1 research outputs found
The Leptin concentrations in seminal plasma of men and its relationship to semen parameters
Background: Leptin is a polypeptide hormone secreted by white adipose
tissue in proportion to body energy. Although the participation of
leptin in female reproduction is well established, any role in male
reproductive function is at best tenuous. Objective: The objective of
this study was to compare the leptin concentration in human seminal
plasma and then the relationships between seminal leptin and semen
parameters were evaluated. Materials and Methods: Semen samples were
provided from 71 men; normozoospermic (n=22), asthenozoospermic (n=31)
and oligoasthenozoospermic (n=18) referring to Jichi Medical University
Hospital for in vitro fertilization-embryo transfer (IVF-ET) treatment.
After liquefaction, all sperm specimens were evaluated for sperm
parameters and motility characteristics by computer-assisted semen
analysis (CASA) system. After semen analysis, concentrations of leptin
in seminal plasma of all groups were measured by ELISA. Results: The
mean concentrations of leptin in seminal plasma of normozoospermic,
asthenozoospermic and oligoasthenozoospermic men were 0.75+/-0.09
ng/ml, 0.8+/-0.14 ng/ml and 0.8+/-0.15 ng/ml, respectively. A trend was
observed for a lower leptin concentration in seminal plasma of
normozoospermic men compared with asthenozoospermic and
oligoasthenozoospermic men. There was a significant negative
correlation between seminal plasma leptin concentration with sperm
motility (p<0.05) and Curvilinear Velocity of the sperm kinetic
parameter (p<0.01). Conclusion: It was demonstrated that there was a
significant correlation between seminal leptin with the sperm motility