der(21)t(1;21)(q11-12;p11-13) and der(21)t(1;21)(q21-32;p11-13)

Unbalanced chromosome translocations involving all or part of the whole long arm of chromosome 1 and the short arms of acrocentric chromosomes are widely reported in human neoplasia. Among them, chromosome translocations between the long arm of chromosome 1 and chromosome 21 have been reported in patients with various conditions, including myeloid malignancies, acute lymphoblastic leukemia, multiple myeloma and lymphomas

der(17)t(17;17)(p13;q12-21)

Rare translocation. Because of its rarity, the clinical significance of der(17)t(17;17)(p13;q12-21) is unknown

t(2;17)(q32;q21) NABP1/RARA

Acute promyelocytic leukemia (APL) is characterized by arrest of leukocyte differentiation at the promyelocyte stage. In classic APL, the central leukemia-initiating event is the chromosome translocation t(15;17)(q22;q21) resulting in the fusion of the retinoic acid receptor-alpha (RARA) gene on 17q21.1 with the promyelocytic leukemia..ML) gene at 15q24.1. In rare cases, RARA is fused with genes other than PML that gives rise to APL variants such as in der(2)t(2;17)(q32;q21) with the underlyin

t(7;14)(p15;q11) TRD/HOXA10

Review on t(7;14)(p15;q11) TRD/HOXA10, with data on clinics

t(11;14)(q11;q32)

Review on t(11;14)(q11;q32), with data on clinics, and the genes involved

t(7;14)(p15;q32)

Rearrangements of T-cell receptor (TCR) genes are characteristic chromosomal abnormalities in a variety of T-cell malignancies, particularly in T-cell lymphoblastic leukemia/lymphomas, but TCR-gamma gene or TCL1A (TCR-T-cell leukemia/lymphoma 1A) rearrangements are rare

t(6;17)(p21;p13)

6p rearrangements in myeloid malignancies are characterized by heterogeneous breakpoints and chromosome abnormalities that involve various partner chromosomes. Balanced chromosome translocations involving 6p21 are infrequent, among them the t(6;17)(p21;p13 has been observed only in sporadic cases

der(4)t(1;4)(q11-32;q34-35)

Unbalanced 1q rearrangements are widely reported in myeloid and lymphoid malignancies. Among unbalanced translocations of 1q, der(4)t(1;4)(q11-32;q34-q35) resulting in complete or partial trisomies of genes located on 1q is a relatively rare anomaly

der(3)t(3;3)(p25-26;q12-21)

Partial or complete chromosome gains are frequently found in hematological malignancies, but the unbalanced der(3)t(3;3) is a relatively rare chromosome anomaly

t(18;21)(p11;q11)

Chromosome translocation between the short arm of chromosome 18 and the long arm of chromosome 21 including the t(18;21)(p11;q11) is a rare event, reported only in sporadic cases