461 research outputs found

    Meta-analysis on the Effect of Mild Primary Hyperparathyroidism and Parathyroidectomy upon Arterial Stiffness

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    Context: Current data about the cardiovascular manifestations of mild primary hyperparathyroidism (pHPT) are often conflicting. Pulse wave velocity (PWV) is the gold standard for assessing aortic stiffness, and it predicts cardiovascular morbidity and mortality. Objective: Primary outcomes were to investigate if mild pHPT was associated with higher PWV and if parathyroidectomy (PTX) reduced PWV in mild pHPT. Secondary outcome was to investigate blood pressure changes after PTX. Methods: Sources were PubMed, Google Scholar, SCOPUS, Web of Science, and the Cochrane Library. Eligible studies included reports of PWV in patients with mild pHPT and controls, or in patients with mild pHPT before and after PTX. Two investigators independently identified eligible studies and extracted data. Pooled mean difference (MD) was the summary effect measure. Data were presented in forest plots with outlier and influential case diagnostics. Nine observational studies and one randomized clinical trial were selected, including 433 patients with mild pHPT, 171 of whom underwent PTX, and 407 controls. PWV was significantly higher in mild pHPT than in controls (MD = 1.18, 0.67 to 1.68, P <. 0001). Seven studies evaluated the effect of PTX on PWV. PTX significantly reduced PWV (MD =-0.48,-0.88 to-0.07, P =. 022). Conclusion: Aortic stiffness is increased in patients with mild pHPT, supporting the notion that mild pHPT is also associated with adverse cardiovascular manifestations. PTX significantly reduced arterial stiffness in mild pHPT, indicating that the benefit of PTX over cardiovascular manifestations should not be dismissed but it deserves further studies

    Protocolo para medição de fluxos de gases de efeito estufa do solo.

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    bitstream/item/123470/1/Doc.-265-Protocolo-Josileia.pd

    Methane emission from soil under long-term no-till cropping systems.

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    Methane (CH4) emission from agricultural soils increases dramatically as a result of deleterious effect of soil disturbance and nitrogen fertilization on methanotrophic organisms; however, few studies have attempted to evaluate the potential of long-term conservation management systems to mitigate CH4 emissions in tropical and subtropical soils. This study aimed to evaluate the long-term effect (>19 years) of no-till grass- and legume-based cropping systems on annual soil CH4 fluxes in a formerly degraded Acrisol in Southern Brazil. Air sampling was carried out using static chambers and CH4 analysis by gas chromatography. Analysis of historical data set of the experiment evidenced a remarkable effect of high C- and N-input cropping systems on the improvement of biological, chemical, and physical characteristics of this no-tilled soil. Soil CH4 fluxes, which represent a net balance between consumption () and production (+) of CH4 in soil, varied from 40 2 to +62 78 mg C m2 h1. Mean weighted contents of ammonium (NH4+–N) and dissolved organic carbon (DOC) in soil had a positive relationship with accumulated soil CH4 fluxes in the post-management period (r2 = 0.95, p = 0.05), suggesting an additive effect of these nutrients in suppressing CH4 oxidation and stimulating methanogenesis, respectively, in legumebased cropping systems with high biomass input. Annual CH4 fluxes ranged from 50 610 to +994 105 g C ha1, which were inversely related to annual biomass-C input (r2 = 0.99, p = 0.003), with the exception of the cropping system containing pigeon pea, a summer legume that had the highest biologically fixed N input (>300 kg ha1 yr1). Our results evidenced a small effect of conservation management systems on decreasing CH4 emissions from soil, despite their significant effect restoring soil quality. We hypothesized that soil CH4 uptake strength has been off-set by an injurious effect of biologically fixed N in legume-based cropping systems on soil methanotrophic microbiota, and by the methanogenesis increase as a result of the O2 depletion in niches of high biological activity in the surface layer of the no-tillage soil

    Distribuição das formas de fósforo após 15 anos da adoção de sistemas de manejo.

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    Editado por: Clenio Nailto Pillon, Deborah Pinheiro Dick, Ladislau Martin Neto; Trabalho publicado também em Resumos do NCONTRO BRASILEIRO DE SUBSTÂNCIAS HÚMICAS, 8., 2009, Pelotas

    Protein-like dynamical transition of hydrated polymer chains

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    Combining elastic incoherent neutron scattering experiments at different resolutions and molecular dynamics simulations, we report the observation of a protein-like dynamical transition in Poly(N-isopropylacrylamide) chains. We identify the onset of the transition at a temperature Td of about 225~K. Thanks to a novel global fit procedure, we find quantitative agreement between measured and calculated polymer mean-squared displacements at all temperatures and time resolutions. Our results confirm the generality of the dynamical transition in macromolecular systems in aqueous environments, independently of the internal polymer topology
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