Decreased atherosclerosis in <i>gld.apoE−/−</i> mice treated with MMF.

<p>Aortic root atherosclerotic lesion area in MMF-treated or control mice. <i>A,</i> Representative photographs of aortic root stained with Oil Red O from mice maintained on Western diet for 12 wk and treated with 200 mg/kg/day MMF or untreated. <i>B,</i> Atherosclerotic lesion area of Oil Red O-stained aortae was quantified in both groups (*, <i>p = </i>0.02). <i>C</i>, Total serum cholesterol was quantified in control mice and mice treated with 200 mg/kg/day MMF.</p

Total food intake and average body weights.

<p><i>A</i>, Food was weighed weekly and total amount ingested was recorded for each group (control, n = 8; MMF, n = 9). <i>B,</i> Evolution of body weight as weighed weekly during the course of the experiment.</p

Renal disease is ameliorated in <i>gld.apoE−/−</i> mice after MMF treatment.

<p>The mice were treated with MMF or control for 12 wk. <i>A,</i> Representative H&E-stained sections of kidney in both groups. Glomerular tuft size (<i>B</i>) (*, <i>p = </i>0.002) and cell count (<i>C</i>) (**, <i>p = </i>0.004) were measured by computer-assisted pixel counting. Values shown are the mean ± SEM.</p

MMF treatment decreases the autoimmune phenotype in <i>gld.apoE−/−</i> mice.

<p><i>A,</i> Spleen from mice, treated with 200 mg/kg/day MMF or untreated, was harvested and weighed (*, <i>p</i><0.05). <i>B,</i> The lymph nodes were also harvested and weighed. <i>C,</i> ANA titer was determined from serum samples using HEp-2-coated slides and scored using the value of the last positive dilution (**, <i>p = </i>0.001). Data are expressed as means ± SEM.</p