Robust filtering for gene expression time series data with variance constraints

This is the post print version of the article. The official published version can be obtained from the link below - Copyright 2007 Taylor & Francis Ltd.In this paper, an uncertain discrete-time stochastic system is employed to represent a model for gene regulatory networks from time series data. A robust variance-constrained filtering problem is investigated for a gene expression model with stochastic disturbances and norm-bounded parameter uncertainties, where the stochastic perturbation is in the form of a scalar Gaussian white noise with constant variance and the parameter uncertainties enter both the system matrix and the output matrix. The purpose of the addressed robust filtering problem is to design a linear filter such that, for the admissible bounded uncertainties, the filtering error system is Schur stable and the individual error variance is less than a prespecified upper bound. By using the linear matrix inequality (LMI) technique, sufficient conditions are first derived for ensuring the desired filtering performance for the gene expression model. Then the filter gain is characterized in terms of the solution to a set of LMIs, which can easily be solved by using available software packages. A simulation example is exploited for a gene expression model in order to demonstrate the effectiveness of the proposed design procedures.This work was supported in part by the Engineering and Physical Sciences Research Council (EPSRC) of the UK under Grants GR/S27658/01 and EP/C524586/1, the Biotechnology and Biological Sciences Research Council (BBSRC) of the UK under Grants BB/C506264/1 and 100/EGM17735, the Nuffield Foundation of the UK under Grant NAL/00630/G, and the Alexander von Humboldt Foundation of Germany

On nonlinear H∞ filtering for discrete-time stochastic systems with missing measurements

Copyright [2008] IEEE. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Brunel University's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to [email protected]. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.In this paper, the H∞ filtering problem is investigated for a general class of nonlinear discrete-time stochastic systems with missing measurements. The system under study is not only corrupted by state-dependent white noises but also disturbed by exogenous inputs. The measurement output contains randomly missing data that is modeled by a Bernoulli distributed white sequence with a known conditional probability. A filter of very general form is first designed such that the filtering process is stochastically stable and the filtering error satisfies H infin performance constraint for all admissible missing observations and nonzero exogenous disturbances under the zero-initial condition. The existence conditions of the desired filter are described in terms of a second-order nonlinear inequality. Such an inequality can be decoupled into some auxiliary ones that can be solved independently by taking special form of the Lyapunov functionals. As a consequence, a linear time-invariant filter design problem is discussed for the benefit of practical applications, and some simplified conditions are obtained. Finally, two numerical simulation examples are given to illustrate the main results of this paper

Filtering for networked stochastic time-delay systems with sector nonlinearity

Copyright [2009] IEEE. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Brunel University's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to [email protected]. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.This paper is concerned with the filtering problem for a class of discrete-time stochastic nonlinear networked control systems with network-induced incomplete measurements. The incomplete measurements include both the multiple random communication delays and random packet losses, which are modeled by a unified stochastic expression in terms of a set of indicator functions that is dependent on certain stochastic variable. The nonlinear functions are assumed to satisfy the sector nonlinearities. The purpose of the addressed filtering problem is to design a linear filter such that the filtering-error dynamics is exponentially mean-square stable. By using the linear-matrix-inequality (LMI) method and delay-dependent technique, sufficient conditions are derived which are dependent on the occurrence probability of both the random communication delays and missing measurement. The filter gain is then characterized by the solution to a set of LMIs. A simulation example is exploited to demonstrate the effectiveness of the proposed design procedures

Structural and magnetic properties of MnCo1-xFexSi alloys

The crystal structures, martensitic structural transitions and magnetic properties of MnCo1-xFexSi (0 <= x <= 0.50) alloys were studied by differential scanning calorimetry (DSC), x-ray powder diffraction (XRD) and magnetic measurements. In high-temperature paramagnetic state, the alloys undergo a martensitic structural transitions from the Ni2In-type hexagonal parent phase to the TiNiSi-type orthorhombic martensite. Both the martensitic transition temperature (TM) and Curie temperatures of martensite (T_C^M) decrease with increasing Fe content. The introduced Fe atoms establish ferromagnetic (FM) coupling between Fe-Mn atoms and destroy the double spiral antiferromagnetic (AFM) coupling in MnCoSi compound, resulting in a magnetic change in the martensite phase from a spiral AFM state to a FM state. For the alloys with x = 0.10, 0.15 and 0.20, a metamagnetic transition was observed in between the two magnetic states. A magnetostructural phase diagram of MnCo1-xFexSi (0 <= x <= 0.50) alloys was proposed.Comment: 18 pages, 6 figs, submitted to JMM

Variance-constrained multiobjective control and filtering for nonlinear stochastic systems: A survey

The multiobjective control and filtering problems for nonlinear stochastic systems with variance constraints are surveyed. First, the concepts of nonlinear stochastic systems are recalled along with the introduction of some recent advances. Then, the covariance control theory, which serves as a practical method for multi-objective control design as well as a foundation for linear system theory, is reviewed comprehensively. The multiple design requirements frequently applied in engineering practice for the use of evaluating system performances are introduced, including robustness, reliability, and dissipativity. Several design techniques suitable for the multi-objective variance-constrained control and filtering problems for nonlinear stochastic systems are discussed. In particular, as a special case for the multi-objective design problems, the mixed H 2 / H ∞ control and filtering problems are reviewed in great detail. Subsequently, some latest results on the variance-constrained multi-objective control and filtering problems for the nonlinear stochastic systems are summarized. Finally, conclusions are drawn, and several possible future research directions are pointed out