2 research outputs found
Relationship between Occurrence of Guillan-Barre Syndrome and Mass Campaign of Measles and Rubella Immunization in Iranian 5-14 Years Old Children
Objective:Several case reports and epidemiologic studies have reported
a relation between different vaccines including measles, rubella, and
mumps and Guillain-Barre syndrome (GBS). In this study we investigated
relation between receiving measles and/or rubella vaccines and
occurrence of Guillain- Barre syndrome after national immunization
campaign in 2003 in Iran. Material & Methods: In this study we used
National Surveillance system for acute flaccid paralysis data from the
beginning of 2002 to the end of 2004. We studied 5-14 year-old
children. Three-year time span of the study was divided into fifteen 10
weeks periods, and number of reported and approved cases of
Guillain-Barre syndrome in each time period has been analyzed supposing
their distribution was according to Poisson distribution. One of time
periods has been chosen in a manner that its first 4 weeks included
embedded National Immunization and following 6 weeks were designated
for covering incubation period of Guillin- Barre syndrome. Findings: Of
total 553 reported flaccid paralysis cases in 5-15 year-old children
370 were approved to be Guillain- Barre (~67%). Estimated average
incidence of Guillain-Barre syndrome in <15 year-olds is
1/100,000/year (95% CI: 0.88-13), and in 5-15 year-old children is
0.6/100,000/year (95% CI: 0.58-083). Thus, number of expected cases in
25 cases each 10 weeks time period was 23.8 of GBS that were reported
in the time period which coincided with immunization campaign.
Probability of occurring ≥25 cases of GBS in that time period
according to Poison distribution with expected case numbers of 23.8 is
equal to 0.43 (P=0.43). Conclusion:Yearly incidence rate of GBS in this
study was similar to other studies. According to our results, there was
no increase in GBS incidence in the 4 weeks national Immunization
Campaign and 6 weeks after it in comparison to other 10 weeks periods
before or after this time period