1,393 research outputs found

    Resource-Efficient Circuit Compilation for SWAP Networks

    Full text link
    The SWAP network offers a promising solution for addressing the limited connectivity in quantum systems by mapping logical operations to physically adjacent qubits. In this article, we present a novel decomposition strategy for the SWAP network, accompanied by additional extensions that leverage an overcomplete set of native gates. Through comprehensive evaluations, we demonstrate the effectiveness of our protocol in reducing the gate count and streamlining the implementation of generalized SWAP networks and Quantum Random Access Memory (QRAM). Our research tackles the challenges posed by limited connectivity, leading to improved performance of SWAP networks and simplified QRAM implementation, thereby contributing to the advancement of quantum computing technologies.Comment: 23 pages, 15 figure

    The role and possible molecular mechanism of valproic acid in the growth of MCF-7 breast cancer cells

    Get PDF
    Aim To investigate the role of valproic acid (VPA), a class I selective histone deacetylase inhibitor, on Michigan Cancer Foundation (MCF)-7 breast cancer cells, named and explore its possible molecular mechanism. Methods MCF-7 cells were cultured with sodium valproate (0. 5-4.0 mmol/L) for 24 h, 48 h, and 72 h in vitro, respectively. The cell viability, apoptosis, and cell cycle were examined. The activities and protein expressions of caspase-3, caspase-8, and caspase-9 were subsequently assayed. Finally, mRNA and protein expressions of cyclin A, cyclin D1, cyclin E, and p21 were analyzed. Results Sodium valproate suppressed MCF-7 cell growth, induced cell apoptosis, and arrested G1 phase in a timeand concentration- dependent manner, with the relative cell viabilities decreased, cell apoptosis ratios increased, and percentage of G1 phase enhanced (P < 0.05). Increased activity of caspase-3 and caspase-9, but not caspase-8, and increased protein levels were found under sodium valproate (2.0 mmol/L, 48h). P21 was up-regulated and cyclin D1 was down-regulated at both mRNA and protein levels under sodium valproate (2.0 mmol/L, 48h)(P < 0.05), although cyclin E and cyclin A remained changed. Conclusion These results indicate that VPA can suppress the growth of breast cancer MCF-7 cells by inducing apoptosis and arresting G1 phase. Intrinsic apoptotic pathway is dominant for VPA-induced apoptosis. For G1 phase arrest, p21 up-regulation and down-regulation of cyclin D1 may be the main molecular mechanism

    Identification of a novel strain of human papillomavirus from children with diarrhea in China

    Get PDF
    A highly divergent human papillomavirus (HPV) strain, HPV-L55, was identified in fecal samples from children hospitalized with diarrhea in China. The L1 gene of HPV-L55 shares <75% identity with previously reported HPVs, indicating that this virus represents a novel type of HPV. Phylogenetic analysis classified this virus as a member of the gammapapillomaviruses

    Detection of novel viruses in porcine fecal samples from China

    Get PDF
    BACKGROUND: Pigs are well known source of human infectious disease. To better understand the spectrum of viruses present in pigs, we utilized the 454 Life Sciences GS-FLX high-throughput sequencing platform to sequence stool samples from healthy pigs. FINDINGS: Total nucleic acid was extracted from stool samples of healthy piglets and randomly amplified. The amplified materials were pooled and processed using a high-throughput pyrosequencing technique. The raw sequences were deconvoluted on the basis of the barcode and then processed through a standardized bioinformatics pipeline. The unique reads (348, 70 and 13) had limited similarity to known astroviruses, bocaviruses and parechoviruses. Specific primers were synthesized to assess the prevalence of the viruses in healthy piglets. Our results indicate extremely high rates of positivity. CONCLUSIONS: Several novel astroviruses, bocaviruses and Ljungan-like viruses were identified in stool samples from healthy pigs. The rates of isolation for the new viruses were high. The high detection rate, diverse sequences and categories indicate that pigs are well-established reservoirs for and likely sources of different enteric viruses

    Dichlorido[N-(2-pyridylmethyl­idene)benzene-1,4-diamine]zinc(II)

    Get PDF
    In the title compound, [ZnCl2(C12H11N3)], the ZnII atom is four-coordinated by two N atoms from an N-(2-pyridylmethyl­ene)benzene-1,4-diamine ligand and two Cl atoms in a distorted tetra­hedral geometry. In the crystal, the complex mol­ecules are connected by N—H⋯Cl and C—H⋯Cl hydrogen bonds into a two-dimensional layer structure parallel to (110)

    Optical properties of coupled metal-semiconductor and metal-molecule nanocrystal complexes: the role of multipole effects

    Full text link
    We investigate theoretically the effects of interaction between an optical dipole (semiconductor quantum dot or molecule) and metal nanoparticles. The calculated absorption spectra of hybrid structures demonstrate strong effects of interference coming from the exciton-plasmon coupling. In particular, the absorption spectra acquire characteristic asymmetric lineshapes and strong anti-resonances. We present here an exact solution of the problem beyond the dipole approximation and find that the multipole treatment of the interaction is crucial for the understanding of strongly-interacting exciton-plasmon nano-systems. Interestingly, the visibility of the exciton resonance becomes greatly enhanced for small inter-particle distances due to the interference phenomenon, multipole effects, and electromagnetic enhancement. We find that the destructive interference is particularly strong. Using our exact theory, we show that the interference effects can be observed experimentally even in the exciting systems at room temperature.Comment: 9 page

    A Close Look at Spatial Modeling: From Attention to Convolution

    Full text link
    Vision Transformers have shown great promise recently for many vision tasks due to the insightful architecture design and attention mechanism. By revisiting the self-attention responses in Transformers, we empirically observe two interesting issues. First, Vision Transformers present a queryirrelevant behavior at deep layers, where the attention maps exhibit nearly consistent contexts in global scope, regardless of the query patch position (also head-irrelevant). Second, the attention maps are intrinsically sparse, few tokens dominate the attention weights; introducing the knowledge from ConvNets would largely smooth the attention and enhance the performance. Motivated by above observations, we generalize self-attention formulation to abstract a queryirrelevant global context directly and further integrate the global context into convolutions. The resulting model, a Fully Convolutional Vision Transformer (i.e., FCViT), purely consists of convolutional layers and firmly inherits the merits of both attention mechanism and convolutions, including dynamic property, weight sharing, and short- and long-range feature modeling, etc. Experimental results demonstrate the effectiveness of FCViT. With less than 14M parameters, our FCViT-S12 outperforms related work ResT-Lite by 3.7% top1 accuracy on ImageNet-1K. When scaling FCViT to larger models, we still perform better than previous state-of-the-art ConvNeXt with even fewer parameters. FCViT-based models also demonstrate promising transferability to downstream tasks, like object detection, instance segmentation, and semantic segmentation. Codes and models are made available at: https://github.com/ma-xu/FCViT

    Assessment of the key aroma compounds in rose-based products

    Get PDF
    AbstractIn this study, headspace solid phase microextraction–gas chromatography-mass spectrometry and GC-olfactometry were used to analyze the key aroma compounds in three types of rose-based products, including low-temperature extracts (LTEs), high-temperature extracts (HTEs), and rose drinks (RDs). In combination with the Guadagni theory, it was confirmed that the key aroma components of LTE were β-phenyl ethyl alcohol, citronellol, geraniol, and eugenol. The main aroma compounds in HTE were β-phenyl ethyl alcohol, citronellol, geraniol, eugenol, linalool, and rose oxide. The four key aroma compounds in RDs were β-phenyl ethyl alcohol, eugenol, geraniol, and linalool
    corecore