRQoL. Surgery remains a method with a substantial positive effect on HRQoL. Several studies confirming a positive effect of adalimumab on the HRQoL of patients with HS were published during the last three years. Data on the influence of several other biologics on HRQoL of HS patients are controversial or based on studies with a small number of patients

Thermoelastic Diffusion Multicomponent Half-Space under the Effect of Surface and Bulk Unsteady Perturbations

This article presents an algorithm for solving the unsteady problem of one-dimensional coupled thermoelastic diffusion perturbations propagation in a multicomponent isotropic half-space, as a result of surface and bulk external effects. One-dimensional physico-mechanical processes, in a continuum, have been described by a local-equilibrium model, which included the coupled linear equations of an elastic medium motion, heat transfer, and mass transfer. The unknown functions of displacement, temperature, and concentration increments were sought in the integral form, which was a convolution of the surface and bulk Green’s functions and external effects functions. The Laplace transform on time and the Fourier sine and cosine transforms on the coordinate were used to find the Green’s functions. The obtained Green’s functions was analyzed. Test calculations were performed on the examples of some technological processes