An Mhc Component to Kin Recognition and Mate Choice in Birds: Predictions, Progress, and Prospects

The major histocompatibility complex (Mhc) has been identified as a locus influencing disease resistance, mate choice, and kin recognition in mammals and fish. However, it is unclear whether the mechanisms by which Mhc genes influence behavior in mammals are applicable to other nonmammalian vertebrates such as birds. We review the biology of Mhc genes with particular reference to their relevance to avian mating and social systems. New genomics approaches recently have been applied to the Mhcs of chickens, quail, and several icons of avian behavioral ecology, including red-winged blackbirds (Agelaius phoeniceus) and house finches (Carpodacus mexicanus). The predominance of concerted evolution at avian Mhc loci makes such methods attractive for providing access to this complicated multigene family. Although some biological processes influenced by Mhc in mammals are physiologically implausible for birds, Mhc could influence cues that form well-known bases for mate choice in birds by influencing the health and vigor of individuals. The tight associations of Mhc variation and disease resistance in chickens raise hope that finding associations of Mhc genes, disease, and mate choice in natural populations of birds will be as fruitful as in mammalian systems.Organismic and Evolutionary Biolog

Incaprettamento: An Unusual Homicide by Ligature Strangulation

Abstract: This case study regards the murder of a Tunisian national residing in a small town in southern Italy who was murdered by fellow Tunisian citizen, also living in Italy. The victim was found hogtied and hanged by a cord that was suspended from an iron staff situated between two concrete electrical poles. This method of killing is known as "incaprettemento". It is an unusual type of strangulation whereby a rope is passed around the victim's wrists, ankles, and throat causing suffocation. This results in a very slow and painful death. Typically, it is a method employed by Italian organized crime groups, but it has also been used in the execution of war crimes. This means of killing is meant to impart a particularly degrading and humiliating revenge on the victim. It may also serve as sign of intimidation and a warning to others. There is very little written about incaprettamento in the literature, but it has, nonetheless, important psychological, anthropological, and cultural implications in the field of criminology. The perpetrator underwent psychodiagnostic evaluations, and was ultimately deemed fit to stand trial

Cerebrospinal fluid biomarkers in patients with epilepsy in Alzheimer's disease: a nation-wide study

Alzheimer’s disease is the most common neurodegenerative dementia. A subset of Alzheimer’s disease patients develop epilepsy. The risk is higher in young-onset Alzheimer’s disease, but pathophysiological mechanisms remain elusive. The purpose of this study was to assess biomarkers reflecting neurodegeneration in Alzheimer’s disease patients with and without epilepsy. By cross-referencing the largest national laboratory database with Swedish national patient registers, we could identify cerebrospinal fluid biomarker results from 17901 Alzheimer’s disease patients, and compare levels of neurofilament light, glial fibrillary acidic protein, total tau, phosphorylated tau, and amyloid beta 42 in patients with (n = 851) and without epilepsy. The concentrations of total tau and phosphorylated tau were higher in Alzheimer’s disease patients with epilepsy than Alzheimer’s disease patients without epilepsy and amyloid beta 42 levels were significantly lower in Alzheimer’s disease patients with epilepsy. No differences in the levels of neurofilament light and glial fibrillary acidic protein were observed. Our study suggests that epilepsy is more common in Alzheimer’s disease patients with more pronounced Alzheimer’s pathology, as determined by the CSF biomarkers. Further studies are needed to investigate the biomarker potential of these CSF markers as predictors of epilepsy course or as indicators of epileptogenesis in Alzheimer’s disease

Infections in status epilepticus: A retrospective 5-year cohort study

AbstractPurposeStatus epilepticus (SE) has attracted renewed interest lately, and efforts are made to optimize every treatment stage. For refractory SE, optimal supporting care involves mechanical ventilation and intensive care unit (ICU) admission. Infections often complicate SE and recently a single-centre observational study demonstrated an association between infections and poor short-term outcome of SE in a cohort of severely ill patients. We have here attempted to replicate those findings in a different cohort.MethodWe performed a retrospective observational study and included all patients with a diagnosis of SE during 2008–2012 at a Swedish tertiary referral centre.ResultsThe cohort consisted of 103 patients (53% female, 47% male, median age 62 years, range 19–87 years). In house mortality was less than 2 and 70% of the patients’ were discharged home. The most common aetiologies of SE were uncontrolled epilepsy (37%) and brain tumours (16%). A total of 39 patients suffered infections during their stay. Presence of infection was associated with mechanical ventilation (OR 3.344, 95% CI 1.44–7.79) as well as not being discharged home (OR2.705, 95% CI 1.14–6.44), and duration of SE was significantly longer in patients with infection (median 1 day vs. 2.5 days, p<0.001).ConclusionWe conclude that the previously described association between infections, a longer SE duration, and an unfavourable outcome of SE seems valid also in SE of less severe aetiology