The Rhesus Factor and Disease Prevention

First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2004. ©The Trustee of the Wellcome Trust, London, 2004. All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on 3 June 2003. Introduction by Professor Doris T Zallen.Annotated and edited transcript of a Witness Seminar held on 3 June 2003. Introduction by Professor Doris T Zallen.Annotated and edited transcript of a Witness Seminar held on 3 June 2003. Introduction by Professor Doris T Zallen.Annotated and edited transcript of a Witness Seminar held on 3 June 2003. Introduction by Professor Doris T Zallen.Annotated and edited transcript of a Witness Seminar held on 3 June 2003. Introduction by Professor Doris T Zallen.Annotated and edited transcript of a Witness Seminar held on 3 June 2003. Introduction by Professor Doris T Zallen.Consists of the edited transcripts of Witness SeThe prevention of rhesus disease of the newborn is a stunning medical success story. This disease afflicted thousands of newborns each year, causing serious health problems, even death. Yet from the early 1940s to the 1970s – British and American researchers uncovered the basis of the disease and developed the medical intervention that could prevent its occurrence. Many of the key steps leading to this remarkable achievement took place at the University of Liverpool School of Medicine. Chaired by Professor Sir David Weatherall, this Witness Seminar examines the factors that triggered these studies and the challenges that confronted scientists and clinicians; the intellectual, institutional, and social factors that guided the work; the crucial insights; and the vistas that the prevention of rhesus disease has opened in fetal medicine. Participants include Professor Robin Coombs, the late Professor Ronald Finn, Dr Nevin Hughes-Jones, Professor Patrick Mollison, Dr Archie Norman, Dr Derrick Tovey, Professor Charles Whitfield, Professor John Woodrow and Professor Doris Zallen. Zallen, D T, Christie D A, Tansey E M. (eds) (2004) The Rhesus factor and disease prevention, Wellcome Witnesses to Twentieth Century Medicine, vol. 22. London: The Wellcome Trust Centre for the History of Medicine at UCL. ISBN 978 0 85484 099 1minars organized by the History of Twentieth Century Medicine Group and held at the Wellcome Institute for the History of Medicine.The Wellcome Trust Centre for the History of Medicine at University College London is funded by the Wellcome Trust,which is a registered charity, no. 210183

Equilibrium and non-equilibrium fluctuations in a glass-forming liquid

Glass-forming liquids display strong fluctuations -- dynamical heterogeneities -- near their glass transition. By numerically simulating a binary Weeks-Chandler-Andersen liquid and varying both temperature and timescale, we investigate the probability distributions of two kinds of local fluctuations in the non-equilibrium (aging) regime and in the equilibrium regime; and find them to be very similar in the two regimes and across temperatures. We also observe that, when appropriately rescaled, the integrated dynamic susceptibility is very weakly dependent on temperature and very similar in both regimes.Comment: v1: 5 pages, 4 figures v2: 5 pages, 4 figures. Now includes results at three temperatures, two of them above T_{MCT} and one below T_{MCT}; and more extensive discussion of connections to experiment

Integrating New Values with Old Uses in the Relicensing of Kingsley Dam and Related Facilities (Making Part of the Problem a Part of the Solution)

21 pages (includes illustrations and map)

Integrating New Values with Old Uses in the Relicensing of Kingsley Dam and Related Facilities (Making Part of the Problem a Part of the Solution)

21 pages (includes illustrations and map)

Scaled frequency-dependent transport in the mesoscopically phase-separated colossal magnetoresistive manganite La_{0.625-y}Pr_yCa_{0.375}MnO_3

We address the issue of massive phase separation (PS) in manganite family of doped Mott insulators through ac conductivity measurements on La$_{0.625-y}$Pr$_{y}$Ca$_{0.375}$MnO$_{3}$ (0.375 $\leq$ y $\leq$ 0.275), and establish applicability of the scaling theory of percolation in the critical regime of the PS. Measurements of dc resistivity, magnetization (M(T)) and electron diffraction show incomplete growth of a ferromagnetic (FM) metallic component on cooling the high temperature charge ordered (CO) phase well below Curie temperature. The impedance $\mid$Z(T,f)$\mid$ measured over a frequency (f) range of 10 Hz to 10 MHz in the critical regime follows a universal scaling of the form $\approx$ R(T,0)g(f$\xi^{2+\theta}$) with $\theta$ $\approx$ 0.86 and the normalized correlation length varying from 1 to 4, suggesting anomalous diffusion of holes in percolating FM clusters.Comment: 12 pages and 5 figure

