6 research outputs found
The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation
- Author
- Achim Temme
- Allan C
- Angela Huebner
- Arnaoutov A.
- Asteriti IA
- Asteriti IA
- Babu JR
- Bakhoum SF
- Bayliss R
- Belgareh N
- Bird AW
- Blower MD
- Boisvert FM
- Bowman SK
- Chatel G
- Cheeseman LP
- Chen H
- Ciciarello M
- Compton DA
- Conduit PT
- Cronshaw JM
- Cronshaw JM
- Dodson CA
- Dodson CA
- Eric R. Griffis
- Eyers PA
- Eyers PA
- Goodman B
- Goodwin SS
- Goshima G
- Griffis ER
- Handschug K
- Hirano M
- Hirota T
- Hochegger H
- Huebner A
- Hutterer A
- Itoh G
- Jang CY
- Jeganathan KB
- Joseph J
- Joukov V
- Joukov V
- Joukov V
- Kalab P
- Katrin Koehler
- Kettenbach AN
- Kind B
- Kind B
- King JM
- Kiriyama T
- Krumbholz M
- Lee SH
- Lince-Faria M
- Lioutas A
- Littlepage LE
- Merdes A
- Merdes A
- Meunier S
- Miguel Arocena
- Mishra RK
- Olsen JV
- Otsu N
- Pinyol R
- Poser I
- Prasad R
- Reboutier D
- Rogers SL
- Rome P
- Samora CP
- Sara Carvalhal
- Sardon T
- Satinover DL
- Schweizer N
- Sdelci S
- Silk AD
- Sillje HH
- Storr HL
- Susana Abreu Ribeiro
- Taciana Kasciukovic
- Toughiri R
- Tsai CY
- Tsai MY
- Tsai MY
- Wang LH
- Yixian Zheng
- Zeng K
- Zhao ZS
- Zheng Y
- Zorba A
- Publication venue
- 'American Society for Cell Biology (ASCB)'
- Publication date
- 05/08/2015
- Field of study
The formation of the mitotic spindle is a complex process that requires massive cellular reorganization. Regulation by mitotic kinases controls this entire process. One of these mitotic controllers is Aurora A kinase, which is itself highly regulated. In this study, we show that the nuclear pore protein ALADIN is a novel spatial regulator of Aurora A. Without ALADIN, Aurora A spreads from centrosomes onto spindle microtubules, which affects the distribution of a subset of microtubule regulators and slows spindle assembly and chromosome alignment. ALADIN interacts with inactive Aurora A and is recruited to the spindle pole after Aurora A inhibition. Of interest, mutations in ALADIN cause triple A syndrome. We find that some of the mitotic phenotypes that we observe after ALADIN depletion also occur in cells from triple A syndrome patients, which raises the possibility that mitotic errors may underlie part of the etiology of this syndrome
Long-term risks and benefits associated with cesarean delivery for mother, baby, and subsequent pregnancies: Systematic review and meta-analysis
- Author
- A Maitra
- A Werner
- AA Mamun
- AA Moraitis
- AC van Berkel
- AK Daltveit
- AL Ponsonby
- AM Galyean
- AM Menezes
- AP Betran
- B Xu
- B Xu
- C Almqvist
- C Elvander
- C Fussing-Clausen
- C MacArthur
- C MacArthur
- C Osborne
- C Roduit
- CC Liang
- CM Schooling
- CR Cardwell
- CS Algert
- CV Ananth
- D Fenner
- D Gartland
- D Getahun
- DF Stroup
- DJ Murphy
- E Hemminki
- E Schytt
- EA McDonald
- EH Adlercreutz
- EK Bjelland
- EV Asztalos
- FA van Nimwegen
- FC Barros
- G Rortveit
- GC Smith
- GC Smith
- H Whyte
- H Woolhouse
- HA Goldani
- HM Salihu
- HM Salihu
- HS Downes KL
- HT Li
- HT Li
- I Gurol-Urganci
- I Gurol-Urganci
- J Kero
- J Koplin
- J Mollison
- Jane E. Norman
- Jenny E. Myers
- JZ Press
- K Darmasseelane
- K Negele
- K Pyrhonen
- KH Kjerulff
- LC Stene
- LK Taylor
- M Abdel-Fattah
- M Black
- M Eggesbo
- M Eggesbo
- M Eggesbø
- M Gyhagen
- M Gyhagen
- M Gyhagen
- M Lydon-Rochelle
- M Steur
- MC Magnus
- MC Tollanes
- MC Tollanes
- ME Hannah
- MH Hall
- MZ Goldani
- Oonagh E. Keag
- P Bager
- P Bager
- Q Yang
- R Davidson
- R Gray
- R Kennare
- S Jackson
- S Rasmussen
- S Thavagnanam
- Sarah J. Stock
- SE Roberts
- SE Roberts
- SJ Brown
- SL Lin
- SL Lin
- SL Wood
- SM O'Neill
- SM O'Neill
- SM O'Neill
- SM O'Neill
- SRA Huttly
- SY Huh
- SY Kim
- TA Ajslev
- TM McKeever
- V Andersen
- X Huang
- Y Changzheng
- Z Pei
- ZS SK Bowman
