Comparison of clinico-pathological characteristics and survival of recurrent ovarian cancer patients on seven different chemo-protocols

Despite the growing prevalence of ovarian cancer (OC) in Pakistan, no literature evidence exists regarding its clinic-pathological characteristics, survival and compliance of patients with recurrent ovarian cancer and various chemo-protocols. An observational study was conducted by enrolling 251 recurrent OC patients on 7 different chemo-protocols, from a specialized cancer care hospital, Lahore, Pakistan, using convenient judgmental sampling. The study was conducted for a period of 6 months. Most of the patients were between 18 and 70 years of age, with IIIC FIGO stage and papillary serous histological grade. As per RECIST, improved partial response (PR) (63.3 %) and complete response (CR) (52.1 %) was observed in the CP (carboplatin + paclitaxel) arm, substantiated by improved median progression free survival (PFS) and overall survival (OS) in CP and CD (carboplatin + docetaxel) arms, respectively, yet with no significant differences in survival curves, PFS (p = 0.12) and OS (p = 0.22). Interestingly, the highest and the lowest patient non-compliance were observed in CG (carboplatin + gemcitabine) (81.6 %) and paclitaxel (4.5 %) arms, resp. As per the hazard model for survival, topotecan showed significant association with the therapy related events/deaths compared to other protocols. These data suggest that CP regimen exhibited improved clinical efficacy and decreased toxicity related non-compliance in recurrent ovarian cancer patients of Lahore

Current perspectives of oncoplastic breast surgery in Pakistan

Oncoplastic breast surgery is based on the concept of tumour-specific immediate reconstruction. It combines both local and distant techniques to maintain breast texture, symmetry and cosmesis without compromising oncological outcome. The current narrative review was planned to highlight the current state and future of oncoplastic breast surgery in low- and middle-income countries where its utilisation in surgical practice remains insubstantial because majority of the surgeons who are treating breast cancer are either general surgeons or breast surgeons who do not have expertise in oncoplastic breast surgery or reconstructive surgery. Moreover, scarcity of financial resources, ignorance about oncoplastic breast surgery techniques, disfigurement distress and cultural taboos coerce women to hide in the shadows with their breast disease. Oncoplastic breast surgery needs more exposure in a developing country like Pakistan. There is a need to establish dedicated oncoplastic breast surgery training centres, fellowship programmes, workshops, and webinars to incorporate such techniques in the practice of breast surgeons

A projected finite element update method for inverse identification of material constitutive parameters in transversely isotropic laminates

In this paper, a novel application of Finite Element Update Method (FEUM) is proposed for the inverse identification of material constitutive parameters in transversely isotropic laminates. Two-dimensional Digital Image Correlation (2D–DIC) is used for full-field measurements which is required for the identification process. Instead of measuring the in-plane displacements, which is a well-known application of 2D–DIC, we seek to measure the pseudo-displacements resulting from out-of-plane (towards camera) deflection of plate under a point load. These pseudo-displacements are basically the perspective projection of the three dimensional displacement fields on the image-plane of the image acquisition system. The cost function in this method is defined in terms of these projections instead of the true displacements – and hence the name Projected Finite Element Update Method (PFEUM). In this article, identification of in-plane elastic moduli of Carbon Fiber Reinforced Plastic (CFRP) plate has been performed using plate bending experiments which show pre-dominantly out-of-plane deflection with little contribution from the in-plane displacements. Identification results are validated by direct experimental measurements of the unknown elastic constants as well as theoretical estimates based on volume ratio of constituents. The results show good conformance between estimated and target values for at least three material parameters namely E1, E2 and G12. Effects of experimental noise on parameter estimates has also been evaluated to explain the observed deviation in estimated parameters with current test configuration

Analysis of deep convolutional neural network models for the fine-grained classification of vehicles

