1 research outputs found
Approaches to Correction of Adaptive Responses of Experimental Animals during the Autumnal Equinox
Π Π½Π°ΡΡΠΎΡΡΠ΅ΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π°Π½Π°Π»ΠΈΠ·Π° Π°Π΄Π°ΠΏΡΠΈΠ²Π½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΊΡΡΡ (n = 120, ΡΠ°ΠΌΡΡ Β«WistarΒ») Π² ΠΏΠ΅ΡΠΈΠΎΠ΄ ΠΎΡΠ΅Π½Π½Π΅Π³ΠΎ ΡΠ°Π²Π½ΠΎΠ΄Π΅Π½ΡΡΠ²ΠΈΡ ΠΏΠΎΡΠ»Π΅
ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ΅ΡΡΠΎΠΌΠ»Π΅Π½ΠΈΡ (ΠΏΠ»Π°Π²Π°ΡΠ΅Π»ΡΠ½ΡΠΉ ΡΠ΅ΡΡ) ΠΈ ΡΠ²Π΅ΡΠΎΠ²ΡΡ
Π΄Π΅ΡΠΈΠ½Ρ
ΡΠΎΠ½ΠΎΠ·ΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ
ΠΈΡ
ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠ»ΠΈ ΡΠΈΠ·ΠΈΠΎΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ. Π Π΅Π°Π±ΠΈΠ»ΠΈΡΠΈΡΡΡΡΠΈΠ΅ ΠΏΡΠΎΡΠ΅Π΄ΡΡΡ
ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π²ΠΎΠ΄Π½ΡΡ
ΠΈ ΠΏΠ°Π½ΡΠΎΠ²ΡΡ
Π²Π°Π½Π½ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 10 Π΄Π½Π΅ΠΉ ΡΡΠ°Π·Ρ ΠΏΠΎΡΠ»Π΅ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ
ΡΡΡΠ΅ΡΡ-ΡΠ°ΠΊΡΠΎΡΠΎΠ². Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΠ΅ΡΠ΅ΡΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ΅Π΄ΡΡΠ²Π° ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΡΡΠΈΠ»ΠΌΠ΅ΡΠΈΠ»Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠΏΠΈΡΠΈΠ΄ΠΈΠ½Π°
ΡΡΠΊΡΠΈΠ½Π°Ρ Π² Π΄ΠΎΠ·Π΅ 10 ΠΌΠ³/ΠΊΠ³ Π²Π΅ΡΠ° ΠΆΠΈΠ²ΠΎΡΠ½ΠΎΠ³ΠΎ Π·Π° 30 ΠΌΠΈΠ½ΡΡ Π΄ΠΎ ΠΏΠ»Π°Π²Π°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΡΠ°. Π Π΅Π°Π±ΠΈΠ»ΠΈΡΠΈΡΡΡΡΠΈΠ΅
ΡΠΈΠ·ΠΈΠΎΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΡ Π² Π²ΠΈΠ΄Π΅ ΠΏΠ°Π½ΡΠΎΠ²ΡΡ
Π²Π°Π½Π½ ΠΎΠΊΠ°Π·Π°Π»ΠΈΡΡ Π±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ
ΠΊΠ°ΠΊ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ Π³ΠΎΡΠΌΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ, ΡΠ°ΠΊ ΠΈ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Π΅ΠΉ ΡΠΎΠ»ΡΠΊΠΎ Π² ΡΠ»ΡΡΠ°Π΅ Π΄Π΅ΡΠΈΠ½Ρ
ΡΠΎΠ½ΠΎΠ·Π°,
ΡΠ²ΡΠ·Π°Π½Π½ΠΎΠ³ΠΎ Ρ ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠ²Π΅ΡΠ»ΠΎΠΉ ΡΠ°Π·Ρ ΡΡΡΠΎΠΊ. Π ΠΎΡΠ»ΠΈΡΠΈΠ΅ ΠΎΡ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠΈΡΡΡΡΠΈΡ
ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠ΅
Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΡΠΈΠ»ΠΌΠ΅ΡΠΈΠ»Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠΏΠΈΡΠΈΠ΄ΠΈΠ½Π° ΡΡΠΊΡΠΈΠ½Π°ΡΠ° ΠΏΡΠΎΡΠ²ΠΈΠ»ΠΈΡΡ Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΠΎ ΠΎΡ ΡΠΈΠΏΠ°
Π΄Π΅ΠΏΡΠΈΠ²Π°ΡΠΈΠΉ ΠΈ ΡΠΎΠ»ΡΠΊΠΎ Π½Π° ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΎΠΌ ΡΡΠΎΠ²Π½Π΅, ΡΡΠΎ Π²ΡΡΠ°ΠΆΠ°Π»ΠΎΡΡ Π² ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΎΠ³ΠΎ
ΡΡΠ°ΡΡΡΠ°The present study reports the results of analyzing the adaptive responses of laboratory rats
(n=120, Wistar males) with physical fatigue (after the swimming test) and light desynchronosis during
the autumnal equinox and the possibility of their pharmacological or physiotherapeutic correction.
Rehabilitation procedures were carried out using water and antler baths for 10 days immediately after
exposure to stress factors. The reference agent was ethylmethylhydroxypyridine succinate, which was
injected at a dose of 10 mg/kg of animal weight 30 minutes before the swimming test. Rehabilitation
physiotherapeutic measures in the form of antler baths proved to be more effective both at the hormonal
and behavioral levels only in the case of desynchronosis associated with the extension of the light phase of
the day. In contrast to rehabilitation procedures, preventive measures using ethylmethylhydroxypyridine
succinate were effective regardless of the type of deprivation and only at the behavioral level, resulting
in stabilization of the behavioral stat