An investigation of interoperability issues between authorisation systems within web services

The existing authorisation systems within the context of Web Services mainly apply two access control approaches – Role-Based Access Control (RBAC) and Attribute-Based Access Control (ABAC). The RBAC approach links an authenticated Web Service Requester to its specific access control permission through roles, but RBAC is not flexible enough to cater for some cases where extra attribute information is needed in addition to the identity. By contrast, the ABAC approach has more flexibility, as it allows a Web Service Requester to submit necessary credentials containing extra attribute information that can fulfil the policies declared by a Web Service Provider, which aims to protect the sensitive resources/services.RBAC and ABAC can only help to establish a unilateral trust relationship between two Web Services to enable a Web Service Provider to make an access control decision. Unfortunately, the nature of Web Services presents a high probability that two Web Services may not know each other. Therefore, successful authorisation may fail, if the Web Service Requester does not trust the Web Service Provider.Trust Negotiation (TN) is also an access control approach, which can provide a bilateral trust relationship between two unknown entities, so it sometimes can enable authorisation success in situations where success is not possible through RBAC or ABAC approaches. However, interoperability issues will arise between authorisation systems within Web Services, where a bilateral trust-based authorisation solution is applied. In addition, a lack of a unified approach that can address the interoperability issues remains as a research problem. This research aims to explore possible factors causing the lack of interoperability first, and then to explore an approach that can address the interoperability issues. The main contributions of this research are an improved interoperability model illustrating interoperability issues at different layers of abstraction, and a novel interoperability-solution design along with an improved TN protocol as an example of utilising this design to provide interoperability between authorisation systems within Web Services

Characterization of Vitamin B12 Supplementation and Correlation with Clinical Outcomes in a Large Longitudinal Study of Early Parkinson's Disease.

ObjectiveIn Parkinson's disease (PD), vitamin B12 levels are lower, and comorbid B12 deficiency has been associated with the development of neuropathy and early gait instability. Because little is known about B12 supplement use in PD, we sought to evaluate its use in a large PD cohort and, as an exploratory analysis, to determine whether baseline characteristics or disease progression differed according to B12 supplementation.MethodsWe utilized data collected as part of the National Institutes of Health Exploratory Trials in PD (NET-PD) Long-term Study (LS-1), a longitudinal study of 1,741 participants. We stratified subjects into 4 groups according to daily supplement use: no B12, multivitamin (MVI) containing < 100 μg B12, B12 ≥ 100 μg, and MVI + B12 ≥ 100 μg. Clinical outcomes were assessed at 3 years for each group using the Unified Parkinson's Disease Rating Scale (UPDRS), its subscores, and selected individual questions.ResultsOf the 1,147 participants who completed the 3-year visit, 41% took an MVI, 2% took B12, 3% took MVI + B12, and 54% reported taking no supplements. At 3 years, no significant differences in clinical outcomes were observed. However, there was a trend toward lower hazard ratios for developing sensory symptoms (UPDRS Item 17) in the MVI (p = 0.08) and B12 + MVI (p = 0.08) groups compared to that in the no supplement group.ConclusionThese results show that supplementation with vitamin B12 ≥ 100 μg is uncommon in early PD. The finding of a trend toward a lower hazard ratio for the development of sensory symptoms in those taking an MVI or B12 + MVI warrants further study

Characterization of vitamin D supplementation and clinical outcomes in a large cohort of early Parkinson's disease.

BackgroundVitamin D (VitD) deficiency is common in Parkinson's disease (PD) and has been raised as a possible PD risk factor. In the past decade, VitD supplementation for potential prevention of age related conditions has become more common. In this study, we sought to characterize VitD supplementation in early PD and determine as an exploratory analysis whether baseline characteristics or disease progression differed according to reported VitD use.MethodsWe analyzed data from the National Institutes of Health Exploratory Trials in Parkinson's Disease (NET-PD) Long-term study (LS-1), a longitudinal study of 1741 participants. Subjects were divided into following supplement groups according to subject exposure (6 months prior to baseline and during the study): no VitD supplement, multivitamin (MVI), VitD ≥400 IU/day, and VitD + multivitamin (VitD+MVI). Clinical status was followed using the Unified Parkinson's Disease Rating Scale, Symbol Digit Modalities Test, total daily levodopa equivalent dose, and Parkinson's Disease Questionnaire.ResultsAbout 5% of subjects took VitD alone, 7% took VitD+MVI, 34% took MVI alone, while 54% took no supplement. Clinical outcomes at 3 years were similar across all groups.ConclusionThis study shows VitD supplementation ≥400 IU/day was not common in early PD and that its use was similar to that seen in the US population. At 3 years, there was no difference in disease progression according to vitamin D supplement use