Spectral responses in granular compaction

The slow compaction of a gently tapped granular packing is reminiscent of the low-temperature dynamics of structural and spin glasses. Here, I probe the dynamical spectrum of granular compaction by measuring a complex (frequency-dependent) volumetric susceptibility $\tilde{\chi}_v$. While the packing density $\rho$ displays glass-like slow relaxations (aging) and history-dependence (memory) at low tapping amplitudes, the susceptibility $\tilde{\chi}_v$ displays very weak aging effects, and its spectrum shows no sign of a rapidly growing timescale. These features place $\tilde{\chi}_v$ in sharp contrast to its dielectric and magnetic counterparts in structural and spin glasses; instead, $\tilde\chi_v$ bears close similarities to the complex specific heat of spin glasses. This, I suggest, indicates the glass-like dynamics in granular compaction are governed by statistically rare relaxation processes that become increasingly separated in timescale from the typical relaxations of the system. Finally, I examine the effect of finite system size on the spectrum of compaction dynamics. Starting from the ansatz that low frequency processes correspond to large scale particle rearrangements, I suggest the observed finite size effects are consistent with the suppression of large-scale collective rearrangements in small systems.Comment: 18 pages, 17 figures. Submitted to PR

Patterned Gene Expression Directs Bipolar Planar Polarity in Drosophila

AbstractDuring convergent extension in Drosophila, polarized cell movements cause the germband to narrow along the dorsal-ventral (D-V) axis and more than double in length along the anterior-posterior (A-P) axis. This tissue remodeling requires the correct patterning of gene expression along the A-P axis, perpendicular to the direction of cell movement. Here, we demonstrate that A-P patterning information results in the polarized localization of cortical proteins in intercalating cells. In particular, cell fate differences conferred by striped expression of the even-skipped and runt pair-rule genes are both necessary and sufficient to orient planar polarity. This polarity consists of an enrichment of nonmuscle myosin II at A-P cell borders and Bazooka/PAR-3 protein at the reciprocal D-V cell borders. Moreover, bazooka mutants are defective for germband extension. These results indicate that spatial patterns of gene expression coordinate planar polarity across a multicellular population through the localized distribution of proteins required for cell movement

Exact Constructions of a Family of Dense Periodic Packings of Tetrahedra

The determination of the densest packings of regular tetrahedra (one of the five Platonic solids) is attracting great attention as evidenced by the rapid pace at which packing records are being broken and the fascinating packing structures that have emerged. Here we provide the most general analytical formulation to date to construct dense periodic packings of tetrahedra with four particles per fundamental cell. This analysis results in six-parameter family of dense tetrahedron packings that includes as special cases recently discovered "dimer" packings of tetrahedra, including the densest known packings with density $\phi= 4000/4671 = 0.856347...$. This study strongly suggests that the latter set of packings are the densest among all packings with a four-particle basis. Whether they are the densest packings of tetrahedra among all packings is an open question, but we offer remarks about this issue. Moreover, we describe a procedure that provides estimates of upper bounds on the maximal density of tetrahedron packings, which could aid in assessing the packing efficiency of candidate dense packings.Comment: It contains 25 pages, 5 figures

Elasticity of highly cross-linked random networks

Starting from a microscopic model of randomly cross-linked particles with quenched disorder, we calculate the Laudau-Wilson free energy S for arbitrary cross-link densities. Considering pure shear deformations, S takes the form of the elastic energy of an isotropic amorphous solid state, from which the shear modulus can be identified. It is found to be an universal quantity, not depending on any microscopic length-scales of the model.Comment: 6 pages, 5 figure