The genetics of circadian rhythms, sleep and health

Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular clocks, which serve to coordinate internal time with the external world. The circadian system is a master regulator of nearly all physiology and its disruption has major consequences on health. Sleep and circadian rhythm disruption (SCRD) is a ubiquitous feature in today’s 24/7 society, and studies on shift-workers have shown that SCRD can lead not only to cognitive impairment, but also metabolic syndrome and psychiatric illness including depression (1,2). Mouse models of clock mutants recapitulate these deficits, implicating mechanistic and causal links between SCRD and disease pathophysiology (3–5). Importantly, treating clock disruption reverses and attenuates these adverse health states in animal models (6,7), thus establishing the circadian system as a novel therapeutic target. Significantly, circadian and clock-controlled gene mutations have recently been identified by Genome-Wide Association Studies (GWAS) in the aetiology of sleep, mental health and metabolic disorders. This review will focus upon the genetics of circadian rhythms in sleep and health

The genetics of circadian rhythms, sleep and health

Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular clocks, which serve to coordinate internal time with the external world. The circadian system is a master regulator of nearly all physiology and its disruption has major consequences on health. Sleep and circadian rhythm disruption (SCRD) is a ubiquitous feature in today’s 24/7 society, and studies on shift-workers have shown that SCRD can lead not only to cognitive impairment, but also metabolic syndrome and psychiatric illness including depression (1,2). Mouse models of clock mutants recapitulate these deficits, implicating mechanistic and causal links between SCRD and disease pathophysiology (3–5). Importantly, treating clock disruption reverses and attenuates these adverse health states in animal models (6,7), thus establishing the circadian system as a novel therapeutic target. Significantly, circadian and clock-controlled gene mutations have recently been identified by Genome-Wide Association Studies (GWAS) in the aetiology of sleep, mental health and metabolic disorders. This review will focus upon the genetics of circadian rhythms in sleep and health

A Technique to Reduce the Processing Time of Defect Detection in Glass Tubes

The evolution of the glass production process requires high accuracy in defects detection and faster production lines. Both requirements result in a reduction in the processing time of defect detection in case of real-time inspection. In this paper, we present an algorithm for defect detection in glass tubes that allows such reduction. The main idea is based on the reduce the image areas to investigate by exploiting the features of images. In our experiment, we utilized two algorithms that have been successfully applied in the inspection of pharmaceutical glass tube: Canny algorithm and MAGDDA. The proposed solution, applied on both algorithms, doesn’t compromise the quality of detection and allows us to achieve a performance gain of 66% in terms of processing time, and 3 times in term of throughput (frames per second), in comparison with standard implementations. An automatic procedure has been developed to estimate optimal parameters for the algorithm by considering the specific production process