Connotation and Structure of University Students’ Marriage Values

Marriage values refer to various conditions of individual marriage in the field of selection and consideration, also the individual values reflected in the marriage. The results show that, the connotation of marriage values of college students relates to economy, material foundation, emotion, personality, character, appearance and other factors; college students marriage values has structure model of second order and 5 factors, including intrinsic spiritual needs, external reality requires two second order factors and the economic and material foundation, interest and personality, feelings and beliefs, aesthetic needs, personality and for the five first-order factors. Reliability and validity test and confirmatory factor analysis show that, college students’ marriage values scale has good reliability and validity, and can be used as the college students’ psychological measurement meter

WirePlanner: Fast, Secure and Cost-Efficient Route Configuration for SD-WAN

As enterprises increasingly migrate their applications to the cloud, the demand for secure and cost-effective Wide Area Networking (WAN) solutions for data transmission between branches and data centers grows. Among these solutions, Software-Defined Wide Area Networking (SD-WAN) has emerged as a promising approach. However, existing SD-WAN implementations largely rely on IPSec tunnels for data encryption between edge routers, resulting in drawbacks such as extended setup times and limited throughput. Additionally, the SD-WAN control plane rarely takes both latency and monetary cost into consideration when determining routes between nodes, resulting in unsatisfactory Quality of Service (QoS). We propose WirePlanner, an SD-WAN solution that employs a novel algorithm for path discovery, optimizing both latency and cost, and configures WireGuard tunnels for secure and efficient data transmission. WirePlanner considers two payment methods: Pay-As-You-Go, where users pay for a fixed amount of bandwidth over a certain duration, and Pay-For-Data-Transfer, where users pay for the volume of transmitted data. Given an underlay topology of edge routers and a user-defined budget constraint, WirePlanner identifies a path between nodes that minimizes latency and remains within the budget, while utilizing WireGuard for secure data transmission

Zero-Carbon Communities: Research Hotspots, Evolution, and Prospects

peer reviewedGlobal warming is a worldwide concern, with buildings generating more than 40% of the annual global CO2 emissions. A commonly accepted system of global standards for zero-carbon buildings and communities has not yet been established. In this research, the development history, hotspots, and trends at the urban scale with theoretical and data support are summarized based on the Web of Science (WoS) Core Collection. The review contains works from 1997 to 2022. A total of 19,014 papers were collected, with an overall increasing trend in the number of articles with specific keywords. The scope of the research is broad, covering the environment, sciences, ecology, chemistry, material science, physics, meteorology, atmospheric sciences, and so on. The hotspots in the low-carbon community (LCC) and zero-carbon community (ZCC) involve a wide range of disciplines, and collaborative research between related disciplines should be strengthened to propose practical solutions for the development of zero-carbon cities. The establishment of the ZCC mainly focuses on a zero-carbon-emission construction and zero-carbon operations. This research found approaches such as the choices of building construction and material, a waste recycling system, a regenerating energy system, transportation, and an examination of the community composition to realize the ZCC. In the literature it is presented that the difficulties in the construction of the ZCC are due to the lack of research in practice, operation, and subsequent maintenance. Moreover, other scholars can deepen the research on the hotspots of ZC

Evaluation of a Synthetic Retinoid, Ellorarxine, in the NSC-34 Cell Model of Motor Neuron Disease

