High dose vitamin D supplementation can improve menstrual problems, dysmenorrhea and premenstrual syndrome in adolescents

Vitamin D has a crucial role in female reproduction, possibly through its effects on calcium homeostasis, cyclic sex steroid hormone fluctuations, or neurotransmitter function. We have assessed the effects of vitamin D supplementation on dysmenorrhea and premenstrual syndrome (PMS) in adolescents. In this study, 897 adolescent girls living in Mashhad and Sabzevar, Iran, received 9 high-dose vitamin D supplements (as 50000 IU/ week of cholecalciferol) and were followed up over 9 weeks. We evaluated the effect of vitamin D supplementation on individuals in 4 categories: those with only PMS; individuals with only dysmenorrhea; subjects with both PMS and dysmenorrhea and normal subjects. The prevalence of PMS after the intervention fell from 14.9% to 4.8% (P<0.001). Similar results were also found for the prevalence of subjects with dysmenorrhea (35.9% reduced to 32.4%), and in subjects with both PMS and dysmenorrhea (32.7% reduced 25.7%). Vitamin D supplementation was associated with a reduction in the incidence of several symptoms of PMS such as backache and tendency to cry easily as well decrement in pain severity of dysmenorrhea (P<0.05). High dose vitamin D supplementation can reduced the prevalence of PMS and dysmenorrhea as well has positive effects on the physical and psychological symptoms of PMS

Comparing the effects of peritoneal and subcutaneous injections of Bupivacaine on post-appendectomy pain

Background: This study aimed to compare the effects of peritoneal and subcutaneous injections of bupivacaine 0.5% on post-appendectomy pain and also the efficacy of local anaesthetic injection for postoperative pain relief in peritoneal inflammation with subcutaneous injection. Materials and Methods: This randomized-clinical trial was conducted on 126 participants (age range, 15-45 years) underwent appendectomy for acute appendicitis in Kashan Shahid- Beheshti hospital. Participants were divided into three groups: bupivacaine (0.5%, ip), bupivacaine (0.5% s.c), and control (no injection). Pain intensity was evaluated using the visual analogue scale at 6, 12 and 24 hours after surgery. Results: There was no significant difference among the three groups in age, sex, the duration of anesthesia and surgery. Pain intensity (6 h post-surgery) was significantly higher in the subcutaneous group than the peritoneal group, but no significant difference was seen between the two groups at 12 and 24 h post-surgery. Moreover, pain intensity in the peritoneal and subcutaneous groups was significantly lower than the control group at 6 and 12 h post-surgery (P<0.05). There was a significant difference between the peritoneal and subcutaneous groups as well as between the peritoneal and control groups required analgesics, but the difference was not significant between the subcutaneous and control groups. Conclusion: Although both peritoneal and subcutaneous injections of bupivacaine can reduce postoperative pain in patients undergoing appendectomy, the peritoneal injection can significantly reduce the postoperative analgesic consumption