Classical integrability of the O(N) nonlinear Sigma model on a half-line

The classical integrability the O(N) nonlinear sigma model on a half-line is examined, and the existence of an infinity of conserved charges in involution is established for the free boundary condition. For the case N=3 other possible boundary conditions are considered briefly.Comment: 12 Pages. Latex file (process twice

On the sine-Gordon--Thirring equivalence in the presence of a boundary

In this paper, the relationship between the sine-Gordon model with an integrable boundary condition and the Thirring model with boundary is discussed and the reflection $R$-matrix for the massive Thirring model, which is related to the physical boundary parameters of the sine-Gordon model, is given. The relationship between the the boundary parameters and the two formal parameters appearing in the work of Ghoshal and Zamolodchikov is discussed.Comment: 14 pages, Latex, to be published in Int. J. Mod. Phys. A. Two references adde

The impact of hypoxia on oncolytic virotherapy

The hypoxic tumor microenvironment plays significant roles in tumor cell metabolism and survival, tumor growth, and progression. Hypoxia modulates target genes in target cells mainly through an oxygen-sensing signaling pathway mediated by hypoxia-inducible factor of transcription factors. As a result, hypoxic tumor cells are resistant to conventional therapeutics such as radiation and chemotherapy. Oncolytic virotherapy may be a promising novel therapeutic for hypoxic cancer. Some oncolytic viruses are better adapted than others to the hypoxic tumor environment. Replication of adenoviruses from both groups B and C is inhibited, yet replication of herpes simplex virus is enhanced. Hypoxia seems to exert little or no effect on the replication of other oncolytic viruses. Vaccinia virus displayed increased cytotoxicity in some hypoxic cancer cells even though viral protein synthesis and transgene expression were not affected. Vesicular stomatitis virus replicated to similar levels in both hypoxic and normoxic conditions, and is effective for killing hypoxic cancer cells. However, vesicular stomatitis virus and reovirus, but not encephalomyocarditis virus, are sensitive to elevated levels of hypoxia-inducible factor-1α in renal cancer cells with the loss of von Hippel-Lindau tumor suppressor protein, because elevated hypoxia-inducible factor activity confers dramatically enhanced resistance to cytotoxicity mediated by vesicular stomatitis virus or reovirus. A variety of hypoxia-selective and tumor-type-specific oncolytic adenoviruses, generated by incorporating hypoxia-responsive elements into synthetic promoters to control essential genes for viral replication or therapeutic genes, have been shown to be safe and efficacious. Hypoxic tumor-homing macrophages can function effectively as carrier cells to deliver an oncolytic adenovirus to the hypoxic/necrotic areas of the tumor. It is envisioned that further improved oncolytic viruses will be highly effective against hypoxic tumor, especially when combined with other therapeutic regimens such as immunotherapy, radiation therapy, and/or chemotherapy. © 2011 Guo