Modification of the low-latitude ionosphere before the 26 December 2004 Indonesian earthquake

International audienceThis paper investigates the features of pre-earthquake ionospheric anomalies in the total electron content (TEC) data obtained on the basis of regular GPS observations from the IGS network. For the analysis of the ionospheric effects of the 26 December 2004 Indonesian earthquake, global TEC maps were used. The possible influence of the earthquake preparation processes on the main low-latitude ionosphere peculiarity ? the equatorial anomaly ? is discussed. Analysis of the TEC maps has shown that modification of the equatorial anomaly occurred a few days before the earthquake. For 2 days prior to the event, a positive effect was observed in the daytime amplification of the equatorial anomaly. Maximal enhancement in the crests reached 20 TECU (50?60%) relative to the non-disturbed state. In previous days, during the evening and night hours (local time), a specific transformation of the TEC distribution had taken place. This modification took the shape of a double-crest structure with a trough near the epicenter, though usually in this time the restored normal latitudinal distribution with a maximum near the magnetic equator is observed. It is assumed that anomalous electric field generated in the earthquake preparation zone could cause a near-natural "fountain-effect" phenomenon and might be a possible cause of the observed ionospheric anomaly

Comparative Study of foF2 Measurements with IRI-2007 Model Predictions During Extended Solar Minimum

The unusually deep and extended solar minimum of cycle 2324 made it very difficult to predict the solar indices 1 or 2 years into the future. Most of the predictions were proven wrong by the actual observed indices. IRI gets its solar, magnetic, and ionospheric indices from an indices file that is updated twice a year. In recent years, due to the unusual solar minimum, predictions had to be corrected downward with every new indices update. In this paper we analyse how much the uncertainties in the predictability of solar activity indices affect the IRI outcome and how the IRI values calculated with predicted and observed indices compared to the actual measurements.Monthly median values of F2 layer critical frequency (foF2) derived from the ionosonde measurements at the mid-latitude ionospheric station Juliusruh were compared with the International Reference Ionosphere (IRI-2007) model predictions. The analysis found that IRIprovides reliable results that compare well with actual measurements, when the definite (observed and adjusted) indices of solar activityare used, while IRI values based on earlier predictions of these indices noticeably overestimated the measurements during the solar minimum.One of the principal objectives of this paper is to direct attention of IRI users to update their solar activity indices files regularly.Use of an older index file can lead to serious IRI overestimations of F-region electron density during the recent extended solar minimum

Dynamic Algorithms of Multilayered Neural Networks Training in Generalized Training Plant

The new modifications of multilayered neurak networks training algorithms in a generalized training plant structure are introduced. The first modification for algorithm "on error backpropagation algorithm through time" is introduced and its sufficient conditions of a training procedure stability are obtained. Other modification for speed gradient algorithm of an error backpropagation is obtained, where measurement state vector in a training procedure instead of a parametrical model of plant is used

Natural Phaeosphaeride A Derivatives Overcome Drug Resistance of Tumor Cells and Modulate Signaling Pathways

n the present study, natural phaeosphaeride A (PPA) derivatives are synthesized. Anti-tumor studies are carried out on the PC3, K562, HCT-116, THP-1, MCF-7, A549, NCI-H929, Jurkat, and RPMI8226 tumor cell lines, and on the human embryonic kidney (HEK293) cell line. All the compounds synthesized turned out to have better efficacy than PPA towards the tumor cell lines listed. Among them, three compounds exhibited an ability to overcome the drug resistance of tumor cells associated with the overexpression of the P-glycoprotein by modulating the work of this transporter. Luminex xMAP technology was used to assess the effect of five synthesized compounds on the activation of intracellular kinase cascades in A431 cells. MILLIPLEX MAP Multi-Pathway Magnetic Bead 9-Plex was used, which allowed for the simultaneous detection of the following nine phosphorylated protein markers of the main intracellular signaling pathways: a universal transcription factor that controls the expression of immune-response genes, apoptosis and cell cycle NFκB (pS536); cAMP-dependent transcription factor (CREB (pS133); mitogen-activated kinase p38 (pT180/pY182); stress-activated protein kinase JNK (pT183/pY185); ribosomal SK; transcription factors STAT3 (pS727) and STAT5A/B (pY694/699); protein kinase B (Akt) (pS473); and kinase regulated by extracellular signals ERK1/2 (pT185/pY187). The effect of various concentrations of PPA derivatives on the cell culture was studied using xCelligence RTCA equipment. The compounds were found to modulate JNK, ERK1/2, and p38 signaling pathways. The set of activated kinase cascades suggests that oxidative stress is the main probable mechanism of the toxic action of PPA derivatives

A combined estimator using TEC and b-value for large earthquake prediction

[EN] Ionospheric anomalies have been shown to occur a few days before several large earthquakes. The published works normally address examples limited in time (a single event or few of them) or space (a particular geographic area), so that a clear method based on these anomalies which consistently yields the place and magnitude of the forthcoming earthquake, anytime and anywhere on earth, has not been presented so far. The current research is aimed at prediction of large earthquakes, that is with magnitude M-w 7 or higher. It uses as data bank all significant earthquakes occurred worldwide in the period from January 1, 2011 to December 31, 2018. The first purpose of the research is to improve the use of ionospheric anomalies in the form of TEC grids for earthquake prediction. A space-time TEC variation estimator especially designed for earthquake prediction will show the advantages with respect to the use of simple TEC values. 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Spatial and Temporal Evolution of Different‐Scale Ionospheric Irregularities in Central and East Siberia During the 27–28 May 2017 Geomagnetic Storm

We present a multi-instrumental study of ionospheric irregularities of different scales (from tens of centimeters to few kilometers) observed over the Central and East Siberia, Russia, during a moderate-to-strong geomagnetic storm on 27–28 May 2017. From high-frequency (HF) and ultrahigh-frequency (UHF) radar data, we observed an intense auroral backscatter developed right after the initial phase of the geomagnetic storm. Additionally, we examined variations of Global Positioning System (GPS)-based ROT (rate of TEC changes, where TEC is total electron content) for available GPS receivers in the region. Ionosondes, HF, and UHF radar data exhibited a presence of intense multi-scale ionospheric irregularities. We revealed a correlation between different-scale Auroral/Farley-Buneman ionospheric irregularities of the E layer during the geomagnetic storm. The combined analysis showed that an area of intense irregularities is well connected and located slightly equatorward to field-aligned currents (FACs) and auroral oval at different stages of the geomagnetic storm. An increase and equatorward displacement of Region 1 (R1)/Region 2 (R2) FACs leads to appearance and equatorward expansion of ionospheric irregularities. During downward (upward) R1 FAC and upward (downward) R2 FAC, the eastward and upward (westward and downward) E × B drift of ionospheric irregularities occurred. Simultaneous disappearance of UHF/HF auroral backscatter and GPS ROT decrease occurred during a prolonged near noon reversal of R1 and R2 FAC directions that accompanied by R1/R2 FAC degradation and disappearance of high-energy auroral precipitation