Sustainable woodland management and livelihood options in a charcoal producing region:An agent-based modelling approach

Woodland resources provide livelihoods for millions of people in Africa. Concerns about the impact of human utilization of woodlands have led to vigorous debates on woodland degradation. Ecological and socio-economic empirical data and understanding of the socio-ecological system have been synthesized in an agent-based model (ABM) to explore different woodland management options for a dynamic, semi-arid region in Kenya. In our simulations we accounted for the impacts of drought frequency, charcoal price changes, improved management practices and taxation of charcoal for a 20-year period to assess woodland changes in a spatially explicit way and evaluate the numbers of actors that can benefit from charcoal harvesting as a livelihood option. The model is based on an agent typology derived from 150 household interviews that focused on livelihood strategies and decision-making processes. Furthermore, the model integrates knowledge from vegetation plots and focus group meetings. From the model simulations we learn that favorable prices, improved management and taxation do not directly have the anticipated impact on woodland resources, as the improved conditions lead to fewer constraints on involvement in charcoal making. This reduces the positive impacts of these measures on the woodland quality but, at the same time, allows a larger number of actors to benefit from charcoal harvesting. Results show a very strong decrease in woodland area under the base scenario thereby reducing possibilities for households to supplement their incomes with charcoal making. Increased droughts and low prices for charcoal lead to early depletion of woodlands and reduction in livelihood options. Taxation stabilizes the number of charcoal producers but does not stop the depletion of woodland area. Woodland loss can only be prevented by controlling the number of charcoal makers and the amount of charcoal harvesting

Suspended and bedload transport in the surfzone : implications for sand transport models

ACKNOWLEDGMENTS The research presented in this paper is conducted within the SINBAD project, funded by STW (12058) and EPSRC (EP/J00507X/1, EP/J005541/1), and received additional funding through the European Community’s FP7 project Hydralab IV (contract no. 261520).Publisher PD

Sand suspension and fluxes by wave groups and equivalent monochromatic waves

We thank the technical staff of the UPC CIEMLAB and Sjoerd van Til for their contributions to the experiments, and the editor and an anonymous reviewer for their useful feedback on the manuscript. The experimental work was supported by the European Community's Seventh Framework Programme through the grant to the budget of the Integrating Activity HYDRALAB IV within the Transnational Access Activities, Contract no. 261520, with additional funding from the Dutch Technology Foundation STW (project 12058) and the UK’s Engineering and Physical Sciences Research Council (EPSRC, grant number EP/J00507X/1) through the SINBAD project. JvdZ was funded through the European Community’s H2020 Programme HYDRALAB+ (Contract no. 654110). The presented data are stored in the 4TU online data repository (https://doi.org/10.4121/uuid:30496cc3-9803-4c18-8a6f-85513bb29c3d).Peer reviewedPostprin

The contribution of charcoal production to rural livelihoods in a semi-arid area in Kenya

Forest incomes in the form of both timber and non-timber forest products are an important source of livelihood for many communities in Africa. A major forest resource is charcoal, which contributes to the livelihoods of millions across the region. While incomes from charcoal are used to meet a wide spectrum of needs within rural livelihoods, the role of charcoal production on livelihoods of small-scale producers is not well understood. Therefore, we provide an example on the importance of charcoal on livelihoods in an agropastoralist community in a semi-arid region in Kenya. Based on a household questionnaire targeting 150 charcoal and 150 non-charcoal makers, as well as focus group discussions, we assessed the determinants for participation in charcoal production and developed a household typology based on charcoal income dependence. We also determined the role of charcoal in income equalization and poverty reduction. Our study shows that charcoal contributes about 20% of the household income in the study area. Gender, land size and the number of food-scarce months are the key determinants of participation in charcoal production. Based on the poverty analysis, we conclude that even though charcoal income does not lift the producers out of poverty, it can mitigate the impacts of poverty by reducing the poverty gap and poverty severity. Based on our findings, we recommend a multipronged approach to address sustainable rural livelihoods including a more explicit acknowledgement of charcoal production as a source of rural income. We also recommend broadening of the local livelihood base and a more active management of the woodland to ensure the sustainability of the income

Androgens and Development of Posttransplantation Diabetes Mellitus in Male Kidney Transplant Recipients:A Post Hoc Analysis of a Prospective Study

