Slow Adaptive OFDMA Systems Through Chance Constrained Programming

Adaptive OFDMA has recently been recognized as a promising technique for providing high spectral efficiency in future broadband wireless systems. The research over the last decade on adaptive OFDMA systems has focused on adapting the allocation of radio resources, such as subcarriers and power, to the instantaneous channel conditions of all users. However, such "fast" adaptation requires high computational complexity and excessive signaling overhead. This hinders the deployment of adaptive OFDMA systems worldwide. This paper proposes a slow adaptive OFDMA scheme, in which the subcarrier allocation is updated on a much slower timescale than that of the fluctuation of instantaneous channel conditions. Meanwhile, the data rate requirements of individual users are accommodated on the fast timescale with high probability, thereby meeting the requirements except occasional outage. Such an objective has a natural chance constrained programming formulation, which is known to be intractable. To circumvent this difficulty, we formulate safe tractable constraints for the problem based on recent advances in chance constrained programming. We then develop a polynomial-time algorithm for computing an optimal solution to the reformulated problem. Our results show that the proposed slow adaptation scheme drastically reduces both computational cost and control signaling overhead when compared with the conventional fast adaptive OFDMA. Our work can be viewed as an initial attempt to apply the chance constrained programming methodology to wireless system designs. Given that most wireless systems can tolerate an occasional dip in the quality of service, we hope that the proposed methodology will find further applications in wireless communications

On the accuracy of solving confluent Prony systems

In this paper we consider several nonlinear systems of algebraic equations which can be called "Prony-type". These systems arise in various reconstruction problems in several branches of theoretical and applied mathematics, such as frequency estimation and nonlinear Fourier inversion. Consequently, the question of stability of solution with respect to errors in the right-hand side becomes critical for the success of any particular application. We investigate the question of "maximal possible accuracy" of solving Prony-type systems, putting stress on the "local" behavior which approximates situations with low absolute measurement error. The accuracy estimates are formulated in very simple geometric terms, shedding some light on the structure of the problem. Numerical tests suggest that "global" solution techniques such as Prony's algorithm and ESPRIT method are suboptimal when compared to this theoretical "best local" behavior

Transgenic cassava lines carrying heterologous alternative oxidase (AtAOX1a) showed impaired quantitative and qualitative response to embryogenesis

In our approach to control reactive oxygen species produced as a result of oxidative stress experienced by cassava roots during harvesting, a phenomena which causes postharvest physiological deterioration in the roots, we transformed cassava variety TMS 60444 with the AtAOX1a gene, driven by the 35S promoter, using agrobacterium-mediated approach. Extracted genomic DNAs of putative transgenic lines were screened using polymerase chain reaction technique (PCR). Messenger RNA was extracted from selected PCR-positive lines for reverse transcription-PCR analysis for gene expression. To screen positive lines for gene function, leaf lobes from two transgenic lines with a line carrying an empty vector and the wild type were subjected to somatic embryogenesis (SE), a known oxidative stress process. The results show that the wild type, at 16 days after initiation (DAI) of the leaf lobes on callus initiation medium, had the highest (100%) number of leaf lobes that produced at least one observed organised embryogenic structure (OES). This was followed by PEV-3, the empty vector plant with 50% OES production, while PB-3 had the least percent (20%) of leaf lobes with OES. PB-3 line also had no OES at all in five out of the seven periods of data collection. During the period, the wild type recorded the highest attainable OES quality score of 2.0 (on a scale of 1-5 where 1=bad and 5=excellent) at the first initiation cycle. Both the transgenic lines and the empty-vector plantlet recorded quality score of 1.0. It seems AtAOX1a only hinders OES development, but exerts little effect on the quality, if OES does not degenerate after development.Keywords: Genomic DNAs, reverse transcription-PCR, somatic embryogenesis (SE)African Journal of Biotechnology Vol. 12(27), pp. 4303-430

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 2: androgen-receptor cofactors and bypass pathways

Prostate cancer is the second leading cause of cancer related deaths in men from the western world. Treatment of prostate cancer has relied on androgen deprivation therapy for the past 50 years. Response rates are initially high (70-80%), however almost all patients develop androgen escape and subsequently die within 1-2 years. Unlike breast cancer, alternative approaches (chemotherapy and radiotherapy) do not increase survival time. The high rate of prostate cancer mortality is therefore strongly linked to both development of androgen escape and the lack of alternate therapies. AR mutations and amplifications can not explain all cases of androgen escape and post-translational modification of the AR has become an alternative theory. However recently it has been suggested that AR co-activators e.g. SRC-1 or pathways the bypass the AR (Ras/MAP kinase or PI3K/Akt) may stimulated prostate cancer progression independent of the AR. This review will focus on how AR coactivators may act to increase AR transactivation during sub-optimal DHT concentrations and also how signal transduction pathways may promote androgen escape via activation of transcription factors, e.g. AP-1, c-Myc and Myb, that induce cell proliferation or inhibit apoptosis

