3 research outputs found

    Study of Diluted Meldonium Solutions by Surface Enhanced Raman Scattering Spectroscopy

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    Silvered porous silicon was utilized as an active substrate for a detection of small amounts of meldonium by surface enhanced Raman scattering (SERS) spectroscopy. We were able to detect the meldonium in its water solutions at the concentrations of 102–106 M. Immersion of the silvered porous silicon in the meldonium solutions at the 104M concentration and lower led to the dimers' formation. At the concentrations larger than 103 M, a greater contribution to the enhancement of the Raman intensity was caused by a chemical mechanism while the smaller amounts were detected mostly due to an electromagnetic mechanism

    High rate dose brachytherapy - HDR experience for localized and locally advanced prostate cancer in Sverdlovsk Regional Oncology Dispensary

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    Currently, the rate of morbidity and mortality from prostate cancer has been increasing. HDR brachytherapy (HDR-Π’Π’) is considered to be one of the modern methods in the treatment of prostate cancer. In Sverdlovsk Regional Oncology Centre (SROC) this method has been being applied since 2009. In our work we analyzed treatment outcomes in 204 patients with localized and locally advanced prostate cancer after HDR as a single method as well as a part of combined and complex treatment. Our results evidenced of HDR brachytherapy as an effective and safe method of treatment, which improves hospitalization.Π’ настоящСС врСмя Π² России отмСчаСтся рост заболСваСмости ΠΈ смСртности ΠΎΡ‚ Ρ€Π°ΠΊΠ° ΠΏΡ€Π΅Π΄ΡΡ‚Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹. Одним ΠΈΠ· соврСмСнных ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² лСчСния Π΄Π°Π½Π½ΠΎΠΉ ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³ΠΈΠΈ являСтся внутритканСвая высокодозная брахитСрапия - HDR (High dose rate). Π’ БвСрдловском областном онкологичСском диспансСрС (Π‘ΠžΠžΠ”) этот ΠΌΠ΅Ρ‚ΠΎΠ΄ лСчСния примСняСтся с 2009 Π³. Π’ Π΄Π°Π½Π½ΠΎΠΉ Ρ€Π°Π±ΠΎΡ‚Π΅ приводится Π°Π½Π°Π»ΠΈΠ· Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ² лСчСния 204 Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… Π»ΠΎΠΊΠ°Π»ΡŒΠ½Ρ‹ΠΌ ΠΈ мСстно-распространСнным Ρ€Π°ΠΊΠΎΠΌ простаты с ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ HDR ΠΊΠ°ΠΊ Π² ΡΠ°ΠΌΠΎΡΡ‚ΠΎΡΡ‚Π΅Π»ΡŒΠ½ΠΎΠΌ ΠΏΠ»Π°Π½Π΅, Ρ‚Π°ΠΊ ΠΈ Π² составС ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΈ/ΠΈΠ»ΠΈ комплСксного лСчСния. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Π΅ Π½Π°ΠΌΠΈ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΡΠ²ΠΈΠ΄Π΅Ρ‚Π΅Π»ΡŒΡΡ‚Π²ΡƒΡŽΡ‚ ΠΎ Ρ‚ΠΎΠΌ, Ρ‡Ρ‚ΠΎ высокодозная брахитСрапия - HDR являСтся эффСктивным ΠΈ бСзопасным ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ лСчСния, Π½Π΅ Ρ‚Ρ€Π΅Π±ΡƒΡŽΡ‰ΠΈΠΌ Π΄Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… сроков госпитализации Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ…

    Postoperative early complications and mortality in patients with bladder cancer undergoing radical cystectomy

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    Radical cystectomy is the standard of care for muscle invasive and re-fractory or recurrent noninvasive bladder cancer. Unfortunately, despite of the recent improvements, radical cystectomy is still associated with high risk of perioper-ative complications and non-negligible risk of mortality. The aim of the present study was evaluation 30-days perioperative complications and mortality rate in our single-center series of radical cystectomy cases based on standardized Clavien-Dindo classification.Радикальная цистэктомия являСтся стандартом лСчСния Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½Ρ‹ΠΌΠΈ ΠΈ Ρ€Π΅Ρ„Ρ€Π°ΠΊΡ‚Π΅Ρ€Π½Ρ‹ΠΌΠΈ ΠΊ ΠΎΡ€Π³Π°Π½ΠΎΡΠΎΡ…Ρ€Π°Π½ΡΡŽΡ‰Π΅ΠΌΡƒ Π»Π΅Ρ‡Π΅Π½ΠΈΡŽ Ρ€Π΅Ρ†ΠΈΠ΄ΠΈΠ²Π½Ρ‹ΠΌΠΈ Π½Π΅ ΠΌΡ‹ΡˆΠ΅Ρ‡Π½ΠΎ-ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½Ρ‹ΠΌΠΈ Ρ„ΠΎΡ€ΠΌΠ°ΠΌΠΈ Ρ€Π°ΠΊΠ° ΠΌΠΎΡ‡Π΅Π²ΠΎΠ³ΠΎ пузыря. К соТалСнию, нСсмотря Π½Π° послСдниС достиТСния ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Ρ‹, Ρ€Π°Π΄ΠΈΠΊΠ°Π»ΡŒΠ½Π°Ρ цистэктомия ΠΏΠΎ-ΠΏΡ€Π΅ΠΆΠ½Π΅ΠΌΡƒ ассоциируСтся с высоким риском развития послСопСрационных ослоТнСний ΠΈ смСртности. ЦСлью настоящСго исслСдования являлась ΠΎΡ†Π΅Π½ΠΊΠ° 30-Ρ‚ΠΈ Π΄Π½Π΅Π²Π½Ρ‹Ρ… послСопСрационных ослоТнСний ΠΈ смСртности Π² нашСй ΠΎΠ΄Π½ΠΎΡ†Π΅Π½Ρ‚Ρ€ΠΎΠ²ΠΎΠΉ сСрии Ρ€Π°Π΄ΠΈΠΊΠ°Π»ΡŒΠ½Ρ‹Ρ… цистэктомий Π½Π° основС стандартизированной классификации КлавьСн-Π”ΠΈΠ½Π΄ΠΎ
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