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND:Cesarean birth rates continue to rise worldwide with recent (2016) reported rates of 24.5% in Western Europe, 32% in North America, and 41% in South America. The objective of this systematic review is to describe the long-term risks and benefits of cesarean delivery for mother, baby, and subsequent pregnancies. The primary maternal outcome was pelvic floor dysfunction, the primary baby outcome was asthma, and the primary subsequent pregnancy outcome was perinatal death. METHODS AND FINDINGS:Medline, Embase, Cochrane, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases were systematically searched for published studies in human subjects (last search 25 May 2017), supplemented by manual searches. Included studies were randomized controlled trials (RCTs) and large (more than 1,000 participants) prospective cohort studies with greater than or equal to one-year follow-up comparing outcomes of women delivering by cesarean delivery and by vaginal delivery. Two assessors screened 30,327 abstracts. Studies were graded for risk of bias by two assessors using the Scottish Intercollegiate Guideline Network (SIGN) Methodology Checklist and the Risk of Bias Assessment tool for Non-Randomized Studies. Results were pooled in fixed effects meta-analyses or in random effects models when significant heterogeneity was present (I2 ≥ 40%). One RCT and 79 cohort studies (all from high income countries) were included, involving 29,928,274 participants. Compared to vaginal delivery, cesarean delivery was associated with decreased risk of urinary incontinence, odds ratio (OR) 0.56 (95% CI 0.47 to 0.66; n = 58,900; 8 studies) and pelvic organ prolapse (OR 0.29, 0.17 to 0.51; n = 39,208; 2 studies). Children delivered by cesarean delivery had increased risk of asthma up to the age of 12 years (OR 1.21, 1.11 to 1.32; n = 887,960; 13 studies) and obesity up to the age of 5 years (OR 1.59, 1.33 to 1.90; n = 64,113; 6 studies). Pregnancy after cesarean delivery was associated with increased risk of miscarriage (OR 1.17, 1.03 to 1.32; n = 151,412; 4 studies) and stillbirth (OR 1.27, 1.15 to 1.40; n = 703,562; 8 studies), but not perinatal mortality (OR 1.11, 0.89 to 1.39; n = 91,429; 2 studies). Pregnancy following cesarean delivery was associated with increased risk of placenta previa (OR 1.74, 1.62 to 1.87; n = 7,101,692; 10 studies), placenta accreta (OR 2.95, 1.32 to 6.60; n = 705,108; 3 studies), and placental abruption (OR 1.38, 1.27 to 1.49; n = 5,667,160; 6 studies). This is a comprehensive review adhering to a registered protocol, and guidelines for the Meta-analysis of Observational Studies in Epidemiology were followed, but it is based on predominantly observational data, and in some meta-analyses, between-study heterogeneity is high; therefore, causation cannot be inferred and the results should be interpreted with caution. CONCLUSIONS:When compared with vaginal delivery, cesarean delivery is associated with a reduced rate of urinary incontinence and pelvic organ prolapse, but this should be weighed against the association with increased risks for fertility, future pregnancy, and long-term childhood outcomes. This information could be valuable in counselling women on mode of delivery
Agomelatine, venlafaxine, and running exercise effectively prevent anxiety- and depression-like behaviors and memory impairment in restraint stressed rats
- Author
- A Dagnino-Subiabre
- A Ströhle
- AL Dunn
- AM Thierry
- B Connor
- BL Mason
- BN Greenwood
- BN Greenwood
- C Engesser-Cesar
- CH Bourke
- D Taylor
- E Païzanis
- F Chenu
- FG Graeff
- G Naert
- H Anisman
- H van Praag
- HM Carman
- J Pandaranandaka
- J Pandaranandaka
- Jantarima Charoenphandhu
- Jarinthorn Teerapornpuntakit
- JD Cooke
- JJ Li
- JP Redrobe
- Judith Homberg
- K Higashino
- LA Dawson
- M Antunes
- M Banasr
- M Garner
- M Papp
- M Sairanen
- MJ Millan
- MJ Schaaf
- MS Clark
- N Charoenphandhu
- Narattaphol Charoenphandhu
- Nateetip Krishnamra
- OC Meijer
- PJ Gasser
- PO Hasselgren
- PR Burghardt
- R Morris
- RA de Oliveira
- RD Porsolt
- RE Bowman
- S Dey
- S Lapmanee
- S Lapmanee
- S Persengiev
- Sarawut Lapmanee
- SK Droste
- T Inoue
- TG Heffner
- V Luine
- YF Liu
- YI Nillni
- YM Ulrich-Lai
- ZS Ferreira
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Gene expression patterns in seed plant shoot meristems and leaves: homoplasy or homology?
