BLEEDING FROM THE VARICOSE-EXPANDED VEINS OF A GULLET AT A CIRRHOSIS OF A LIVER

Studied clinical – epidemiological features of current and the analysis of lethal cases at patients with cirrhoses of a liver various aetiologies owing to bleedings from varicose -the expanded veins of a gullet (VEVG) are studied. It is lead skrining the analysis of 310 cards of stationary supervision of patients with a cirrhoses of a liver various aetiologies and the retrospective analysis of 37 case records of patients died owing to a bleeding from VEVG, was on hospitalization in 2015 and 2016 in MBUZ KGK BSMP «Hospital of the first help». The group of risk is revealed at VEVG on a floor, age; the greatest degree VEVG at a bleeding, aetiologies a cirrhosis of a liver at a bleeding and indications for the emergency surgical help

Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.

Despite showing clinical activity in BRAF-mutant melanoma, the MEK inhibitor (MEKi) trametinib has failed to show clinical benefit in KRAS-mutant colorectal cancer. To identify mechanisms of resistance to MEKi, we employed a pharmacogenomic analysis of MEKi-sensitive versus MEKi-resistant colorectal cancer cell lines. Strikingly, interferon- and inflammatory-related gene sets were enriched in cell lines exhibiting intrinsic and acquired resistance to MEK inhibition. The bromodomain inhibitor JQ1 suppressed interferon-stimulated gene (ISG) expression and in combination with MEK inhibitors displayed synergistic effects and induced apoptosis in MEKi-resistant colorectal cancer cell lines. ISG expression was confirmed in patient-derived organoid models, which displayed resistance to trametinib and were resensitized by JQ1 co-treatment. In in vivo models of colorectal cancer, combination treatment significantly suppressed tumor growth. Our findings provide a novel explanation for the limited response to MEK inhibitors in KRAS-mutant colorectal cancer, known for its inflammatory nature. Moreover, the high expression of ISGs was associated with significantly reduced survival of colorectal cancer patients. Excitingly, we have identified novel therapeutic opportunities to overcome intrinsic and acquired resistance to MEK inhibition in colorectal cancer

Salmonellosis under a mask of surgical diseases

Features of clinical displays at sick by a salmonellosis with suspicion on surgical diseases and tactics of introduction of such patients are studied. At 13 patients with the confirmed salmonellosis (with gastrointestinal the form-10, generalized the form-3) preliminary hospitalized the analysis of the case record is lead to a surgical hospital with suspicion on various surgical diseases. Carried out researches have established complexity of differential diagnostics at a primary stage in communication with similarity of clinical displays of illnesses. And only dynamic supervision over patients, and in some cases necessity of surgical intervention allowed to specify the diagnosis