Impact of Project Leadership on Project Success: Mediated by Project Governance and Moderated by Goal Clarity

This study investigates the connections between project leadership, governance, goal clarity, and project success in Pakistan's Civil Engineering (Private) sector. Data was collected from employees using a quantitative approach. A questionnaire was distributed to gather information on project governance, goal clarity, and project success. The results showed a strong relationship between project leadership and project success, with a robust governance framework impacting project leadership effectiveness. Goal clarity moderated the relationship, emphasising the importance of well-defined objectives. The study emphasises the critical role of project leadership in Pakistan's civil engineering sector, emphasising the importance of solid project management frameworks and clear objectives. This information is crucial for organisations and project managers seeking to improve project performance in the dynamic environment of Pakistani civil engineering projects

A Novel Control Approach to Hybrid Multilevel Inverter for High-Power Applications

This paper proposes a hybrid control scheme for a newly devised hybrid multilevel inverter (HMLI) topology. The circuit configuration of HMLI is comprised of a cascaded converter module (CCM), connected in series with an H-bridge converter. Initially, a finite set model predictive control (FS-MPC) is adopted as a control scheme, and theoretical analysis is carried out in MATLAB/Simulink. Later, in the real-time implementation of the HMLI topology, a hybrid control scheme which is a variant of the FS-MPC method has been proposed. The proposed control method is computationally efficient and therefore has been employed to the HMLI topology to mitigate the high-frequency switching limitation of the conventional MPC. Moreover, a comparative analysis is carried to illustrate the advantages of the proposed work that includes low switching losses, higher efficiency, and improved total harmonic distortion (THD) in output current. The inverter topology and stability of the proposed control method have been validated through simulation results in MATLAB/Simulink environment. Experimental results via low-voltage laboratory prototype have been added and compared to realize the study in practice.publishedVersio

Closed-loop elastic demand control under dynamic pricing program in smart microgrid using super twisting sliding mode controller

Electricity demand is rising due to industrialisation, population growth and economic development. To meet this rising electricity demand, towns are renovated by smart cities, where the internet of things enabled devices, communication technologies, dynamic pricing servers and renewable energy sources are integrated. Internet of things (IoT) refers to scenarios where network connectivity and computing capability is extended to objects, sensors and other items not normally considered computers. IoT allows these devices to generate, exchange and consume data without or with minimum human intervention. This integrated environment of smart cities maintains a balance between demand and supply. In this work, we proposed a closed-loop super twisting sliding mode controller (STSMC) to handle the uncertain and fluctuating load to maintain the balance between demand and supply persistently. Demand-side load management (DSLM) consists of agents-based demand response (DR) programs that are designed to control, change and shift the load usage pattern according to the price of the energy of a smart grid community. In smart grids, evolved DR programs are implemented which facilitate controlling of consumer demand by effective regulation services. The DSLM under price-based DR programs perform load shifting, peak clipping and valley filling to maintain the balance between demand and supply. We demonstrate a theoretical control approach for persistent demand control by dynamic price-based closed-loop STSMC. A renewable energy integrated microgrid scenario is discussed numerically to show that the demand of consumers can be controlled through STSMC, which regulates the electricity price to the DSLM agents of the smart grid community. The overall demand elasticity of the current study is represented by a first-order dynamic price generation model having a piece-wise linear price-based DR program. The simulation environment for this whole scenario is developed in MATLAB/Simulink. The simulations validate that the closed-loop price-based elastic demand control technique can trace down the generation of a renewable energy integrated microgrid

Health Care Associated Infections (HCAIs) a New Threat for World; U-Turn from Recovery to Death

Health care associated infections also termed as nosocomial infections are notable cause of morbidity and mortality especially in resource limited countries like Pakistan. Newborns and aged people have more probability of being infected by Health care associated infections because of immunosuppressant. Central line associated blood stream infections (CLABSI) are considered as one of the promising negotiator associated with Health Care associated infections. Improper health care setting and unaware medical staff play a championship protagonist in prevalence of health care associated infections. Standard hygienic measures should be adopted to reduce risk of Health care associated infections. So, there is a pressing need to take on control policies by Government to handle this dilemma. This chapter gives new intuition to healthcare associated microbes, infections and provides comprehensive detailed on ironic precaution to scientific community