- Author
- A Brand
- A Goldshmidt
- A Hay
- A Hay
- A Izhaki
- A Sundas-Larsson
- AK Sarkar
- AMF Tomescu
- AS Foster
- B Reinhardt
- B Veit
- BS Young
- C Champagne
- C Lincoln
- CK Boyce
- CK Boyce
- CM Liu
- CW Wardlaw
- CW Wardlaw
- D Hareven
- D Jackson
- D Otsuga
- D Reinhardt
- D Reinhardt
- DJ Beerling
- E Benkova
- E Scarpella
- E Semiarti
- E Souer
- E Vollbrecht
- EM Gifford
- FO Bower
- FO Bower
- G Bharathan
- GS Avery
- GV Reddy
- H Candela
- H Sanders
- H Schoof
- H Shou-Gang
- H Tsukaya
- I Efroni
- I Weir
- ICS Mc Arthur
- IM Sussex
- J Galtier
- J McConnell
- J Nardmann
- JA Doyle
- JA Long
- JA Long
- JF Emery
- JF Golz
- JF Palatnik
- JJ Chen
- John L. Bowman
- JR McConnell
- K Esau
- K Esau
- K Hibara
- K Nikovics
- K Sakakibara
- K Watanabe
- KFX Mayer
- KR Siegfried
- L Dolan
- LC Fletcher
- M Aida
- M Aida
- M Aida
- M Barkoulas
- M Furutani
- M Iwasaki
- M Mundry
- M Schuetz
- ME Byrne
- MG Heisler
- MJ Guo
- MJ Prigge
- MJ Prigge
- MK Barton
- MK Kumaran
- N Matsumoto
- N Ori
- NG Dengler
- O Yanai
- P Kenrick
- PG Gensel
- PM Donnelly
- R Sano
- R Serbet
- R Waites
- RA Kerstetter
- RS Poethig
- RS Poethig
- S Jasinski
- S Sawa
- Sandra K. Floyd
- SD Singer
- SE Scheckler
- SE Scheckler
- SK Floyd
- SK Floyd
- SK Floyd
- T Berleth
- T Blein
- T Koyama
- T Laux
- T Pham
- T Toriba
- TL Phelps-Durr
- U Nath
- W Hagemann
- WN Stewart
- Y Berger
- Y Cheng
- Y Eshed
- Y Eshed
- ZS Wochok
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Materials for hydrogen storage and the Na-Mg-B-H system
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- Antolini E Perez J
- Bé
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- Chen PX Z.
- Christian M Aguey-Zinsou K-F
- Crabtree GW Dresselhaus MS, Buchanan MV
- Czujko T Varin R, Wronski Z, et al.
- Dinsdale AT
- Dobbins T NaraseGowda S, Butler LG
- Dolci F Weidner E, Hoelzel M, et al.
- Driessen A Sanger P, Hemmes H, et al.
- Eberle U Arnold G, von Helmolt R
- Elam CC Padró
- Eremets MI Trojan IA, Medvedev SA, et al.
- Felderhoff M Weidenthaler C, von Helmolt R, et al
- Fichtner M
- Franco F Baricco M, Chierotti MR, et al.
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- Zuttel A Wenger P, Rentsch S, et al.
- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2015
- Field of study
Cardiovascular Activity
- Author
- A Baartscheer
- A Baartscheer
- A Baartscheer
- A Bachmann
- A Bauer
- A Bergdahl
- A Bezold von
- A Biedl
- A Bomzon
- A Bonnacrossi
- A Braillon
- A Brkovic
- A Brueggemann
- A Brüggemann
- A Bucchi
- A Capri
- A Carmeliet
- A Carotenuto
- A Cavalié
- A Cavalli
- A Chatelier
- A Chu
- A Claing
- A Daugherty
- A Daugherty
- A Daugherty
- A Ezzaher
- A Fabiato
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Gagliardi
- A Genao
- A Genovese
- A Gibson
- A Gibson
- A Gibson
- A Goll
- A Grassegger
- A Graziani
- A Grollman
- A Haugan
- A Hedberg
- A Helman
- A Hilditch
- A Hilditch
- A Hilditch
- A Hislop
- A Hislop
- A Hutchaleelaha
- A Inoue
- A Inoue
- A Inoue
- A Jarisch
- A Jarisch
- A Jarisch
- A Karlin
- A Kasai
- A Kochhar
- A Lerman
- A Lopez de Leon
- A Luchner
- A Luchner
- A Lückhoff
- A Lückhoff
- A Malhotra
- A Marchese
- A Marjamäki
- A Marmarou
- A Mattes
- A McRae
- A Menargues
- A Miwa
- A Molteni
- A Molteni
- A Molteni
- A Molteni
- A Monopoli
- A Morita
- A Mülsch
- A Nygren
- A Osajima
- A Reaux
- A Reaux
- A Rudolph
- A Rutledge
- A Salimbeni
- A Sanbe
- A Sattin
- A Schuster
- A Schömig
- A Sculptoreanu
- A Sgoifo
- A Shiroshita-Takeshita
- A Stirrat
- A Sunami
- A Tajima
- A Tamura
- A Terzic
- A Tzanidis
- A Vacca
- A Vacca
- A Vaille
- A Vegh
- A Vegh
- A Verma
- A Volovsek
- A Wahhab
- A Ward
- A Wollenberger
- A Woppmann
- A Wright
- A Yu
- AA Andreadis
- AA Kochegarow
- AA Owji
- AA Pieper
- AB Fawzi
- AB Schreiber
- AB Schreiber
- AB Steffens
- AC Chiou
- AC Dolphin
- AC MacKinnon
- AC MacKinnon
- AC Sulpizio
- ACG Uprichard
- ACG Uprichard
- AD Medhurst
- AD Michel
- AD Michel
- AD Muskett
- AD Muskett
- AE Busch
- AE Busch
- AE Freedlender
- AE RiberoMO
- AEFH Meijer
- AF Green
- AF Green
- AF Green
- AF Green
- AF Green
- AF Odell
- AF Prigent
- AF Prigent
- AG Ciplea
- AGB Kovâch
- AH Cohen
- AH Gradman
- AH Nielsen
- AH Werber
- AH Weston
- AI Faden
- AI Faden
- AI Khan
- AIM Al-Shafei
- AIM Al-Shafei
- AJ Balmforth
- AJ Bold De
- AJ Carter
- AJ Carter
- AJ D’Alonzo
- AJ Gower
- AJ Gower
- AJ Hutchinson
- AJ Kaumann
- AJ Kielblock
- AJ King
- AJ Newell
- AJ Nichols
- AJ Pijl
- AJ Rice
- AJ Susswein
- AJ Szentmiklósi
- AJ Trapani
- AJ Turner
- AK Fouda
- AK Ommaya
- AK Salyers
- AL Blatz
- AL Boura
- AL Golding
- AL Hudson
- AL Hyman
- AL Kwan
- AL Leoni
- AL Perraud
- AL Pichard
- AL Rothaul
- ALA Boura
- AM Al-Obaid
- AM Al-Obaid
- AM Babic
- AM Babic
- AM Beaufort
- AM Broadhurst
- AM Doherty
- AM Duncan
- AM Ehrly
- AM Feldman
- AM Feldman
- AM Gomez
- AM Hackett
- AM Joussen
- AM Lands
- AM Lands
- AM Lands
- AM Lands
- AM Oliveira
- AM Peier
- AM Peier
- AM Romanic
- AM Vineberg
- AM Watson
- AMB Bilate
- AMD Watson