Energy-Efficient Resource Allocation for IRS-aided MISO System with SWIPT

Combining simultaneous wireless information and power transfer (SWIPT) and intelligent reflecting surface (IRS) is a feasible scheme to enhance the energy efficiency (EE) performance. In this paper, we investigate a multiuser IRS-aided multiple-input single-output (MISO) system with SWIPT. For the purpose of maximizing the EE of the system, we jointly optimize the base station (BS) transmit beamforming vectors, the IRS reflective beamforming vector and the power splitting (PS) ratios, while considering the maximum transmit power budget, the IRS reflection constraints and the quality of service (QoS) requirements containing the minimum data rate and the minimum harvested energy per user. As the proposed EE maximization problem is non-convex and extremely complex, we propose an efficient alternating optimization (AO) algorithm by decoupling the original problem into three subproblems which are tackled iteratively by using the Dinkelbach method. In particular, we apply the successive convex approximation (SCA) as well as the semi-definite relaxation (SDR) techniques to solve the non-convex transmit beamforming and reflective beamforming optimization subproblems. Numerical results confirm the effectiveness of the AO algorithm as well as the benefit of deploying IRS for enhancing the EE performance compared with the benchmark schemes

Troubleshooting Arterial-Phase MR Images of Gadoxetate Disodium-Enhanced Liver.

Gadoxetate disodium is a widely used magnetic resonance (MR) contrast agent for liver MR imaging, and it provides both dynamic and hepatobiliary phase images. However, acquiring optimal arterial phase images at liver MR using gadoxetate disodium is more challenging than using conventional extracellular MR contrast agent because of the small volume administered, the gadolinium content of the agent, and the common occurrence of transient severe motion. In this article, we identify the challenges in obtaining high-quality arterial-phase images of gadoxetate disodium-enhanced liver MR imaging and present strategies for optimizing arterial-phase imaging based on the thorough review of recent research in this field

Dose-dependent and combined effects of N-methyl-D-aspartate receptor antagonist MK-801 and nitric oxide synthase inhibitor nitro-L-arginine on the survival of retinal ganglion cells in adult hamsters

This study investigated the effects of daily intraperitoneal injections of N-methyl-D-aspartate receptor antagonist MK-801 and nitric oxide synthase inhibitor nitro-L-arginine (L-NA) on the survival of retinal ganglion cells (RGCs) at 1 and 2 weeks after unilateral optic nerve transection in adult hamsters. The left optic nerves of all animals were transected intraorbitally 1 mm from the optic disc and RGCs were retrogradely labeled with Fluorogold before they received different daily dosages of single MK-801 or L-NA as well as daily combinational treatments of these two chemicals. All experimental and control animals survived for 1 or 2 weeks after optic nerve transection. Our results revealed that the mean numbers of surviving RGCs increased and then decreased when the dosage of MK-801 (1.0, 3.0 and 4.5 mg/kg) and L-NA (1.5, 3.0, 4.5 and 6.0 mg/kg) increased at both 1 and 2 weeks survival time points. Daily combinational use of 1.0 mg/kg MK-801 and 1.5 mg/kg L-NA lead to a highest RGC number that was even higher than the sum of the RGC numbers in 1.0 mg/kg MK-801 and 1.5 mg/kg L-NA subgroups at 2 weeks. These findings indicated that both MK-801 and L-NA can protect axotomized RGCs in a dose-dependent manner and combinational treatment of these chemicals possesses a potentiative and protective effect.published_or_final_versio

GAP-43 expression correlates with spinal motoneuron regeneration following root avulsion

Background: The growth-associated protein GAP-43 plays a crucial role in axonal regeneration in injured neurons. Methods: We have used immunohistochemistry to investigate the expression of GAP-43 in spinal motoneurons during nerve reconstruction following root avulsion in the neonatal and adult rats. Results: Following the injury, GAP-43-immunoreactivity (IR) could be found in adult avulsed motoneurons as early as 1 day, increased from 3 to 7 days and reached a maximal level at 2 weeks post-injury. The up-regulation of GAP-43 in adult avulsed motoneurons was accompanied with the axonal regeneration indicated by numerous regenerating motor axons entering the reimplanted ventral root and nerve. In contrast, GAP-43-IR could not be found in the neonatal avulsed motoneurons at any examined post-injury time points. This failure of up-regulation of GAP-43 was coincident with no axonal regeneration in the reimplanted nerve in the neonatal rats. Conclusion: Close association of GAP-43 expression and capacity of regeneration in reimplanted spinal nerve of avulsed motoneurons suggests that GAP-43 is a potential therapeutic target for treatment of root avulsion of brachial plexus. © 2009 Yuan et al; licensee BioMed Central Ltd.published_or_final_versio