Evaluation of levothyroxine effect on pulmonary function inhypothyroidism

(Received 14 Jul, 2008; Accepted 12 Nov, 2008) Abstract Background and purpose: Hypothyroidism is one of the most common diseases in endocrinology Thyroid hormone deficiency effects on nerve and muscle fibers, pulmonary system and alveolar ventilation. The aim of this study was to evaluate the effect of Levothyroxine therapy on pulmonary function in hypothyroidism patients in Imam Hospital.Materials and methods: This study was performed on 50 patients with hypothyroidism in Imam Hospital, Sari, Iran, 2006-2007. After a detailed clinical history and systemic examination, level of TSH, T4 and ABG test, chest radiography and spirometery was performed in all patients. The spirometery indexes including FVC, FEV1, FEV1/FVC, FEF 25-75, PEF were recorded. All patients treated with Levothyroxine 1.6μg/kg. After that all systemic and clinical examination, and chest radiography and spirometery performed again. Results analyzed by means of SPSS (11) software and paired t test. The p value less than 0.05 was considered to be significant statisticallyResults: 50 female patients, with mean age of 34.98±13.4 years were studied. The mean of TSH, T4 before treatment were 51.44±25.3 mIu/l and 2.8± 0.9 μg/dl and after treatment were 3.64±2.4 mIu/l and 9.80±4.9 μg/dl respectively (P= 0.0001). The ABG parameters were in normal range and there was no statistically significant difference between before and after treatment. Statistical analysis demonstrated significant differences between mean of FVC, FEV1, FEV1/FVC, FEF 25-75, and PEF before and after treatment.Conclusion: Our study demonstrates that treatment of hypothyroidism with Levothyroxine can improves the pulmonary function according to spirometery findings

Evaluation the posture of bank employees by using two methods RULA and OCRA

Bank employees are at risk of musculoskeletal problems because of the physical and mental requirements of the job. Studies show that more than 60 percent of bank employees have been directly or indirectly involved in many factors, such as personal characteristics, conditions and workstations, stress and repetitive movements. The aim of this study was to evaluate the RULA and OCRA methods of risk factors for musculoskeletal disorders in the bank staff. This study was carried out in order to assess the physical status of 80 the bank employees using two methods: RULA and OCRA. According to the results, the average score RULA and OCRA are 4.13±1.14 and 0.300±0.088, respectively. Statistically significant t - tests show differences between RULA and OCRA assessment methods. The RULA scores for the three age groups were also not significantly different, as they also apply to the OCRA score. Though, there are similarities between the two methods especially in assessment of repetitive motion in upper limb, but OCRA method propose as appropriate method to MSDs risk evaluate, so is not recommended to use two method instead of each other