OBJECTIVE: Posttransplantation diabetes mellitus (PTDM) effects up to 30% of all kidney transplant recipients (KTR). Recent studies in mice found that sufficient androgen levels are necessary for β-cell health and adequate insulin secretion. This raises the question whether a similar relationship might be present in KTR. Hence, we hypothesized that dihydrotestosterone and testosterone are associated with the development of PTDM in male KTR. RESEARCH DESIGN AND METHODS: We conducted a post hoc analyses of a prospective single-center cohort study including adult male KTR with a functioning graft ≥1 year posttransplantation. Androgen levels were assessed by liquid chromatography-tandem mass spectrometry. Development of PTDM was defined according to the American Diabetes Association's criteria. RESULTS: We included 243 male KTR (aged 51 ± 14 years), with a median dihydrotestosterone 0.9 (0.7-1.3) nmol/L and testosterone of 12.1 (9.4-15.8) nmol/L. During 5.3 (3.7-5.8) years of follow-up, 28 KTR (11.5%) developed PTDM. A clear association was observed, as 15 (19%), 10 (12%), and 3 (4%) male KTR developed PTDM in the respective tertiles of dihydrotestosterone (P = 0.008). In Cox regression analyses, both dihydrotestosterone and testosterone as continuous variables were inversely associated with the risk to development PTDM, independent of glucose and HbA1c (hazard ratio [HR] 0.31 [95%CI 0.16-0.59], P < 0.001; and HR 0.32 [95%CI 0.15-0.68], P = 0.003, respectively). CONCLUSIONS: Our results suggest that low androgen levels are a novel potential modifiable risk factor for the development of PTDM in male KTR

Interleukin 6 and Development of Heart Failure With Preserved Ejection Fraction in the General Population

Background The cause of heart failure with preserved ejection fraction (HFpEF) is poorly understood, and specific therapies are lacking. Previous studies suggested that inflammation plays a role in the development of HFpEF. Herein, we aimed to investigate in community-dwelling individuals whether a higher plasma interleukin 6 (IL-6) level is associated with an increased risk of developing new-onset heart failure (HF) over time, and specifically HFpEF. Methods and Results We performed a case-cohort study based on the PREVEND (Prevention of Renal and Vascular End-Stage Disease) study, a prospective general population-based cohort study. We included 961 participants, comprising 200 participants who developed HF and a random group of 761 controls. HF with reduced ejection fraction or HFpEF was defined on the basis of the left ventricular ejection fraction of 40%, respectively. In Cox proportional hazard regression analyses, IL-6 levels were statistically significantly associated with the development of HF (hazard ratio [HR], 1.28; 95% CI, 1.02-1.61; P=0.03) after adjustment for key risk factors. Specifically, IL-6 levels were significantly associated with the development of HFpEF (HR, 1.59; 95% CI, 1.16-2.19; P=0.004), whereas the association with HF with reduced ejection fraction was nonsignificant (HR, 1.05; 95% CI, 0.75-1.47; P=0.77). In sensitivity analyses, defining HFpEF as left ventricular ejection fraction >= 50%, IL-6 levels were also significantly associated with the development of HFpEF (HR, 1.47; 95% CI, 1.04-2.06; P=0.03) after adjustment for key risk factors. Conclusions IL-6 is associated with new-onset HFpEF in community-dwelling individuals, independent of potential confounders. Our findings warrant further research to investigate whether IL-6 might be a novel treatment target to prevent HFpEF

Comparing the cumulative live birth rate of cleavage-stage versus blastocyst-stage embryo transfers between IVF cycles:a study protocol for a multicentre randomised controlled superiority trial (the ToF trial)

Introduction In vitro fertilisation (IVF) has evolved as an intervention of choice to help couples with infertility to conceive. In the last decade, a strategy change in the day of embryo transfer has been developed. Many IVF centres choose nowadays to transfer at later stages of embryo development, for example, transferring embryos at blastocyst stage instead of cleavage stage. However, it still is not known which embryo transfer policy in IVF is more efficient in terms of cumulative live birth rate (cLBR), following a fresh and the subsequent frozen-thawed transfers after one oocyte retrieval. Furthermore, studies reporting on obstetric and neonatal outcomes from both transfer policies are limited. Methods and analysis We have set up a multicentre randomised superiority trial in the Netherlands, named the Three or Fivetrial. We plan to include 1200 women with an indication for IVF with at least four embryos available on day 2 after the oocyte retrieval. Women are randomly allocated to either (1) control group: embryo transfer on day 3 and cryopreservation of supernumerary good-quality embryos on day 3 or 4, or (2) intervention group: embryo transfer on day 5 and cryopreservation of supernumerary good-quality embryos on day 5 or 6. The primary outcome is the cLBR per oocyte retrieval. Secondary outcomes include LBR following fresh transfer, multiple pregnancy rate and time until pregnancy leading a live birth. We will also assess the obstetric and neonatal outcomes, costs and patients' treatment burden. Ethics and dissemination The study protocol has been approved by the Central Committee on Research involving Human Subjects in the Netherlands in June 2018 (CCMO NL 64060.000.18). The results of this trial will be submitted for publication in international peer-reviewed and in open access journals. Trial registration number Netherlands Trial Register (NL 6857)