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease worldwide and is characterized by progressive muscle atrophy. There are currently two approved treatments, but they only relieve symptoms briefly and do not cure the disease. The main hindrance to research is the complex cause of ALS, with its pathogenesis not yet fully elucidated. Retinoids (vitamin A derivatives) appear to be essential in neuronal cells and have been implicated in ALS pathogenesis. This study explores 4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydroquinoxalin-2-yl)ethylnyl]benzoic acid (Ellorarxine, or DC645 or NVG0645), a leading synthetic retinoic acid, discussing its pharmacological mechanisms, neuroprotective properties, and relevance to ALS. The potential therapeutic effect of Ellorarxine was analyzed in vitro using the WT and SOD1G93A NSC-34 cell model of ALS at an administered concentration of 0.3–30 nM. Histological, functional, and biochemical analyses were performed. Elorarxine significantly increased MAP2 expression and neurite length, increased AMPA receptor GluA2 expression and raised intracellular Ca2+ baseline, increased level of excitability, and reduced Ca2+ spike during depolarization in neurites. Ellorarxine also displayed both antioxidant and anti-inflammatory effects. Overall, these results suggest Ellorarxine shows relevance and promise as a novel therapeutic strategy for treatment of ALS

The influence of employees' perception of over-qualification on career compromise: Mediated by role conflict and sense of relative deprivation

In the external environment with the increasing level of education, there is a general phenomenon of excess qualification in the employment market. This research discusses employee career compromise from the perspective of employee over-qualification based on resource conservation theory and self-regulation theory. Combined with the survey data, a structural equation model (SEM) is constructed, and the mediation effect of relative deprivation and role conflict is analyzed according to the causal mediation model. The research find that employees' perception of over-qualification has three ways to affect employees' career compromise. First, employees' perception of over-qualification has a significant positive impact on their career compromise behavior through employees' emotions and self-cognition. Second, role conflict plays a partial intermediary role between the perception of over-qualification and career compromise by positively affecting career compromise behavior. Third, the sense of relative deprivation plays a partial intermediary role between the perception of over-qualification and career compromise by negatively affecting career compromise behavior. According to the research conclusions, the following suggestions are put forward. Enterprises need to establish a scientific employment mechanism to achieve talent-post matching and fundamentally reduce the phenomenon of over-qualifications. The company should pay attention to employee training, actively guide employees' career planning, instruct employees to correctly understand the sense of over-qualification and play a positive role in guiding employees' career planning

Telehealth Evaluation in the United States: Protocol for a Scoping Review.

BACKGROUND: The rapid expansion of telehealth services, driven by the COVID-19 pandemic, necessitates systematic evaluation to guarantee the quality, effectiveness, and cost-effectiveness of telehealth services and programs in the United States. While numerous evaluation frameworks have emerged, crafted by various stakeholders, their comprehensiveness is limited, and the overall state of telehealth evaluation remains unclear. OBJECTIVE: The overarching goal of this scoping review is to create a comprehensive overview of telehealth evaluation, incorporating perspectives from multiple stakeholder categories. Specifically, we aim to (1) map the existing landscape of telehealth evaluation, (2) identify key concepts for evaluation, (3) synthesize existing evaluation frameworks, and (4) identify measurements and assessments considered in the United States. METHODS: We will conduct this scoping review in accordance with the Joanna Briggs Institute (JBI) methodology for scoping reviews and in line with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). This scoping review will consider documents, including reviews, reports, and white papers, published since January 1, 2019. It will focus on evaluation frameworks and associated measurements of telehealth services and programs in the US health care system, developed by telehealth stakeholders, professional organizations, and authoritative sources, excluding those developed by individual researchers, to collect data that reflect the collective expertise and consensus of experts within the respective professional group. RESULTS: The data extracted from selected documents will be synthesized using tools such as tables and figures. Visual aids like Venn diagrams will be used to illustrate the relationships between the evaluation frameworks from various sources. A narrative summary will be crafted to further describe how the results align with the review objectives, facilitating a comprehensive overview of the findings. This scoping review is expected to conclude by August 2024. CONCLUSIONS: By addressing critical gaps in telehealth evaluation, this scoping review protocol lays the foundation for a comprehensive and multistakeholder assessment of telehealth services and programs. Its findings will inform policy makers, health care providers, researchers, and other stakeholders in advancing the quality, effectiveness, and cost-effectiveness of telehealth in the US health care system. TRIAL REGISTRATION: OSF Registries osf.io/aytus; https://osf.io/aytus. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/55209