Effect of Angipars on neuropathic pain in streptozotocin-induced diabetic rats

Introduction: Diabetes is the most common cause of peripheral nerve involvement. Evaluating the effect of antioxidants on diabetic neuropathic pain is important. This study aimed at evaluating the effects of Angipars medicine in the treatment of neuropathic hyperalgesia in single dose streptozotocin-induced diabetic rats. Methods: The study was performed on 50 Spraque dawley rats of 250-300 grams weight. The rats were divided into four groups of control, sham, Angipars-receiving diabetic, and vehicle-receiving diabetic, with at least 8 rats in each group. Diabetes was induced by intraperitoneal injection of 45 mg/kg streptozotocin dissolved in a 0.05 M citrate buffer. After confirming the diabetes, the diabetic rats received (5, 10, 20 mg/kg, intraperitoneal) Angipars and vehicle for 2 weeks. At the end of the eighth week, the control and treated rats were examined through the hot plate and tail flick tests. ANOVA was used to evaluate the statistical difference and P<0.05 was considered as significant. Results: At the end of the eighth week, the response time to thermal hyperalgesia decreased in the vehicle and sham groups compared with the control group. Angipars at doses of 5 and 10 mg increased the response time to thermal hyperalgesia compared to the vehicle and sham groups in hot plate test. In the tail flick test, 10mg Angipars increased the response time to pain similar to the control group. Conclusion: This study showed that, as an antioxidant, Angipars is capable of reducing neuropathic hyperalgesia in animals with diabetes

Hundredfold Enhancement of Light Emission via Defect Control in Monolayer Transition-Metal Dichalcogenides

Two dimensional (2D) transition-metal dichalcogenide (TMD) based semiconductors have generated intense recent interest due to their novel optical and electronic properties, and potential for applications. In this work, we characterize the atomic and electronic nature of intrinsic point defects found in single crystals of these materials synthesized by two different methods - chemical vapor transport and self-flux growth. Using a combination of scanning tunneling microscopy (STM) and scanning transmission electron microscopy (STEM), we show that the two major intrinsic defects in these materials are metal vacancies and chalcogen antisites. We show that by control of the synthetic conditions, we can reduce the defect concentration from above $10^{13} /cm^2$ to below $10^{11} /cm^2$. Because these point defects act as centers for non-radiative recombination of excitons, this improvement in material quality leads to a hundred-fold increase in the radiative recombination efficiency

Interplay between local moment and itinerant magnetism in the layered metallic antiferromagnet TaFe1.14_{1.14}Te3_3

Two-dimensional (2D) antiferromagnets have garnered considerable interest for the next generation of functional spintronics. However, many available bulk materials from which 2D antiferromagnets are isolated are limited by their sensitivity to air, low ordering temperatures, and insulating transport properties. TaFe$_{1+y}$Te$_3$ offers unique opportunities to address these challenges with increased air stability, metallic transport properties, and robust antiferromagnetic order. Here, we synthesize TaFe$_{1+y}$Te$_3$ ($y$ = 0.14), identify its structural, magnetic, and electronic properties, and elucidate the relationships between them. Axial-dependent high-field magnetization measurements on TaFe$_{1.14}$Te$_3$ reveal saturation magnetic fields ranging between 27-30 T with a saturation magnetic moment of 2.05-2.12 $\mu_B$. Magnetotransport measurements confirm TaFe$_{1.14}$Te$_3$ is metallic with strong coupling between magnetic order and electronic transport. Angle-resolved photoemission spectroscopy measurements across the magnetic transition uncover a complex interplay between itinerant electrons and local magnetic moments that drives the magnetic transition. We further demonstrate the ability to isolate few-layer sheets of TaFe$_{1.14}$Te$_3$ through mechanical exfoliation, establishing TaFe$_{1.14}$Te$_3$ as a potential platform for 2D spintronics based on metallic layered antiferromagnets.Comment: 30 pages, 5 main figures, 23 supporting figures, and 3 supporting table

Practical Demonstration and Novel Optimization Control for a Smart Soft Open Point to Maximize the Synergy between the DC Metro Line and the LV Distribution Grid

The steady increment in electrical loads often requires expensive and disruptive upgrading of the electrical power supply infrastructure. This can be avoided by synergizing the DC railway networks with local AC grids using soft-open points to transfer the available regenerative braking energy of the trains to the nearby local grid. Besides, a battery energy storage system is integrated into the soft-open point to match the braking events with the grid load power. So that the new developed system effectively decouples both the rail and grid networks. This paper presents a practical study for such novel rail+grid energy management strategy. A 100kW smart soft open point is designed and implemented in this research to experimentally evaluate the new strategy in a lab environment using real rail data. Afterwards, the developed 100 kW prototype is accordingly validated in the real environment at Metro Madrid, Spain. Lastly, a multi-objectives optimization framework is designed for the developed management system to maximize the synergy between both networks. the multi-objectives framework aims to minimize the power losses in both networks, maximizing the profit of selling the harvested rail power to the grid and finally maximize the penetration level of the available renewables power in the grid