Ontology Evolution Using Ontology Templates

Evolving ontologies by domain experts is difficult and typically cannot be performed without the assistance of an ontology engineer. This process takes long time and often recurrent modeling errors have to be resolved. This paper proposes a technique for creating controlled ontology evolution scenarios that ensure consistency of the possible ontology evolution and give guarrantees to the domain expert that his/her updates do not cause inconsistency. We introduce ontology templates that formalize the notion of controlled evolution and define ontology template consistency checking service together with a consistency checking algorithm. We prove correctness and demonstate the practical use of the techniques in two scenarios

still a concern in patients with haematological malignancies and stem cell transplant recipients-authors' response

publishersversionpublishe

Resource Annotation Tool.

Available from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi

Data Warehouse, Scripting Language, Data Pump, Data Mining

The bottleneck of a data warehouse implementation is the ETL (extraction, transformation, and load) process, which carries out the initial population of the data warehouse and its further (usually periodical) updates. There is a number of software products supporting the OLAP analysis. However, the ETL process implementation is not repeatable in a significant way. This paper reports on a research of a model-based data transformation applicable to data warehouse population and updates. The ETL process is based on a metadata repository, which contains data models of the data sources, the target data warehouse model, and the correspondence among them

Zabezpeceni dat pro evidenci kulturnich pamatek.

Available from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi

Technicke reseni evidence a inventarizace kulturnich pamatek.

Available from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi

Dynamicke rozhrani mezi systemem pro evidenci a systemem pro inventarizaci kulturnich pamatek.

Available from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi

On Updating the Data Warehouse from Multiple Data Sources.

Available from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi

Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry

Saprochaete and Geotrichum spp. are rare emerging fungi causing invasive fungal diseases in immunosuppressed patients and scarce evidence is available for treatment decisions. Among 505 cases of rare IFD from the FungiScope\u2122 registry, we identified 23 cases of invasive infections caused by these fungi reported from 10 countries over a 12-year period. All cases were adults and previous chemotherapy with associated neutropenia was the most common co-morbidity. Fungaemia was confirmed in 14 (61%) cases and deep organ involvement included lungs, liver, spleen, central nervous system and kidneys. Fungi were S.\ua0capitata (n=14), S.\ua0clavata (n=5), G.\ua0candidum (n=2) and Geotrichum spp. (n=2). Susceptibility was tested in 16 (70%) isolates. All S.\ua0capitata and S.\ua0clavata isolates with the exception of one S.\ua0capitata (MIC 4\ua0mg/L) isolate had MICs>32\ua0mg/L for caspofungin. For micafungin and anidulafungin, MICs varied between 0.25 and >32\ua0mg/L. One case was diagnosed postmortem, 22 patients received targeted treatment, with voriconazole as the most frequent first line drug. Overall mortality was 65% (n=15). Initial echinocandin treatment was associated with worse outcome at day 30 when compared to treatment with other antifungals (amphotericin B \ub1 flucytosine, voriconazole, fluconazole and itraconazole) (P=.036). Echinocandins are not an option for these infections

Clinical features and prognostic factors of Magnusiomyces (Saprochaete) infections in haematology. A multicentre study of SEIFEM/Fungiscope

Background Our multicentre study aims to identify baseline factors and provide guidance for therapeutic decisions regarding Magnusiomyces-associated infections, an emerging threat in patients with haematological malignancies. Methods HM patients with proven (Magnusiomyces capitatus) M. capitatus or (Magnusiomyces clavatus) M. clavatus (formerly Saprochaete capitata and Saprochaete clavata) infection diagnosed between January 2010 and December 2020 were recorded from the SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group and FungiScope (Global Emerging Fungal Infection Registry). Cases of Magnusiomyces fungemia were compared with candidemia. Results Among 90 Magnusiomyces cases (60 [66%] M. capitatus and 30 (34%) M. clavatus), median age was 50 years (range 2-78), 46 patients (51%) were female and 67 (74%) had acute leukaemia. Thirty-six (40%) of Magnusiomyces-associated infections occurred during antifungal prophylaxis, mainly with posaconazole (n = 13, 36%) and echinocandins (n = 12, 34%). Instead, the candidemia rarely occurred during prophylaxis (p < .0001). First-line antifungal therapy with azoles, alone or in combination, was associated with improved response compared to other antifungals (p = .001). Overall day-30 mortality rate was 43%. Factors associated with higher mortality rates were septic shock (HR 2.696, 95% CI 1.396-5.204, p = .003), corticosteroid treatment longer than 14 days (HR 2.245, 95% CI 1.151-4.376, p = .018) and lack of neutrophil recovery (HR 3.997, 95% CI 2.102-7.601, p < .001). The latter was independently associated with poor outcome (HR 2.495, 95% CI 1.192-5.222, p = .015). Conclusions Magnusiomyces-associated infections are often breakthrough infections. Effective treatment regimens of these infections remain to be determined, but neutrophil recovery appears to play an important role in the favourable outcome