Intelligent transportation systems (ITS) is a broad area that encompasses vehicle identification, classification, monitoring, surveillance, prediction, management, reduction of traffic jams, license plate recognition, etc. Machine learning has practical and significant applications in ITS. Intelligent transportation systems rely heavily on vehicle classification for traffic management and monitoring. This research uses convolutional neural networks to classify cars at fine-grained classifications (make and model). Numerous obstacles must be overcome in order to complete the task, the greatest of which are intra- and inter-class similarities between the manufacturer and model of vehicles, different lighting effects, the shape and size of the vehicle, shadows, camera view angle, background, vehicle speed, colour occlusion and environmental conditions. This paper studies various machine learning algorithms used for the fine-grained classification of vehicles and presents a comparative analysis in terms of accuracy and the size of the implemented deep convolutional neural network (DCNN). Specifically, four DCNN models, mobilenet-v2, inception-v3, vgg-19 and resnet-50, are evaluated with three datasets, BMW-10, Stanford Cars and PAKCars. The evaluation results show that mobileNet-v2 is the smallest model as it is not computationally intensive due to depthwise separable convolution. However, resnet-50 and vgg-19 outperform inception-v3 and mobilenet-v2 in terms of accuracy due to their complex structure

Hepato- and nephro-protective as well as hypoglycemic effects of sea buckthorn berries (Hippophae rhamnoides L.) in rabbits and humans

The hepato- and nephro-protective effects of sea buckthorn berries (Hippophae rhamnoides L) were investigated in paracetamol-induced toxicity in animals and hypoglycemic effects in type II diabetic patients. Crude drug preparation and its methanol extract have shown a profound decrease in paracetamol-induced elevated serum levels of liver and kidney functions under investigation, which suggests a possible therapeutic role of its constituents in hepatic injury and altered kidney functions. Similarly, in human patients with raised glucose levels, sea buckthorn shows hypoglycemic effect which could likely make it a potential therapeutic agent to mange type II diabetes mellitus. However, further investigations are required to unveil the mechanism of action of sea buckthorn preparations in these ailments.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Objectives of Islamic banks: a missive from mission statements and stakeholders’ perceptions

Purpose & Significance: It is believed that the core aim of Islamic institution is idiosyncratic from conventional business entities. Considering this presumption, this study entails to reveal the understandings of various stakeholders about objectives of Islamic banks. Methodology: The research endeavor is based on the findings of two distinctive studies, where study-1 was aimed at investigating the communication of objectives through mission statements of Islamic banks and conventional banks with window operations. Here mission statements were analyzed using content analysis and readability & understandability tests. The study-2, on the other hand, was aimed at investigating the understandings of various stakeholders, both internal (employees) and external (Muslim & non-Muslim customers of both Islamic and conventional banks, employees & management of conventional banks, and business students). 370 responses were received and analyzed in this study. Findings: Findings (study-1) unveil, the fact, that the mission statements of Islamic banks working in Pakistan are not good at communicating the corporate goals clearly. Out of ten banks investigated for study-I, it is evident that only one bank (HBL, with window operations) was at par with readability threshold standards. Thus it was imperative to share that mission statements of Islamic banks are difficult to read and comprehend. Study-2, adds further by revealing that most of the stakeholders are not clear about the objectives of these banks, while customers of conventional banks don’t value the distinctive objectives of Islamic banks. Implications: This study leaves a valuable message for the policy makers and top management of Islamic banks, by focusing on the unattended part on their end, i.e. quality of mission statements and stakeholders’ perception about the objectives of their organization. Thus highlighting the needs of greater emphasis on the communication flow to stakeholders, as the clarity of business purpose may change the way customers react towards the business and opt for banking – customer relation in future. Originality: This study covers a multi-dimensional investigation of the understanding and communication of objectives of Islamic banks. There is dearth of literature focusing on the aspects of content analysis, mission statement readability & understandability and investigation of stakeholders’ perception in tandem

Establishment of health related physical fitness evaluation system for school adolescents aged 12–16 in Pakistan: a cross-sectional study

