15 research outputs found
New kidney immobilization method for percutaneous renal biopsy technique in cats: Operational aspects and complications
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Pretreatment and enzymatic process modification strategies to improve efficiency of sugar production from sugarcane bagasse
Get PDFPretreatment of Japanese cedar by ionic liquid solutions in combination with acid and metal ion and its application to high solid loading
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Digital Technology to Deliver a Lifestyle-Integrated Exercise Intervention in Young Seniors—The PreventIT Feasibility Randomized Controlled Trial
No full text10.3389/fdgth.2020.00010Frontiers in Digital Health210
Sequential Targeting of Xylose and Glucose Conversion in Fed-Batch Simultaneous Saccharification and Co-fermentation of Steam-Pretreated Wheat Straw for Improved Xylose Conversion to Ethanol
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PIN1 in breast development and cancer: a clinical perspective
No full textMammary gland development, various stages of mammary tumorigenesis and breast cancer progression have the peptidyl-prolyl cis/trans isomerase PIN1 at their centerpiece, in virtue of the ability of this unique enzyme to fine-tune the dynamic crosstalk between multiple molecular pathways. PIN1 exerts its action by inducing conformational and functional changes on key cellular proteins, following proline-directed phosphorylation. Through this post-phosphorylation signal transduction mechanism, PIN1 controls the extent and direction of the cellular response to a variety of inputs, in physiology and disease. This review discusses PIN1's roles in normal mammary development and cancerous progression, as well as the clinical impact of targeting this enzyme in breast cancer patients
