Immediate effect of kinesiology tape on ankle stability

BackgroundLateral ankle sprain is one of the most common musculoskeletal injuries, particularly among the sporting population. Due to such prevalence, many interventions have been tried to prevent initial, or further, ankle sprains. Current research shows that the use of traditional athletic tape can reduce the incidence of sprain recurrence, but this may be at a cost to athletic performance through restriction of motion. Kinesiology tape, which has become increasingly popular, is elastic in nature, and it is proposed by the manufacturers that it can correct ligament damage. Kinesiology tape, therefore, may be able to improve stability and reduce ankle sprain occurrence while overcoming the problems of traditional tape.AimTo assess the effect of kinesiology tape on ankle stability.Methods27 healthy individuals were recruited, and electromyography (EMG) measurements were recorded from the peroneus longus and tibialis anterior muscles. Recordings were taken from the muscles of the dominant leg during induced sudden ankle inversion perturbations using a custom-made tilting platform system. This was performed with and without using kinesiology tape and shoes, creating four different test conditions: barefoot(without tape), shoe(without tape), barefoot(with tape) and shoe(with tape). For each test condition, the peak muscle activity, average muscle activity and the muscle latency were calculated.ResultsNo significant difference (p>0.05) was found by using the kinesiology tape on any of the measured variables while the wearing of shoes significantly increased all the variables.ConclusionKinesiology tape has no effect on ankle stability and is unable to nullify the detrimental effects that shoes appear to have

Anti-α-Internexin Autoantibody from Neuropsychiatric Lupus Induce Cognitive Damage via Inhibiting Axonal Elongation and Promote Neuron Apoptosis

Neuropsychiatric systemic lupus erythematosus (NPSLE) is a major complication for lupus patients, which often leads to cognitive disturbances and memory loss and contributes to a significant patient morbidity and mortality. The presence of anti-neuronal autoantibodies (aAbs) has been identified; as examples, anti-NMDA receptors and anti-Ribsomal P aAbs have been linked to certain pathophysiological features of NPSLE.In the current study, we used a proteomic approach to identify an intermediate neurofilament alpha-internexin (INA) as a pathogenetically relevant autoantigen in NPSLE. The significance of this finding was then validated in an expanded of a cohort of NPSLE patients (n = 67) and controls (n = 270) by demonstrating that high titers of anti-INA aAb was found in both the serum and cerebrospinal fluid (CSF) of ∼50% NPSLE. Subsequently, a murine model was developed by INA immunization that resulted in pronounced cognitive dysfunction that mimicked features of NPSLE. Histopathology in affected animals displayed cortical and hippocampal neuron apoptosis. In vitro studies further demonstrated that anti-INA Ab mediated neuronal damage via inhibiting axonal elongation and eventually driving the cells to apoptosis.Taken together, this study identified a novel anti-neurofilament aAb in NPSLE, and established a hitherto undescribed mechanism of aAb-mediated neuron damage that could have relevance to the pathophysiology of NPSLE

Testimony of Arnold M. Zack Before the Commission on the Future of Worker-Management Relations

Testimony_Zack_092994.pdf: 137 downloads, before Oct. 1, 2020

MSU 4 Paws: Training Service Dogs

An audio recording discussing the service dog training workshop titled MSU 4 Paws conducted at Morehead State University by Lacy Wallace

Forensisch-medizinische Untersuchungen von Tatverdächtigen. Eine Analyse von 270 Gutachten aus den Jahren 2006 bis 2018

