Adverse Events Following COVID-19 Vaccination among the Beneficiaries of Sikkim Manipal University: A Cross Sectional Study

Background: Covid-19, an infection caused by SARS- CoV2 has claimed millions of lives since late 2019 with no curative measures. In India, 4 vaccines have been approved for use i.e. Serum Institute’s Covishield, Bharat Biotech’s Covaxin, GRIEM’s Sputnik V and Moderna’s Covid-19 vaccine. Aims: This study aims to find the adverse events following Covishield vaccination among the beneficiaries of Sikkim Manipal University, Sikkim. Material &Methods: A cross sectional study was conducted among the beneficiaries of Sikkim Manipal University to find out the adverse events following the first dose of vaccination. The data was collected using a self-administered questionnaire when the beneficiaries came for their second dose of vaccination. Microsoft Excel and SPSS version 27 was used for statistical analysis. Results: Out of 716 study participants majority i.e. 79.5% of the study participants developed adverse events following their first dose with maximum (73.8%) complaining of pain at the site of infection followed by fever (65.2%). Conclusions: Vaccines may prevent diseases, but it also brings about adverse effects, be it minor or major. Hence, many studies are required to study their full-fledged side effects and the means to overcome them

Testing and Lockdown; how much & to what extent? - An epidemiological dilemma

Testing and lockdown is the strategy planned to work on reducing the COVID-19 death. there are different views of community transmission and testing strategy. The views of lockdown also have various idea and scenarios which is thought for Pandemic like COVID-19

Glucose indices, frank and undetected diabetes in relation to hypertension and anthropometry in a South Indian rural population

Diabetes has emerged as one of the world′s biggest health problems and its prevalence is increasing at an alarming rate. This study was conducted to find out the magnitude of frank and undetected diabetes mellitus, including impaired glucose tolerance (IGT) among persons in rural Karnataka, and its relationship with associated risk factors like hypertension and anthropometry. This was a population-based, cross-sectional study on 1370 participants in the field practice area of KBN Medical College, conducted from April 2009 to March, 2010. Diabetes mellitus was noted among 19.78% of the participants, with an additional 12.04% with impaired glucose tolerance. Hypertension observed among participants with diabetes and impaired glucose tolerance was 65.13 and 53.94%, respectively. Effective primary prevention strategies have to be intensified among high-risk population groups, to promote awareness through behavior change communication

Assessment of impact of small group teaching among students in community medicine

Background: We conducted a study to assess the impact of small group teaching (SGT) among students by feedback analysis to identify intricacy so that learning can be facilitated. Materials and Methods: This cross-sectional study was undertaken among 182 MBBS students studying at a teaching hospital at Gangtok. Students were provided with a questionnaire following an assignment on a scheduled topic. Students were asked to provide feedback on the modes of teaching-learning practiced in community medicine with the parameters of evaluation including assessment of presentation by faculty member in reference to relevance, sequencing, depth, interaction, etc., to the overall rating of presentations in different teaching-learning methods. Results: The faculty members were on the positive evaluation by the students in the SGT, which was preferred over "lectures" as the teaching-learning methods. Among SGTs "tutorials" were graded better than "practical," "seminar" and "field posting" on the basis of longer duration at a stretch. Among the parameters for evaluation, relevance, depth, and interaction in regard to scheduled topic of presentations, the rating was significantly higher in SGT than different other teaching-learning methods. Largely the students noted that the time devoted and number of hours/sessions allotted for each topic was adequate. Conclusion: All forms of SGT were on the positive appraisal by the students on their learning experience and were considered as a comprehensive tool for in-depth teacher-student interaction

Evaluating ranitidine, pantoprazole and placebo on gastric pH in elective surgery

Background and Aim: Concern about the grim nature of postoperative acid aspiration syndrome grew among the anesthesiologist over the years warranting the need for pre-emptive intervention. The aim of the study is to compare the effects of preoperative oral ranitidine versus pantoprazole given in regulating gastric pH in elective surgery. Methods: This prospective, parallel group, controlled, randomized, single-blind study was conducted at a tertiary care postgraduate teaching institute at Kolkata, involving 120 participants of either sex, aged 18-60 years of American Society of Anesthesiologists physical status I and II, who were scheduled for elective surgery under general anesthesia lasting for more than 2 h. The participants were divided into three groups. In group A (n=40) participants received placebo tablet, in group B (n=40) participants received ranitidine tablet while in group C (n=40), participants received pantoprazole tablet and their gastric pH estimated serially. Results: The participants in the three groups were comparable in terms of age, sex, body weight, duration of surgery and type of surgery distribution. In regard to changes in gastric pH trends, there was no statistically significant difference between serial pH values in group A (Friedman test; P>0.05) and group C participants. (P>0.05). However, the mean preoperative gastric pH values (7.140±.7652) were significantly lower than mean pH values (7.253±.7514) after 2 h postoperatively in group B participants (P<0.05). Conclusion: From the observations and analyses of the present study, it can be inferred that ranitidine is more effective than pantoprazole to raise the gastric pH for prevention of aspiration pneumonitis

The Impact of Body Resistance Training Exercise on Biomedical Profile at High Altitude: A Randomized Controlled Trial

Background. Obesity causes different diseases, eventually. In our study, the results of resistance exercises were examined on selected biochemical markers in Abha City, Saudi Arabia, which is at the height of 2,270 meters above sea level. Methods. A randomized controlled research was conducted with 60 participants equally divided into three groups, 20 subjects in each group: group 1 was composed of obese people who received resistance training exercise, group 2 was composed of the obese control group who did not receive resistance training exercise, and group 3 was composed of normal individuals who received resistance exercise training. The resistance exercises were done in the 6th and 12th weeks. Biochemical blood tests were done. Results. Comparing to the control group, glucose decreased very little with insulin also showing little difference. It has been seen that TC, TG, and LDL reduced to a reasonable extent after resistance exercise, while HDL was increased (p≤0.01). Plasma urea and creatinine showed no differences. Interleukin-6 and leptin decreased significantly (p≤0.01), while there was a significant elevation in adiponectin and testosterone (p≤0.01) once comparing group 1 with group 2 and group 3. Conclusion. We have seen that resistance exercise helps in reducing lipid profile which will result in a decrease of the cardiac and related risk factors when conducted in obese patients in high-altitude regions. Also, alterations of the levels of interleukin-6, leptin, adiponectin, and testosterone showed that resistance exercise is of benefit and favourable in obese persons in high-altitude regions, which can also pave the way for added development of drugs related to the above parameters