der(21)t(1;21)(q11-12;p11-13) and der(21)t(1;21)(q21-32;p11-13)

Unbalanced chromosome translocations involving all or part of the whole long arm of chromosome 1 and the short arms of acrocentric chromosomes are widely reported in human neoplasia. Among them, chromosome translocations between the long arm of chromosome 1 and chromosome 21 have been reported in patients with various conditions, including myeloid malignancies, acute lymphoblastic leukemia, multiple myeloma and lymphomas

del(5q) in acute lymphoblastic leukemia (ALL)

Myelodysplatic syndrome (MDS) with an isolated 5q deletion (5q-syndrome), that may arise de novo or may be therapy-related is recognized as a distinct entity by the WHO classification. While del(5q) thought to contribute to the pathogenesis of myeloid neoplasms, it has also been reported in lymphoblastic leukemia, suggesting a common underlying mechanism

t(3;4)(p21;q34) as a sole anomaly in acute myeloid leukemia patient

Case report of a translocation : t(3;4)(p21;q34) as a sole anomaly in acute myeloid leukemia patient

der(17)t(17;17)(p13;q12-21)

Rare translocation. Because of its rarity, the clinical significance of der(17)t(17;17)(p13;q12-21) is unknown

t(1;16)(q11-12;q11) presented as a der(16)t(1;16) in a patient with acute lymphoblastic leukemia

Case report of a translocation : t(1;16)(q11-12;q11) presented as a der(16)t(1;16) in a patient with acute lymphoblastic leukemia

t(2;17)(q32;q21) NABP1/RARA

Acute promyelocytic leukemia (APL) is characterized by arrest of leukocyte differentiation at the promyelocyte stage. In classic APL, the central leukemia-initiating event is the chromosome translocation t(15;17)(q22;q21) resulting in the fusion of the retinoic acid receptor-alpha (RARA) gene on 17q21.1 with the promyelocytic leukemia..ML) gene at 15q24.1. In rare cases, RARA is fused with genes other than PML that gives rise to APL variants such as in der(2)t(2;17)(q32;q21) with the underlyin

t(7;14)(p15;q11) TRD/HOXA10

Review on t(7;14)(p15;q11) TRD/HOXA10, with data on clinics

t(11;14)(q11;q32)

Review on t(11;14)(q11;q32), with data on clinics, and the genes involved

t(7;14)(p15;q32)

Rearrangements of T-cell receptor (TCR) genes are characteristic chromosomal abnormalities in a variety of T-cell malignancies, particularly in T-cell lymphoblastic leukemia/lymphomas, but TCR-gamma gene or TCL1A (TCR-T-cell leukemia/lymphoma 1A) rearrangements are rare

der(6)t(1;6)(q21;p21) in myelofibrosis following polycythemia vera

Case report of a translocation : der(6)t(1;6)(q21;p21) in myelofibrosis following polycythemia vera