<jats:title>Zusammenfassung</jats:title><jats:sec> <jats:title>Hintergrund</jats:title> <jats:p>Zu den Aufgaben in der rechtsmedizinischen Praxis gehören zunehmend forensisch-medizinische Untersuchungen von Lebenden. Im Gegensatz zu Studien über Gewaltopfer findet sich in der Fachliteratur allerdings ein erhebliches Defizit an Ergebnissen über systematische rechtsmedizinische Untersuchungen von Tatverdächtigen.</jats:p> </jats:sec><jats:sec> <jats:title>Fragestellung</jats:title> <jats:p>Welche relevanten Daten können aus einer retrospektiven Analyse von forensisch-medizinischen Untersuchungen von Tatverdächtigen erhoben und welche Rückschlüsse für die rechtsmedizinische Praxis gezogen werden?</jats:p> </jats:sec><jats:sec> <jats:title>Material und Methode</jats:title> <jats:p>Es wurden insgesamt 270 Gutachten nach forensisch-medizinischen Untersuchungen von Tatverdächtigen aus dem Einzugsgebiet des Instituts für Rechtsmedizin der Universitätsmedizin Rostock der Jahre 2006 bis 2018 nach vorab definierten Kriterien ausgewertet.</jats:p> </jats:sec><jats:sec> <jats:title>Ergebnisse</jats:title> <jats:p>Die vorgeworfenen Straftaten waren am häufigsten Körperverletzungen (<jats:italic>n</jats:italic> = 88 = 30,7 %), gefolgt von vorsätzlichen Tötungen (<jats:italic>n</jats:italic> = 63 = 22,0 %) und Sexualdelikten (<jats:italic>n</jats:italic> = 49 = 17,1 %). Von den begutachteten Personen waren 236 (87,4 %) männlich und 34 (12,6 %) weiblich. Die Mehrzahl der Tatverdächtigen (<jats:italic>n</jats:italic> = 175 = 65,5 %) war in einem Lebensalter von 18 bis 40 Jahren.</jats:p> <jats:p>Im Hinblick auf die Aussage der rechtsmedizinischen Ergebnisse in Bezug auf den vorgeworfenen Straftatbestand wurden 126 (46,7 %) Gutachten als für den Tatverdächtigen belastend, 13 (4,8 %) als entlastend und 131 (48,5 %) als frei von Be- oder Entlastungsaussagen eingestuft.</jats:p> <jats:p>Zu den 270 Gutachten über Tatverdächtige gab es 209 (77,4 %) korrespondierende Opferuntersuchungen. Von diesem Teilkollektiv mit Täter-Opfer-Begutachtungen wurden in 193 Fällen (92,3 %) Tatverdächtige und Opfer von demselben Gutachter untersucht.</jats:p> </jats:sec><jats:sec> <jats:title>Schlussfolgerungen</jats:title> <jats:p>Für die Rekonstruktion eines Tatgeschehens sind rechtsmedizinische Untersuchungen des Opfers und des Tatverdächtigen wertvoller als die nicht selten beobachtete Untersuchung der geschädigten Person allein. Befunde mit belastenden Tendenzen für den Tatverdächtigen werden häufiger festgestellt als solche, die zu einer Entlastung des Beschuldigten führen. Da es in der Fachliteratur im Vergleich zu den Opfern von Gewalttaten ein Defizit an Ergebnissen über systematische forensisch-medizinische Untersuchungen von Tatverdächtigen gibt, sollten weitere Studien folgen.</jats:p> </jats:sec&gt

Dose Range Evaluation of Mycograb C28Y Variant (MYC123 C28Y), a Human Recombinant Antibody Fragment to Heat Shock Protein 90, In Combination with Amphotericin B-Desoxycholate for the Treatment of Murine Systemic Candidiasis

Systemic candidiasis causes significant mortality in patients despite amphotericin B (AMB) therapy. Mycograb C28Y variant, a human recombinant antibody fragment to heat shock protein-90, is closely related to Mycograb, which showed a survival advantage in combination with AMB in a phase 3 human trial. The Mycograb C28Y variant could potentially increase the antifungal effect of AMB. Method: The interaction between AMB-desoxycholate (DAMB) and the Mycograb C28Y variant was characterized in vitro by a checkerboard method. Quantitative cultures of kidneys, livers, and spleens of neutropenic mice with systemic Candida albicans infections were used to assess the in vivo interaction between 1.4 mg/kg/d of DAMB and 0.15, 1.5, and 15 mg/kg/d of the Mycograb C28Y variant after 1, 3, and 5 days of therapy. DAMB and Mycograb C28Y variant monotherapies, vehicle, and a no-treatment arm served as controls. Also, single- and multi-dose pharmacokinetics for the Mycograb C28Y variant were determined. Results: Indifference or synergy between DAMB and the Mycograb C28Y variant was seen in two trials by the checkerboard method. The pharmacokinetics of the Mycograb C28Y variant was best described by a 2-compartment model with a median serum t1/2α of ~0.198 h and a t1/2β of ~1.77 h. In mice, DAMB together with the Mycograb C28Y variant was no more effective than AMB alone (p > 0.05 by ANOVA). The Mycograb C28Y variant alone had no antifungal activity. Conclusion: The Mycograb C28Y variant in combination with DAMB offered no benefit over DAMB monotherapy in a neutropenic murine model of systemic candidiasis