142 research outputs found
A comparison of three fingerstick, whole blood antibody tests for Helicobacter pylori infection: a United States, multicenter trial
We compared three whole blood antibody tests for Helicobacter pylori ( H. pylori ) in a United States, multicenter trial. Methods Patients referred for EGD at three medical centers were recruited. During EGD, biopsies were taken for histology and rapid urease testing (RUT). Immediately after endoscopy, patients underwent the antibody tests (FlexPack HP, Abbott Diagnostics; QuikVue, Quidel Corporation; AccuMeter, ChemTrak) using whole blood obtained by two to three fingersticks. Performance characteristics were calculated for each antibody test using the biopsy-based methods as a gold standard. Results A total of 131 patients participated; 50 (38%) patients had histological evidence of H. pylori infection. Using histology as a gold standard, the sensitivities of FlexPack HP, QuikVue, and Accumeter were 76%, 78%, and 84%, respectively. Specificity was 79% with FlexPack HP and 90% with QuikVue and Accumeter. There were no significant differences in the performance of the three antibody tests though there was a trend toward superior performance for AccuMeter compared to FlexPack HP ( p = 0.019 ). However, RUT proved superior to FlexPack HP using histology as a gold standard ( p = 0.008 ). Using either concordant histology and RUT results or a positive histology or RUT to define active H. pylori infection, there was no statistically significant difference between the antibody tests. Conclusions There were no statistically significant differences in the performance of the three antibody tests. These tests proved only marginally sensitive in detecting patients infected with H. pylori . Clinicians should be aware of the limitations of these tests, particularly when using them as a sole means of testing for H. pylori .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72148/1/j.1572-0241.1999.1135_x.x.pd
Diffusion Thermopower at Even Denominator Fractions
We compute the electron diffusion thermopower at compressible Quantum Hall
states corresponding to even denominator fractions in the framework of the
composite fermion approach. It is shown that the deviation from the linear low
temperature behavior of the termopower is dominated by the logarithmic
temperature corrections to the conductivity and not to the thermoelectric
coefficient, although such terms are present in both quantities. The enhanced
magnitude of this effect compared to the zero field case may allow its
observation with the existing experimental techniques.Comment: Latex, 12 pages, Nordita repor
The work of case managers as experienced by older persons (75+) with multi-morbidity – a focused ethnography
Exercise and Polycystic Ovary Syndrome.
Polycystic ovary syndrome (PCOS) is a complex endocrinopathy affecting both the metabolism and reproductive system of women of reproductive age. Prevalence ranges from 6.1-19.9% depending on the criteria used to give a diagnosis. PCOS accounts for approximately 80% of women with anovulatory infer-tility, and causes disruption at various stages of the reproductive axis. Evidence suggests lifestyle modification should be the first line of therapy for women with PCOS. Several studies have examined the impact of exercise interventions on reproductive function, with results indicating improvements in menstrual and/or ovulation frequency following exercise. Enhanced insulin sensitivity underpins the mechanisms of how exercise restores reproductive function. Women with PCOS typically have a cluster of metabolic abnormalities that are risk factors for CVD. There is irrefutable evidence that exercise mitigates CVD risk factors in women with PCOS. The mechanism by which exercise improves many CVD risk factors is again associated with improved insulin sensitivity and decreased hyperinsulinemia. In addition to cardiometabolic and reproductive complications, PCOS has been associated with an increased prevalence of mental health disorders. Exercise improves psychological well-being in women with PCOS, dependent on certain physiological factors. An optimal dose-response relationship to exercise in PCOS may not be feasible because of the highly individualised characteristics of the disorder. Guidelines for PCOS suggest at least 150 min of physical activity per week. Evidence confirms that this should form the basis of any clinician or healthcare professional prescription
Case managers for older persons with multi-morbidity and their everyday work – a focused ethnography
Polycystic ovary syndrome in familial partial lipodystrophy type 2 (FPLD2): basic and clinical aspects
Phenotypic spectrum of polycystic ovary syndrome and their relationship to the circadian biomarkers, melatonin and cortisol
Understanding human-environment interactions in space and time: 3 case studies from the Holocene in Australia
Understanding human-environment interactions has emerged as a prominent research agenda
within both archaeology and palaeoecology. Palaeoenvironmental research has demonstrated the
important role that climate has in determining the development and distribution of ecosystems,
however the impact of humans on ecosystems and of environmental change on humans remains
contentious, particularly when studies of environmental change are conducted in isolation from
archaeology. Here we present three separate analyses of human-environment interactions through
time in Australia that are focussed at range of spatial scales: local, regional and continental. We
highlight a tight coupling between palaeoenvironmental change and human population dynamics at
all of these scales in the case studies and attempt to disentangle the reciprocal relationships
between environmental change and human activity. The governing question underpinning this
presentation is: how does the information provided by palaeoecology and archaeology about
human-environment interactions through time vary with the spatial and temporal scale of the
primary data? © The Author
A Comparison of Polysomnographic Variables Between Adolescents with Polycystic Ovarian Syndrome with and without the Metabolic Syndrome
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