- AN Santos
- AP Albert
- AP Davenport
- AP Ijzerman
- AP Moreno
- AR Dehpour
- AR Hosseini
- AR Liss
- AR Renzetti
- AR Renzetti
- AR Renzetti
- AR Shipolini
- AS Belloni
- AS Bhargava
- AS Harris
- AS Harris
- AS Manning
- AT Beggah
- AT Birmingham
- AT Byrne
- AT Chiu
- AT Chiu
- AT Chiu
- AT Chiu
- AT Chiu
- AT Chiu
- AT Chuang
- AT Chuang
- AT Chui
- ATZ Najbar
- AU ScholzW
- AU ScholzW
- AU ScholzW
- AU Trendelenburg
- AV Gryaznova
- AW Gomoll
- AW Gomoll
- AW Richardson
- AY Jeng
- AY Jeng
- AYW Chang
- B Anner
- B Badio
- B Chevalier
- B Christophe
- B Desta
- B Dieguez
- B Elger
- B Elger
- B Enholm
- B Faddis
- B Folkow
- B Garthoff
- B Garthoff
- B Gotti
- B Gout
- B Gout
- B Gouyon
- B Gumusel
- B Gumusel
- B Halliwell
- B Holmborn
- B Kisch
- B Kumar
- B Kumar
- B Lacombe
- B Lemmer
- B Lemmer
- B Lemmer
- B Lintschinger
- B Malinowska
- B Martin-McNulty
- B Masri
- B Masri
- B Meyrick
- B Meyrick
- B Meyrick
- B Meyrick
- B Müller
- B Nilius
- B Nilius
- B Nilius
- B O’Rourke
- B Peruche
- B Rubin
- B Rubin
- B Sakmann
- B Surawicz
- B Tantini
- B Vannier
- B Vannier
- B Waldeck
- B Wiegershausen
- B Zander
- BA MacLeod
- BA Nassar
- BA Scholkens
- BA Scholkens
- BA Schölkens
- BA Schölkens
- BA Schölkens
- BA Schölkens
- BA Valentine
- BB Clark
- BB Fredholm
- BB Fredholm
- BB Fredholm
- BB Fredholm
- BB Hoffman
- BB Kenny
- BB Wolfe
- BC Knollmannn
- BC Wexler
- BCD GunthorpeMJ
- BCH Tsui
- BD Hoit
- BD Hoit
- BD Hoit
- BD Hoit
- BD Johnson
- BD Nossaman
- BD Nossaman
- BD Perry
- BD Ross
- BE Osborn
- BE Osborne
- BE Sumpio
- BEJ Teunissen
- BF O’Dowd
- BGN WalkerMJA
- BH Ackerman
- BH Choi
- BH Graham
- BJ DeWitt
- BJ DeWitt
- BJ DeWitt
- BJ Hoiycross
- BJ Scherlag
- BJ Walkden
- BK Bhattacharya
- BK Bhattacharya
- BL Partridge
- BM Abbott
- BM Kenyon
- BM Massie
- BM Olivera
- BN Dardik
- BP Bean
- BP Brockway
- BP Brockway
- BP Roques
- BR Duce
- BS Brown
- BS Pallotta
- BV Vargaftig
- BW Zweifach
- BZ Peterson
- BZ Peterson
- C Advenier
- C Backhauß
- C Banfi
- C Basso
- C Baylis
- C Bazzani
- C Cabo
- C Cazaubon
- C Cazaubon
- C Ceconi
- C Ceconi
- C Chabbert
- C Chagneau
- C Chen
- C Clapp
- C Clapp
- C Clark
- C Connolly
- C Coudray
- C Couldwell
- C Couldwell
- C Dacquet
- C Du
- C Dubray
- C Franke
- C Frelin
- C Frelin
- C Frelin
- C Frelin
- C Gabriel
- C Galanos
- C Galanos
- C Gardi
- C Gauthier
- C Gocmen
- C Gonzalez
- C Gros
- C Guiol
- C Harteneck
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- Wienen W Hauel N, van Meel JCA, Narr B, Ries U, Entzeroth M (1993) Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277. Br J Pharmacol 110:245–252 Wong PC, Quan ML, Saye JAM, Bernard R, Crain EJ Jr, Nc- Call DE, Watson CA, Zaspel AM, Smith RD, Wexler RR, Timmermans PBMWM, Chiu AT
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study