Expression of apoptosis receptors on the cells in patients with herpes infections

Expressions of CD95 receptors on the leukocytes in patients with HSV-1,2 infection as well as on the cervical cells was decreased (р < 0,05). No significant changes of expression of CD95 receptor in patients with cytomegalovirus were revealed

Phytopreparation - inhibitor of bacterial catalase in therapy of patients with flegmons

The phytopreparation on the papaya base may be regarded as indirect antibiotic, which inhibits the staphylococcus catalase. The estimation of clinical effectiveness of therapy by BioReks demonstrates that such therapy leads to the faster arresting of main inflammatory symptoms and complete healing of wound

The herbalmedicine with nondirect antibacterial action in the complex therapy of patients with odonthogenic flegmons

The investigation of the clinical effectiveness of the complex treatment with BioReks was done. This therapy leads to more fast elimination of the main inflammations markers and to more effective reparation. The good effect of the BioReks connects with decreasing of defence of inflectional agents to bactericidal actions of neutrophils and antioxidant properties if medicine

Anti-Bacterial and Anti-Inflammatory Effects of Toothpaste with Swiss Medicinal Herbs towards Patients Suffering from Gingivitis and Initial Stage of Periodontitis: From Clinical Efficacy to Mechanisms

Objective: To distinguish clinical effects and mechanisms of sodium monofluorophosphate plus xylitol and herbal extracts of Swiss medicinal plants (Chamomilla recutita, Arnica montana, Echinacea purpurea, and Salvia officinalis). Materials and Methods: A 2-month-long comparative clinical study of toothpaste containing 1450 ppm sodium monofluorophosphate and xylitol (control, 15 patients) and toothpaste additionally containing extracts of the medicinal herbs (experiment, 35 patients) was performed on patients with gingivitis and the initial stage of periodontitis. Clinical indices of gingivitis/periodontitis were quantified by Loe &amp; Silness&rsquo;s, CPITN, OHI-S, and PMA indexes. The pro-inflammatory and anti-inflammatory interleukins, nitrites/nitrates, total antioxidant activity, and bacterial pattern characteristic for gingivitis and periodontitis were quantified in the gingival crevicular fluid and plaque. In the in vitro tests, direct anti-bacterial effects, inhibition of catalase induction in Staphylococcus aureus, in response to oxidative burst of phagocytes, and intracellular bacterial killing were determined for the toothpastes, individual plant extracts, and their mixture. Results: Experimental toothpaste was more efficient clinically and in the diminishing of bacterial load specific for gingivitis/periodontitis. Although the control toothpaste exerted a direct moderate anti-bacterial effect, herbal extracts provided anti-inflammatory, anti-oxidant, direct, and indirect anti-bacterial actions through inhibition of bacterial defence against phagocytes. Conclusions: Chemical and plant-derived anti-bacterials to treat gingivitis and periodontitis at the initial stage should be used in combination amid their different mechanisms of action. Plant-derived actives for oral care could substitute toxic chemicals due to multiple modes of positive effects