BackgroundThe decline in adolescent physical fitness is a significant global public health concern, and Pakistan is no exception. The country’s absence of a health-related physical fitness (HRPF) evaluation system has compounded this issue. To bridge this gap, this study aims to develop a scientifically-based HRPF evaluation system for the adolescent population that meets international standards. The evaluation system identifies at-risk children and improves adolescent health outcomes, including obesity, cardiovascular and musculoskeletal disorders, chronic diseases, and psychological illnesses, through crucial physical fitness evaluation. This study specifically aims to establish an HRPF evaluation system for school adolescents aged 12–16 in Pakistan.MethodsA cross-sectional study was conducted among 2,970 school adolescents aged 12–16 years in the South Punjab, Pakistan. The study used a stratified sampling technique to select participants. The HRPF evaluation system included four components: cardiorespiratory endurance, core muscular endurance, muscular strength, and body composition. Data were collected through standardized tests and anthropometric measurements.ResultsThe study’s results indicated that the HRPF evaluation scoring system was feasible and valid for evaluating the HRPF of school adolescents in the South Punjab region of Pakistan. The results of the evaluation system categorized participants into five groups based on their performance: excellent (6.2%), good (24.9%), medium (50.7%), poor (17%), and very poor (1.2%).ConclusionThe study establishes an HRPF evaluation system for Pakistani school adolescents. This system lays the foundation for implementing effective strategies to improve their physical health. The findings offer valuable insights to policymakers, health professionals, and educators, enabling them to promote fitness and devise impactful interventions for enhancing HRPF in this population

COMPERIOSN OF CARDI-VASCULAR ENDURANCE AND SPEED IN URBAN AND RURAL FEMALE STUDENTS OF BAHAUDDIN ZAKARIYA UNIVERSITY PAKISTAN

The study was under taken with the intension of comparing selected physical fitness component in urban and rural female students of BAHAUDDIN ZAKARIYA UNIVERSITY PAKISTAN prominent university in of south Punjab. The selected variables for this study were cardiovascular `endurance and speed. Total subject of 72 female students among them 36 from the urban area of south Punjab district Multan and 36 from the rural area of same district were selected from random sampling technique from the various department of the university. Descriptive Statistics and Independent ‘t’ test were employed using SPSS-19 software. Harvard Step Test and 60 Meter Sprint test were used to collect the required data. Findings show that the urban girls are good in endurance and speed from the rural students result of this findings are unique and shows that the cultural, social and religious differences have a great impact on the physical fitness of females in Pakistan

Impact of duration of therapy on side effect profile of anti-HCV protocol: A retrospective cohort study from two tertiary health facilities in Pakistan

Purpose: To evaluate the plausible risks and adverse effects related to the duration of therapy in hepatitis C (HCV) patients in Lahore, Pakistan.Method: A retrospective observational study involving 250 HCV patients who received combination therapy with ribavirin and interferon was conducted. The patients were segregated into two groups on the basis of duration of therapy (≤ 6 months and > 6 months). Adverse effect profiles of patients under treatment were collected using a pre-validated questionnaire and compared using Pearson’s Chi- Square Test/Chi-Square Goodness-of-Fit tests and unpaired t-test.Results: Patients who underwent treatment for ≤ 6 months frequently encountered side-effects such as GIT disturbance (23.77 %) and joint pains (29.63 %). Additionally, diabetes mellitus (27.86 %) and frequent injections (74.59 %) were the most commonly observed co-morbid condition and disease risk, respectively. On the other hand, in patients who underwent therapy for > 6 months, skin disorders (30.46 %) and gastric acidity (10.15 %) were the most frequently observed side-effects with less frequent reporting on co-morbid conditions and disease risk factors. Moreover, there was a significant reduction in body weight (p = 0.03), serum bilirubin (p = 0.0005), albumin (p = 0.003) and triglycerides (p = 0.006) levels due to longer duration of treatment.Conclusion: The data suggest that treatment-related risks are higher among HCV patients on shorter treatment duration whereas adverse events subside in patients on longer duration of therapy (>6 months). Changes in biochemical profile were also more evident in those receiving treatment for periods >6 months.Keywords: Interferon, Ribavirin, Side effects, Duration of therapy, Outcomes of therap