1 research outputs found
Chronic Kidney Disease in Southwestern Iranian Children
Objective: The aim of the study was to determine the etiology of
Chronic Kidney Disease (CKD) among children attending the pediatric
nephrology service at Abuzar children's hospital in Ahvaz city, the
referral center in Southwest of Iran. Methods: We reviewed the
records of 139 children, diagnosed to have CKD over a 10-year period.
CKD was defined a glomerular filtration rate (GFR) below 60 ml/1.73
m2/min persisting for more than 3 months. Findings: Among 139
children 81 (58%) were males. The mean age at diagnosis of CKD in the
patients was 4.2 (±3.6) years. Mean level of serum creatinine at
presentation was 1.9 (±1.4) mg/dl. The mean GFR at presentation
was 33.5 (±15.4) ml/1.73m2/min while 22% of the patients were
already at end stage renal failure indicating that these children were
referred too late. Congenital urologic malformation was the commonest
cause of CKD present in 70 (50.4%) children [reflux nephropathy
(23.1%), hypo/dysplastic kidney (15.8%), obstructive uropathy (10.8%),
and prune belly syndrome (0.7%)]. Other causes included hereditary
nephropathies (17.2%), chronic glomerulo-nephritis (6.5%),
multisystemic diseases (4.3%), miscellaneous and unknown (each one
10.8%). The mean duration of follow-up was 26 (±24.67) months.
Peritoneal or hemodialysis was performed in 10 patients. Six patients
underwent (4 live-related and 2 non-related) renal transplantation. The
rest have died or received standard conservative management for CKD.
Conclusion: The commonest causes of CKD were reflux nephropathy,
hypo/dysplastic kidney, hereditary nephropathy and obstructive
uropathy. Patients presented late, had severe CKD and were malnourished
and stunted