In Vitro Comparative Degradation Study Between Two Brands Of Amytriptyline Hydrochloride Tablet Using UV Spectrophotometer

Abstract The objective of this study was to develop the degradation studies of different brands of amytriptyline hydrochloride in market. Forced degradation is a process that involves degradation of drug products and drug substances at conditions more severe than accelerated conditions and thus generates degradation products that can be studied to determine the stability of the molecule. Amitriptyline (AMT) belongs to tricyclic dibenzocycloheptadiene derivatives. It acts primarily as a serotonin-norepinephrine reuptake inhibitor, used for the treatment of several psychiatric disorders. This drug was subjected to different stress conditions as per International Conference on Harmonization guidelines (ICH). An ultraviolet UV spectroscopic method was developed for analysis of the drug in the presence of the degradation products. Distilled water was used as a solvents. The amount of degraded drugs was calculated by taking the absorbance at 222 nm. According to the assay limit of USP specified that the content should not be less than 95% and not more than 105% of labelled amount. All brands were degraded on basic pH and on acidic pH. In addition to heat exposure all brands were also degraded. It was concluded that all brands degraded from ranges for all the stresses applied for degradation studies

Effects or Bottom Configurations on Ware-Current Field

An attempt is taken to apprehend the coexistence phenomenon of wave, current and submerged structures numerically. The governing equations of this model are derived by vertical integration of continuity equation and the equation of motion for gradually varying impermeable sea bottom and discretized with a semi-implicit technique, such that, at every time step, the resulted tridiagonal matrix can be solved by the method of double sweep. As an application, this model is applied to study the characteristics of the interacted waves and currents over submerged mounds of parabolic and trapezoidal cross sections. Results show that the change of wave characteristics for both cases are significant over the mounds

Interaction effect of phosphorus and boron on yield and quality of lettuce

Proper nutrition is essential for satisfactory crop growth and production. A field experiment was conducted at Bangabandhu Sheikh Mujibur Rahman Agricultural University, to evaluate yield and quality of Grand Rapids lettuce using various levels of phosphorus and boron. Treatment combination of 120 kg ha-1 of phosphorus and 2 kg ha-1 of boron has significantly increased plant height, leaf number, leaf length, plant canopy, capsules plant-1, seeds capsule-1, seeds number plant-1, seed yield ha-1, germination (%), planting value (%), moisture (%), purity (%), dry matter (%) and 1000 seed weight. Most of the treatment combinations performed better than control treatments in all parameter. The finding could be helpful to determine the precise levels of phosphorus and boron to improve the yield and quality of lettuce