Role of deep brain stimulation (DBS) in addiction disorders

Background: Addiction disorders pose significant challenges to public health, necessitating innovative treatments. This assesses deep brain stimulation (DBS) as a potential intervention for addiction disorders. Methods: A literature review was carried out with a focus on the role of DBS in addiction disorders and its future implications in neurosurgical research. Results: The online literature shows that DBS precisely modulates certain brain regions to restore addiction-related neural circuits and promote behavioral control. Conclusion: Preclinical evidence demonstrates DBS’s potential to rebalance neural circuits associated with addiction, and early clinical trials provide encouraging outcomes in enhancing addiction-related outcomes. Ethical considerations, long-term safety, and personalized patient selection require further investigation

Streptococcus thermophilus and Lactococcus lactis : lactic acid bacteria as tools for the production of bioactive peptides? : Effect of proteolytic system on the stability of peptides and heterologous production of an anxiolytic peptide, [alpha]-casozepine

La conception de nouveaux produits laitiers fermentés fonctionnalisés avec les peptides bioactifs est l'une des stratégies prometteuses pour le développement d'aliments fonctionnels. L'objectif de cette thèse s'inscrit ainsi dans une démarche de production d'un lait fermenté contenant un peptide anxiolytique, l'alpha-casozépine (alpha-CZP ; f91-100 de la CN-alpha s1 bovine) ou du fragment plus court (f91-97). Dans un premier temps, nous avons étudié la stabilité des peptides bioactifs vis-à-vis des souches ayant le phénotype PrtS+ (LMD-9) et PrtS- (CNRZ1066) de S. thermophilus. Il s'est avéré que les deux souches sont capables d'hydrolyser le peptide en fragments plus courts par l'activité peptidasique de surface. Il a été vérifié que l'hydrolyse n'est due ni aux peptidases intracellulaires issues d'une éventuelle lyse cellulaire ni à la protéase chaperonne HtrA. Les activités de type amino-, X-prolyl dipeptidyl-, carboxy-peptidases et peptidyl dipeptidase de surface ont été mises en évidence. L'ajout de peptides bioactifs dans des laits fermentés nécessite donc la caractérisation préalable du potentiel protéolytique des bactéries lactiques. Afin de n'ajouter qu'un type de peptides et non pas une fraction peptidique, nous avons exprimé de manière hétérologue l'alpha-CZP sous forme multimérique chez L. lactis en utilisant le système d'induction NICE. Il a été révélé par le test ELISA qu'une petite quantité d'alpha-CZP multimérique a été produite par les cellules induites mais également non induites par la nisine. Le ralentissement important de la croissance des cellules de L. lactis recombinante induites par la nisine suggère que le multimère peptidique a des effets toxiques sur les cellulesThe designing of novel fermented milk products functionalized with bioactive peptides is one of the promising strategies to develop functional foods. The objective of the thesis is thus the development of fermented milks comprising of an anxiolytic peptide, alpha-casozepine (f91-100 of bovine alpha s1 CN) or its shorter fragment (f91 97). Firstly, we studied the stability of different bioactive peptides towards two strains, with PrtS+ (LMD¬9) and PrtS- (CNRZ1066) phenotypes, of S. thermophilus, a starter bacterium widely used for the manufacture of yogurt. It was revealed that both strains hydrolysed the peptides into shorter fragments by surface peptidases. The hydrolysis was neither due to intracellular peptidases eventually released from cell lysis nor to extracellular chaperone protease HtrA, since mutant LMD-9-deltahtrA also showed the same type of hydrolysis. Aminopeptidase, X-prolyl dipeptidyl peptidase, peptidyl dipeptidase and carboxypeptidase activities associated to the cell-surface of both strains were observed. Therefore, addition of bioactive peptides in fermented milks requires well prior characterization of the proteolytic potential of lactic acid bacteria. Finally, in order to add only one type of peptides instead of a peptide fraction, we expressed heterologously alpha-CZP in multimeric form in L. lactis using NICE system. It was revealed by ELISA test that a small quantity of recombinant alpha-CZP multimer was produced by both nisin-induced as well as non-induced cells. The significant decrease in the growth of nisin-induced recombinant L. lactis suggests that the peptide multimer has toxic effects on the cell

Islamic Commercial Law and Economic Development

(Statement of Responsibility) by Zeeshan Javed Hafeez(Thesis) Thesis (B.A.) -- New College of Florida, 2005(Electronic Access) RESTRICTED TO NCF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE(Bibliography) Includes bibliographical references.(Source of Description) This bibliographic record is available under the Creative Commons CC0 public domain dedication. The New College of Florida, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.(Local) Faculty Sponsor: Hicks, Barbar

Prospectives of Antihypertensive Nano-ceuticals as Alternative Therapeutics

International audienc

Prospectives of Antihypertensive Nano-ceuticals as Alternative Therapeutics

International audienc