An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbances

<p>Abstract</p> <p>Backgrounds</p> <p>B3 adrenoreceptors (ADRB3) are abundant in adipose tissue and play the role in its metabolism and lipolysis. Some variants of the ADRB3 gene may predispose subjects for the development obesity and metabolic abnormalities in the setting of modern sedentary lifestyle. ADRB3 gene polymorphism association with metabolic disturbances has never been studied before in the ethnic Kyrgyz population.</p> <p>Aim</p> <p>To study an association between Trp64Arg polymorphism of the ADRB3 and metabolic syndrome (MS) components in an ethnic Kyrgyz group.</p> <p>Materials and methods</p> <p>213 Ethnic Kyrgyz volunteers over the age of 30 were enrolled in the study. The assessment plan for each individual comprised of general physical and anthropometric exams as well as laboratory tests (glucose, lipid panel, insulin) and genotyping by Trp64Arg polymorphism of the ADRB3. MS diagnosis was consistent with modified ATP III criteria (2005). Logistic regression analysis was performed to test the potential independent association between Arg64 allele with obesity, abdominal obesity (AO) and arterial hypertension (AH).</p> <p>Results</p> <p>Trp64Arg polymorphism of the ADRB3 was assessed in 213 individuals (145 men, 68 women) aged 30-73 (mean age 50.7 ± 7.6). Arg64 allele frequency was 0.239; ADRB3 genotype distribution among participants was: Trp64 homozygotes 54.5%, Trp64Arg 43.2% and Arg64 homozygotes 2.3%. There was an association between Trp64Arg и Arg64Arg genotypes and higher BMI, WC and obesity frequency (p < 0.00009), AO (p < 0.01), type 2 diabetes mellitus (DM) (p < 0.005) and lower high density cholesterol (HDL-C) level (p < 0.03). The logistic regression analysis showed the correlation of the Arg64 allele with obesity (OR 3.159; 95% CI 1.789-5.577) and AO (OR 1.973; 95% CI 1.118-3.481). The association between Arg64 allele and AH lost its significance after adjustment for obesity.</p> <p>Conclusion</p> <p>Arg64 allele of the ADRB3 gene in the studied group has an association with MS components such as obesity, AO and decreased HDL-C level.</p

INSCRIPTION PROCESS RESEARCH AND OPTIMIZATION FOR SUPERIMPOSED FIBER BRAGG GRATINGS

Subject of Research. The paper presents the study of inscription process distinctive features for superimposed fiber Bragg gratings. We analyzed spectral characteristics changes of superposition segregated gratings that appear during inscription of subsequent diffraction structures over the first ones. Method. Superimposed fiber Bragg gratings inscription was carried out by means of Talbot interferometer. Excimer laser system Optosystems MOPA CL-7550 was used as a radiation source. It was operating on gas mixture KrF (radiation wavelength is equal to 248 nm). The phase mask with a 1000 nm period was implemented in the inscription scheme for laser beam amplitude separation. Fiber Bragg gratings were inscribed in anisotropic optical fiber with 12 mol.% of GeO2 in optical fiber core. Main Results. Samples of superimposed fiber Bragg gratings were obtained and their spectral characteristics were analyzed. We have studied the regularities of the change in the reflection coefficient and the central wavelength of the first grating of the superposition from the number of diffraction structures inscribed over it, the exposure time during the inscription, and the spectral interval between them. Based on the results obtained, recommendations are given for optimizing the superimposed fiber Bragg gratings inscription process. Practical Relevance. The obtained superimposed fiber Bragg gratings can be used in the manufacture of optical filters, sensors for simultaneous measurement of several parameters, as well as for multiplexing and demultiplexing signals in telecommunications